2005
Sterol stringency of proliferation and cell cycle progression in human cells
Suárez Y, Fernández C, Ledo B, Martín M, Gómez-Coronado D, Lasunción MA. Sterol stringency of proliferation and cell cycle progression in human cells. Biochimica Et Biophysica Acta 2005, 1734: 203-213. PMID: 15904877, DOI: 10.1016/j.bbalip.2005.02.003.Peer-Reviewed Original ResearchConceptsCell cycle progressionCycle progressionG2/M phaseMammalian cellsCell proliferationCell growthM phaseRegulator of proliferationSterol response elementCholesterol-free mediumPlasma membraneCell cycleResponse elementIsoprenoid derivativesStructural roleHuman cellsCholesterol biosynthesisSKF 104976Sterol analoguesDifferent sterolsHuman leukemiaCell processesCholesterol analoguesHL-60Concentration-dependent manner
2002
Differential effects of ergosterol and cholesterol on Cdk1 activation and SRE‐driven transcription
Suárez Y, Fernández C, Ledo B, Ferruelo AJ, Martín M, Vega MA, Gómez‐Coronado D, Lasunción MA. Differential effects of ergosterol and cholesterol on Cdk1 activation and SRE‐driven transcription. The FEBS Journal 2002, 269: 1761-1771. PMID: 11895447, DOI: 10.1046/j.1432-1327.2002.02822.x.Peer-Reviewed Original ResearchConceptsHuman cellsCdk1 activationCell cycle machineryCell membrane formationCell cycle progressionCholesterol-free mediumCell cycle arrestG2/M phaseSpecific regulatorsCycle machineryGene constructsYeast sterolCycle progressionCell cycleCell proliferation inhibitionCycle arrestAction of cholesterolUCN-01Cell growthCyclin B1 expressionSKF 104976Cholesterol homeostasisM phaseMembrane formationCell proliferation