Research
Y-Age members and affiliated faculty study diverse aspects of the biology of aging. This endeavor spans the development and use of genetic model organisms through direct study of human disease and aging. Areas of research of Y-Age include investigation into mechanism of immunological aging, tissue resident immunity, infectious disease susceptibility in elderly, DNA damage and cellular senescence, inflammation, hypothalamic control of aging, neurodegeneration, aging & cancer, metabolic drivers of aging, and nutritional interventions that promote longevity.
Y-Age is housed primarily in the Yale Department of Pathology and its members constitute a major arm of the research mission therein. However, members and affiliated faculty also interact with other existing centers and programs at Yale in geriatric medicine and other age-related diseases. In aggregate, this represents interactions between many departments at Yale School of Medicine and Yale University, including Immunobiology, Comparative Medicine, Medicine, Physiology, Genetics, and Molecular and Cellular Biology.