2022
Ventromedial hypothalamic OGT drives adipose tissue lipolysis and curbs obesity
Wang Q, Zhang B, Stutz B, Liu ZW, Horvath TL, Yang X. Ventromedial hypothalamic OGT drives adipose tissue lipolysis and curbs obesity. Science Advances 2022, 8: eabn8092. PMID: 36044565, PMCID: PMC9432828, DOI: 10.1126/sciadv.abn8092.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAnimalsBody WeightHypothalamusLipolysisMiceN-AcetylglucosaminyltransferasesObesityConceptsVentromedial hypothalamusWhite adipose tissueVMH neuronsAdipose tissueBody weightLipid metabolismRapid weight gainCounterregulatory responsesSympathetic activitySympathetic innervationAdipocyte hypertrophyTissue lipolysisNeuronal excitabilityFood intakePhysical activityObesity phenotypesGenetic ablationWeight gainHomeostatic set pointEnergy expenditureNeuronsInnervationLipolysisSignificant changesCellular sensors
2016
Elevated O-GlcNAcylation promotes gastric cancer cells proliferation by modulating cell cycle related proteins and ERK 1/2 signaling
Jiang M, Qiu Z, Zhang S, Fan X, Cai X, Xu B, Li X, Zhou J, Zhang X, Chu Y, Wang W, Liang J, Horvath T, Yang X, Wu K, Nie Y, Fan D. Elevated O-GlcNAcylation promotes gastric cancer cells proliferation by modulating cell cycle related proteins and ERK 1/2 signaling. Oncotarget 2016, 7: 61390-61402. PMID: 27542217, PMCID: PMC5308659, DOI: 10.18632/oncotarget.11359.Peer-Reviewed Original ResearchMeSH KeywordsAcetylglucosamineAnimalsCell CycleCell Line, TumorCell ProliferationCyclin D1Cyclin-Dependent Kinase 2Down-RegulationFemaleGene Knockdown TechniquesHumansMaleMAP Kinase Signaling SystemMiceMice, Inbred BALB CMice, NudeMiddle AgedMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3N-AcetylglucosaminyltransferasesPhosphorylationProtein Processing, Post-TranslationalRNA InterferenceRNA, Small InterferingSerineStomach NeoplasmsThreonineUp-RegulationXenograft Model Antitumor AssaysConceptsO-GlcNAcylationERK 1/2GlcNAcylation levelsCell cycleInhibition of OGTCell proliferationVivo xenograft assaysGastric cancer cell proliferationGC cell proliferationERK 1/2 pathwayERK-1/2 signalingThreonine residuesGastric cancer cell linesGlcNAc transferaseO-GlcNAcCancer cell proliferationTarget proteinsOGT levelsGastric epithelial cellsOnly enzymeXenograft assayPotential novel therapeutic targetPhosphorylation levelsCDK-2Cancer cell lines
2014
O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat
Ruan HB, Dietrich MO, Liu ZW, Zimmer MR, Li MD, Singh JP, Zhang K, Yin R, Wu J, Horvath TL, Yang X. O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat. Cell 2014, 159: 306-317. PMID: 25303527, PMCID: PMC4509746, DOI: 10.1016/j.cell.2014.09.010.Peer-Reviewed Original ResearchMeSH KeywordsAdipose Tissue, BrownAdipose Tissue, WhiteAgouti-Related ProteinAnimalsDietFastingFemaleGhrelinHypothalamusInsulin ResistanceMaleMice, Inbred C57BLMice, KnockoutN-AcetylglucosaminyltransferasesNeuronsObesityConceptsAgRP neuronsFundamental cellular processesWhite fatN-acetylglucosamine (O-GlcNAc) modificationOrexigenic AgRP neuronsVoltage-dependent potassium channelsCellular processesGlcNAc transferaseDynamic physiological processesNuclear proteinsWhite adipose tissue browningPhysiological processesAdipose tissue browningDiet-induced obesityPhysiological relevanceTissue browningGenetic ablationBeige cellsEnergy metabolismInsulin resistanceNeuronal excitabilityPotassium channelsAdipose tissueCentral mechanismsNeurons