2017
4.19 Obesity and Appetite: Central Control Mechanisms
Horvath T. 4.19 Obesity and Appetite: Central Control Mechanisms. 2017, 369-376. DOI: 10.1016/b978-0-12-803592-4.00085-7.Peer-Reviewed Original ResearchLate-onset chronic diseasesChronic diseasesPrevalence of obesitySerious comorbiditiesFat massTissue malignancyParkinson's diseaseCardiovascular disordersCentral control mechanismAlzheimer's diseaseDiseaseEpigenetic vulnerabilityCellular energy metabolismObesityVulnerable individualsEnergy metabolismAppetiteDisordersTissueDifferent tissuesComorbiditiesDiabetesMajor roleMalignancySatiety
2013
Mitochondrial Dynamics Controlled by Mitofusins Regulate Agrp Neuronal Activity and Diet-Induced Obesity
Dietrich MO, Liu ZW, Horvath TL. Mitochondrial Dynamics Controlled by Mitofusins Regulate Agrp Neuronal Activity and Diet-Induced Obesity. Cell 2013, 155: 188-199. PMID: 24074868, PMCID: PMC4142434, DOI: 10.1016/j.cell.2013.09.004.Peer-Reviewed Original ResearchConceptsMitochondrial dynamicsEnergy metabolismCell-type specificCellular energy metabolismWhole-body energy metabolismKey organellesMitofusin 1Mitofusin 2High-fat dietMitochondria sizeAgRP neuronsMfn1Anorexigenic pro-opiomelanocortin (POMC) neuronsAgRP neuronal activityKnockout miceMetabolismPro-opiomelanocortin (POMC) neuronsFusion mechanismDiet-Induced ObesityMitofusinsOverfed stateImportant roleCellsDynamic changesOrganelles
2012
Ghrelin Regulation of Learning, Memory, and Neurodegeneration
Horvath T. Ghrelin Regulation of Learning, Memory, and Neurodegeneration. Contemporary Endocrinology 2012, 171-180. DOI: 10.1007/978-1-61779-903-7_9.Peer-Reviewed Original ResearchLate-onset chronic diseasesChronic diseasesGut-derived hormonesCause of morbidityChronic disease developmentGhrelin regulationGhrelin actionPeripheral mechanismsBrain healthTissue malignancyCardiovascular disordersParkinson's diseaseCalorie restrictionBrain functionDiseaseProlongs longevityEpigenetic vulnerabilityFinancial burdenGhrelinCellular energy metabolismDisease developmentEnergy metabolismIntegrative physiologyTissueHealth