2009
Nogo-B Receptor Stabilizes Niemann-Pick Type C2 Protein and Regulates Intracellular Cholesterol Trafficking
Harrison KD, Miao RQ, Fernandez-Hernándo C, Suárez Y, Dávalos A, Sessa WC. Nogo-B Receptor Stabilizes Niemann-Pick Type C2 Protein and Regulates Intracellular Cholesterol Trafficking. Cell Metabolism 2009, 10: 208-218. PMID: 19723497, PMCID: PMC2739452, DOI: 10.1016/j.cmet.2009.07.003.Peer-Reviewed Original ResearchConceptsNiemann-Pick type C2 (NPC2) proteinIntracellular cholesterol traffickingC2 proteinCholesterol traffickingEndoplasmic reticulumTwo-hybrid screenC-terminal domainCellular rolesIntracellular cholesterol accumulationSterol sensingProtein stabilityN-terminusNgBRProteinProtein levelsNPC2 mutationsCholesterol accumulationGenetic deficiencyTraffickingRNAiNPC2TerminusBiologyBaitReticulum
2003
Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells.
Suárez Y, González L, Cuadrado A, Berciano M, Lafarga M, Muñoz A. Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells. Molecular Cancer Therapeutics 2003, 2: 863-72. PMID: 14555705.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid Chloromethyl KetonesApoptosisBreast NeoplasmsCaspase InhibitorsCaspasesCell CycleCell NucleusCell Transformation, NeoplasticCysteine Proteinase InhibitorsDepsipeptidesFemaleFlow CytometryHumansLysosomesMaleMollusk VenomsOligopeptidesPeptidesProstatic NeoplasmsTumor Cells, CulturedConceptsAnti-apoptotic Bcl-2 proteinGeneral caspase inhibitorSevere cytoplasmic swellingMitochondrial membrane potentialCell cycle arrestBcl-2 proteinKahalalide FTranslation inhibitorsMarine-derived compoundsNuclear domainsCaspase inhibitorsNuclear envelopeNew marine-derived compoundDNA degradationEndoplasmic reticulumHuman cellsCell deathNovel antitumor drugsBreast cancer cellsJC-1LysoTracker GreenCell nucleiBreast cancer cell linesCancer cell linesMitochondrial damage