2024
Post-Treatment Alterations in White Matter Integrity in PTSD: Effects on Symptoms and Functional Connectivity a secondary analysis of an RCT
Korem N, Duek O, Ben-Zion Z, Spiller T, Gordon C, Amen S, Levy I, Harpaz-Rotem I. Post-Treatment Alterations in White Matter Integrity in PTSD: Effects on Symptoms and Functional Connectivity a secondary analysis of an RCT. Psychiatry Research Neuroimaging 2024, 111864. DOI: 10.1016/j.pscychresns.2024.111864.Peer-Reviewed Original ResearchReduced resting-state functional connectivityPost-traumatic stress disorderPost-traumatic stress disorder symptomsFunctional connectivityPost-treatment changesReducing PTSD symptom severityFollow-up changesResting-state functional connectivityIntensive exposure therapyExposure-based psychotherapyVentromedial prefrontal cortexPTSD symptom severityReduced structural connectivityFunctional connectivity patternsPost-treatmentWhite matter integrityPrefrontal cortexExposure therapyPTSD symptomsStress disorderSymptom severityUncinate fasciculusLimbic systemSecondary analysisAssociated with sustained changesUnpacking workplace stress and forensic expert decision-making: From theory to practice
Almazrouei M, Kukucka J, Morgan R, Levy I. Unpacking workplace stress and forensic expert decision-making: From theory to practice. Forensic Science International Synergy 2024, 8: 100473. PMID: 38737991, PMCID: PMC11087230, DOI: 10.1016/j.fsisyn.2024.100473.Peer-Reviewed Original Research41. Neurobehavioral Mapping of Posttraumatic Stress Disorder Development in Recent Trauma Survivors
Ben-Zion Z, Lee K, Fonteneau C, Liberzon I, Shalev A, Hendler T, Levy I, Anticevic A, Harpaz-Rotem I. 41. Neurobehavioral Mapping of Posttraumatic Stress Disorder Development in Recent Trauma Survivors. Biological Psychiatry 2024, 95: s92. DOI: 10.1016/j.biopsych.2024.02.219.Peer-Reviewed Original Research351. High-Threshold-Low-Tolerance: A Model for the Emotionality Paradox in PTSD
Korem N, Duek O, Spiller T, Ben-Zion Z, Levy I, Harpaz-Rotem I. 351. High-Threshold-Low-Tolerance: A Model for the Emotionality Paradox in PTSD. Biological Psychiatry 2024, 95: s243. DOI: 10.1016/j.biopsych.2024.02.850.Peer-Reviewed Original Research320. A Preliminary Investigation of Risk and Ambiguity Attitudes in Adult Patients With Bulimia Nervosa
Rich A, Levy I, Aimufua I, Konova A, Walsh B, Hagan K. 320. A Preliminary Investigation of Risk and Ambiguity Attitudes in Adult Patients With Bulimia Nervosa. Biological Psychiatry 2024, 95: s231. DOI: 10.1016/j.biopsych.2024.02.819.Peer-Reviewed Original ResearchEmotional State Transitions in Trauma-Exposed Individuals With and Without Posttraumatic Stress Disorder
Korem N, Duek O, Spiller T, Ben-Zion Z, Levy I, Harpaz-Rotem I. Emotional State Transitions in Trauma-Exposed Individuals With and Without Posttraumatic Stress Disorder. JAMA Network Open 2024, 7: e246813. PMID: 38625701, PMCID: PMC11022112, DOI: 10.1001/jamanetworkopen.2024.6813.Peer-Reviewed Original ResearchPosttraumatic stress disorderTrauma-exposed individualsEmotional numbing symptomsTrauma-exposed controlsNegative emotional statesNumbing symptomsEmotional numbingDSM-5Valence ratingsStress disorderEmotional statesTrauma-exposed control groupPTSD experiencesPosttraumatic stress disorder symptomsPosttraumatic Stress Disorder ChecklistDSM-5 criteriaAge-related associationsStimulus valencePCL-5Emotional responsesEmotional state transitionEmotional transitionSymptomsParticipantsDisordersManipulating the reliability of target-color information modulates value-driven attentional capture
Massa N, Crotty N, Levy I, Grubb M. Manipulating the reliability of target-color information modulates value-driven attentional capture. Attention, Perception, & Psychophysics 2024, 86: 1108-1119. PMID: 38538947, PMCID: PMC11093855, DOI: 10.3758/s13414-024-02878-7.Peer-Reviewed Original ResearchSmaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup
Huggins A, Baird C, Briggs M, Laskowitz S, Hussain A, Fouda S, Haswell C, Sun D, Salminen L, Jahanshad N, Thomopoulos S, Veltman D, Frijling J, Olff M, van Zuiden M, Koch S, Nawjin L, Wang L, Zhu Y, Li G, Stein D, Ipser J, Seedat S, du Plessis S, van den Heuvel L, Suarez-Jimenez B, Zhu X, Kim Y, He X, Zilcha-Mano S, Lazarov A, Neria Y, Stevens J, Ressler K, Jovanovic T, van Rooij S, Fani N, Hudson A, Mueller S, Sierk A, Manthey A, Walter H, Daniels J, Schmahl C, Herzog J, Říha P, Rektor I, Lebois L, Kaufman M, Olson E, Baker J, Rosso I, King A, Liberzon I, Angstadt M, Davenport N, Sponheim S, Disner S, Straube T, Hofmann D, Qi R, Lu G, Baugh L, Forster G, Simons R, Simons J, Magnotta V, Fercho K, Maron-Katz A, Etkin A, Cotton A, O’Leary E, Xie H, Wang X, Quidé Y, El-Hage W, Lissek S, Berg H, Bruce S, Cisler J, Ross M, Herringa R, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Tomas C, Fitzgerald J, Blackford J, Olatunji B, Kremen W, Lyons M, Franz C, Gordon E, May G, Nelson S, Abdallah C, Levy I, Harpaz-Rotem I, Krystal J, Dennis E, Tate D, Cifu D, Walker W, Wilde E, Harding I, Kerestes R, Thompson P, Morey R. Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup. Molecular Psychiatry 2024, 29: 611-623. PMID: 38195980, PMCID: PMC11153161, DOI: 10.1038/s41380-023-02352-0.Peer-Reviewed Original Research
2023
Neural patterns differentiate traumatic from sad autobiographical memories in PTSD
Perl O, Duek O, Kulkarni K, Gordon C, Krystal J, Levy I, Harpaz-Rotem I, Schiller D. Neural patterns differentiate traumatic from sad autobiographical memories in PTSD. Nature Neuroscience 2023, 26: 2226-2236. PMID: 38036701, DOI: 10.1038/s41593-023-01483-5.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderTraumatic memoriesAutobiographical memoryNeural patternsIntersubject representational similarity analysisSimilar neural representationsRepresentational similarity analysisPosterior cingulate cortexTrauma memoriesMnemonic featuresNegative memoriesMultivoxel patternsNeural representationCognitive stateHippocampal representationsCognitive entitiesStress disorderCingulate cortexNeural activityTraumatic narrativesIndividual symptom severitySemantic representationMemory typesOwn memoryMemoryExamining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods
Yang J, Huggins A, Sun D, Baird C, Haswell C, Frijling J, Olff M, van Zuiden M, Koch S, Nawijn L, Veltman D, Suarez-Jimenez B, Zhu X, Neria Y, Hudson A, Mueller S, Baker J, Lebois L, Kaufman M, Qi R, Lu G, Říha P, Rektor I, Dennis E, Ching C, Thomopoulos S, Salminen L, Jahanshad N, Thompson P, Stein D, Koopowitz S, Ipser J, Seedat S, du Plessis S, van den Heuvel L, Wang L, Zhu Y, Li G, Sierk A, Manthey A, Walter H, Daniels J, Schmahl C, Herzog J, Liberzon I, King A, Angstadt M, Davenport N, Sponheim S, Disner S, Straube T, Hofmann D, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Blackford J, Olatunji B, Gordon E, May G, Nelson S, Abdallah C, Levy I, Harpaz-Rotem I, Krystal J, Morey R, Sotiras A. Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods. Neuropsychopharmacology 2023, 49: 609-619. PMID: 38017161, PMCID: PMC10789873, DOI: 10.1038/s41386-023-01763-5.Peer-Reviewed Original ResearchPosttraumatic stress disorderStructural covariance networksCortical thicknessPTSD diagnosisInsular cortexPTSD patientsCingulate cortexSymptom severityBilateral superior frontal cortexStress disorderGreater cortical thicknessLower cortical thicknessChildhood trauma severitySuperior frontal cortexRegression analysisAnterior cingulate cortexTrauma-exposed controlsPosterior cingulate cortexPrefrontal regulatory regionsPTSD symptom severityComorbid depressionMotor cortexHealthy controlsFrontal cortexAlcohol abuseEffects of a dissociative drug on fronto-limbic resting-state functional connectivity in individuals with posttraumatic stress disorder: a randomized controlled pilot study
Danböck S, Duek O, Ben-Zion Z, Korem N, Amen S, Kelmendi B, Wilhelm F, Levy I, Harpaz-Rotem I. Effects of a dissociative drug on fronto-limbic resting-state functional connectivity in individuals with posttraumatic stress disorder: a randomized controlled pilot study. Psychopharmacology 2023, 241: 243-252. PMID: 37872291, PMCID: PMC10806226, DOI: 10.1007/s00213-023-06479-4.Peer-Reviewed Original ResearchResting-state functional connectivityPosttraumatic stress disorderFunctional magnetic resonance imagingMedial prefrontal cortexMPFC subregionsAnterior medial PFCFunctional connectivityStress disorderAspartate glutamate receptor antagonistPilot studyNon-competitive N-methylGlutamate receptor antagonistsEffects of ketamineDissociative drugsMagnetic resonance imagingIntravenous drug infusionReceptor antagonistSubanesthetic doseDrug infusionCorrelative findingsKetamineResonance imagingTransient decreaseDrug midazolamAmygdalaStructural Neuroimaging of Hippocampus and Amygdala Subregions in Posttraumatic Stress Disorder: A Scoping Review
Ben-Zion Z, Korem N, Fine N, Katz S, Siddhanta M, Funaro M, Duek O, Spiller T, Danböck S, Levy I, Harpaz-Rotem I. Structural Neuroimaging of Hippocampus and Amygdala Subregions in Posttraumatic Stress Disorder: A Scoping Review. Biological Psychiatry Global Open Science 2023, 4: 120-134. PMID: 38298789, PMCID: PMC10829655, DOI: 10.1016/j.bpsgos.2023.07.001.Peer-Reviewed Original ResearchPost-traumatic stress disorderAmygdala subregionsStress disorderKey limbic regionsEtiology of PTSDPosttraumatic stress disorderDentate gyrusLimbic regionsSubiculum volumeSubregion volumesHippocampal subregionsDisorder pathogenesisStructural neuroimagingAutomatic segmentation softwareAmygdalar subregionsHippocampusNucleus volumeScoping ReviewPathogenesisCurrent literatureDisordersSegmentation softwareMethodological limitationsPost-traumatic psychopathologyReviewLong term structural and functional neural changes following a single infusion of Ketamine in PTSD
Duek O, Korem N, Li Y, Kelmendi B, Amen S, Gordon C, Milne M, Krystal J, Levy I, Harpaz-Rotem I. Long term structural and functional neural changes following a single infusion of Ketamine in PTSD. Neuropsychopharmacology 2023, 48: 1648-1658. PMID: 37270621, PMCID: PMC10517133, DOI: 10.1038/s41386-023-01606-3.Peer-Reviewed Original ResearchConceptsKetamine recipientsSingle infusionMain study outcomeTiming of administrationEnd of treatmentNMDA receptor antagonistFunctional neural changesFrequency of administrationSignificant clinical implicationsTrauma-focused psychotherapyBrief exposure therapyAmygdala-vmPFC connectivityPost-retrieval extinctionKetamine doseKetamine administrationReceptor antagonistTrauma scriptsNeural changesClinical implicationsDecreased connectivityExposure therapyKetamineTrauma memoriesStudy outcomesUncinate fasciculusUncertainty in learning and decision-making: Introduction to the special issue
Levy I, Schiller D. Uncertainty in learning and decision-making: Introduction to the special issue. Cognitive, Affective, & Behavioral Neuroscience 2023, 23: 459-464. PMID: 37222931, DOI: 10.3758/s13415-023-01111-6.Peer-Reviewed Original ResearchNeural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach
Jia R, Ruderman L, Pietrzak R, Gordon C, Ehrlich D, Horvath M, Mirchandani S, DeFontes C, Southwick S, Krystal J, Harpaz-Rotem I, Levy I. Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach. Translational Psychiatry 2023, 13: 101. PMID: 36977676, PMCID: PMC10050320, DOI: 10.1038/s41398-023-02388-4.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderValuation systemStress disorderCombat veteransMaintenance of PTSDSubjective valueBrain valuation systemNeural valuation systemVentromedial prefrontal cortexFunctional MRI studyFunction of symptomsMale combat veteransNeural valuationSeries of choicesFear learningPunishment processingPosttrauma symptomsPTSD symptomsNeural encodingNeural mechanismsUncertain optionsPrefrontal cortexSubjective valuationVentral striatumMonetary gainsThe composition of the choice set modulates probability weighting in risky decisions
Grubb M, Li Y, Larisch R, Hartmann J, Gottlieb J, Levy I. The composition of the choice set modulates probability weighting in risky decisions. Cognitive, Affective, & Behavioral Neuroscience 2023, 23: 666-677. PMID: 36702993, DOI: 10.3758/s13415-023-01062-y.Peer-Reviewed Original ResearchEvaluating the Evidence for Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma
Ben-Zion Z, Spiller T, Keynan J, Admon R, Levy I, Liberzon I, Shalev A, Hendler T, Harpaz-Rotem I. Evaluating the Evidence for Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma. American Journal Of Psychiatry 2023, 180: 146-154. PMID: 36628514, PMCID: PMC9898083, DOI: 10.1176/appi.ajp.20220271.Peer-Reviewed Original ResearchConceptsPosttraumatic psychopathologyPsychiatric vulnerabilityGeneral hospital emergency departmentHospital emergency departmentRecent trauma survivorsAdditional replication studiesEmergency departmentObjective neural markersDifferent longitudinal patternsProspective symptomsMonths posttraumaAcute aftermathPsychiatric disordersEffective personalized treatmentTrauma exposureFunctional MRIPersonalized treatmentConsistent subgroupTreatment implicationsNeural activityAssessment 1Neural markersLongitudinal studyNeurobiological indicesDiagnostic methods
2021
Assessing consumer demand with noisy neural measurements
Webb R, Mehta N, Levy I. Assessing consumer demand with noisy neural measurements. Journal Of Econometrics 2021, 222: 89-106. DOI: 10.1016/j.jeconom.2020.07.028.Peer-Reviewed Original Research
2019
Neural Random Utility: Relating Cardinal Neural Observables to Stochastic Choice Behavior
Webb R, Levy I, Lazzaro S, Rutledge R, Glimcher P. Neural Random Utility: Relating Cardinal Neural Observables to Stochastic Choice Behavior. Journal Of Neuroscience Psychology And Economics 2019, 12: 45-72. DOI: 10.1037/npe0000101.Peer-Reviewed Original Research
2017
Distributed neural representation of saliency controlled value and category during anticipation of rewards and punishments
Zhang Z, Fanning J, Ehrlich DB, Chen W, Lee D, Levy I. Distributed neural representation of saliency controlled value and category during anticipation of rewards and punishments. Nature Communications 2017, 8: 1907. PMID: 29203854, PMCID: PMC5714958, DOI: 10.1038/s41467-017-02080-4.Peer-Reviewed Original ResearchConceptsNeural representationAnticipation of rewardDecision-related informationCognitive neuroscienceOutcome anticipationValue signalsPotential confoundsCategory informationHuman brainNeural signalsSaliencyRewardValuation taskAnticipationMultiple aspectsStrong supportActivity patternsPunishmentVmPFCRepresentationNeuroscienceConfoundsExtensive literatureEncodingTask