2021
Testing the effects of the GLP-1 receptor agonist exenatide on cocaine self-administration and subjective responses in humans with cocaine use disorder
Angarita GA, Matuskey D, Pittman B, Costeines JL, Potenza MN, Jastreboff AM, Schmidt HD, Malison RT. Testing the effects of the GLP-1 receptor agonist exenatide on cocaine self-administration and subjective responses in humans with cocaine use disorder. Drug And Alcohol Dependence 2021, 221: 108614. PMID: 33621809, PMCID: PMC8026565, DOI: 10.1016/j.drugalcdep.2021.108614.Peer-Reviewed Original ResearchConceptsCocaine use disorderGLP-1Use disordersGLP-1 receptor agonist exenatideGlucagon-like peptide-1 analogSubjective effectsEfficacy of exenatideLevels of amylinPreclinical rodent studiesPeptide-1 analogVisual analog scaleGLP-1 analoguesSelf-reported euphoriaInfusion of cocaineSelf-administer cocaineAcute pretreatmentSecondary outcomesPrimary outcomeAnalog scaleHormone levelsRodent studiesExenatidePlaceboCocaine infusionsCUD subjects
2017
Stress, cortisol, and other appetite‐related hormones: Prospective prediction of 6‐month changes in food cravings and weight
Chao AM, Jastreboff AM, White MA, Grilo CM, Sinha R. Stress, cortisol, and other appetite‐related hormones: Prospective prediction of 6‐month changes in food cravings and weight. Obesity 2017, 25: 713-720. PMID: 28349668, PMCID: PMC5373497, DOI: 10.1002/oby.21790.Peer-Reviewed Original ResearchConceptsFuture weight gainAppetite-related hormonesFood cravingsChronic stressWeight gainProspective community cohortFood Craving InventoryTotal ghrelinCommunity cohortBlood drawMorning cortisolClinical covariatesHormone levelsBody weightCortisol responseHigher food cravingsHigher cortisolCortisolCumulative Adversity InterviewCravingLinear mixed modelsBaselineGhrelinHormoneMonths