2018
Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre‐implantation embryos
Wang T, Babayev E, Jiang Z, Li G, Zhang M, Esencan E, Horvath T, Seli E. Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre‐implantation embryos. Aging Cell 2018, 17: e12784. PMID: 29851234, PMCID: PMC6052477, DOI: 10.1111/acel.12784.Peer-Reviewed Original ResearchConceptsMitochondrial unfolded protein responseUnfolded mitochondrial proteinsCaseinolytic peptidase PAbsence of ClpPUnfolded protein responsePre-implantation embryosExpression of genesOocyte mitochondrial functionTwo-cell embryosProtein homeostasisMTOR inhibitor rapamycinMitochondrial proteinsOocyte competenceClpPProtein responseInhibitor rapamycinMitochondrial functionP-Akt473P-S6KOvarian follicular reserveSmall mitochondriaMTOR pathway activationPathway activationEmbryosP-S6
2003
Estrogen, synaptic plasticity and hypothalamic reproductive aging
Hung AJ, Stanbury MG, Shanabrough M, Horvath TL, Garcia-Segura LM, Naftolin F. Estrogen, synaptic plasticity and hypothalamic reproductive aging. Experimental Gerontology 2003, 38: 53-59. PMID: 12543261, DOI: 10.1016/s0531-5565(02)00183-3.Peer-Reviewed Original ResearchConceptsConstant estrusReproductive agingEstrogen exposureMale ratsAnti-oxidant vitamin EEarly estrogen exposureArcuate nucleus neuronsHypothalamic arcuate nucleus neuronsConstant vaginal estrusHypothalamic failureEstradiol exposureGonadotrophin surgeOvarian estrogenArcuate nucleusConstant diestrusNucleus neuronsOvarian failureElevated estradiolPerikaryal membraneFemale ratsPerinatal periodTesticular androgensRat brainSex steroidsHormonal factors
1998
Kainate Glutamate Receptors (GluR5–7) in the Rat Arcuate Nucleus: Relationship to Tanycytes, Astrocytes, Neurons and Gonadal Steroid Receptors
Diano S, Naftolin F, Horvath T. Kainate Glutamate Receptors (GluR5–7) in the Rat Arcuate Nucleus: Relationship to Tanycytes, Astrocytes, Neurons and Gonadal Steroid Receptors. Journal Of Neuroendocrinology 1998, 10: 239-247. PMID: 9630393, DOI: 10.1046/j.1365-2826.1998.00195.x.Peer-Reviewed Original ResearchConceptsGonadal steroid receptorsKainate glutamate receptorsArcuate nucleusGlutamate receptorsKainate receptorsSteroid receptorsGlutamate actionAndrogen receptorGlial elementsMorphological synaptic plasticityNeuro-glial interactionsRat arcuate nucleusIonotropic glutamate receptorsElectron microscopic immunocytochemistrySame perikaryaGonadal steroidsExcitatory neurotransmissionSynaptic plasticityMicroscopic immunocytochemistryReceptorsNeuronsCell populationsDouble labelHormone regulationAstrocytes