2024
Tirzepatide for Obesity Treatment and Diabetes Prevention
Jastreboff A, le Roux C, Stefanski A, Aronne L, Halpern B, Wharton S, Wilding J, Perreault L, Zhang S, Battula R, Bunck M, Ahmad N, Jouravskaya I. Tirzepatide for Obesity Treatment and Diabetes Prevention. New England Journal Of Medicine 2024 PMID: 39536238, DOI: 10.1056/nejmoa2410819.Peer-Reviewed Original ResearchType 2 diabetesProgression to type 2 diabetesDose escalation periodRisk of progression to type 2 diabetesBody weightDoses of tirzepatideBaseline to weekOnce-weekly dosingOff-treatment periodSustained weight reductionYear of treatmentDiagnosis of type 2 diabetesAssigned doseDouble-blindPlacebo groupAdverse eventsTirzepatideTirzepatide groupsPlaceboCausal precursorsSafety signalsObesity treatmentSustained reductionDelay progression to type 2 diabetesObesityEffect of Semaglutide on Regression and Progression of Glycemia in People With Overweight or Obesity but Without Diabetes in the SELECT Trial
Kahn S, Deanfield J, Jeppesen O, Emerson S, Boesgaard T, Colhoun H, Kushner R, Lingvay I, Burguera B, Gajos G, Horn D, Hramiak I, Jastreboff A, Kokkinos A, Maeng M, Matos A, Tinahones F, Lincoff A, Ryan D, Investigators S. Effect of Semaglutide on Regression and Progression of Glycemia in People With Overweight or Obesity but Without Diabetes in the SELECT Trial. Diabetes Care 2024, 47: 1350-1359. PMID: 38907683, PMCID: PMC11282386, DOI: 10.2337/dc24-0491.Peer-Reviewed Original ResearchCardiovascular diseaseMagnitude of weight reductionDouble-blind trialEffect of semaglutideCases of diabetesSubcutaneous semaglutideTreatment armsFollow-upSemaglutideDiabetesHbA1cObesityIntervention exposureGlycemiaPlaceboWeeksBody weightGlycemic outcomesDiseaseWeight reductionNormoglycemiaTrialsParticipantsProgressionKg/m2
2023
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
Jastreboff A, Kaplan L, Frías J, Wu Q, Du Y, Gurbuz S, Coskun T, Haupt A, Milicevic Z, Hartman M. Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. New England Journal Of Medicine 2023, 389: 514-526. PMID: 37366315, DOI: 10.1056/nejmoa2301972.Peer-Reviewed Original ResearchConceptsBody weightPercentage changePlacebo groupEnd pointGlucagon-like peptide-1Glucose-dependent insulinotropic polypeptideLower starting doseWeight-related conditionsCommon adverse eventsPlacebo-controlled trialPrimary end pointSecondary end pointsBody mass indexTreatment of obesityDose-dependent increaseDose-response relationshipWeight reductionStarting doseAdverse eventsInsulinotropic polypeptideHeart ratePeptide-1Side effectsGlucagon receptorWeeksTirzepatide reduces body weight across body mass index (BMI) categories: A SURMOUNT-1 pre-specified analysis
Aronne L, Jastreboff A, Le Roux C, Malik R, Ahmad N, Liu B, Bunck M, Zhang S, Stefanski A, Lautenbach A. Tirzepatide reduces body weight across body mass index (BMI) categories: A SURMOUNT-1 pre-specified analysis. Diabetologie Und Stoffwechsel 2023, 18: s42-s43. DOI: 10.1055/s-0043-1767938.Peer-Reviewed Original Research
2022
Tirzepatide Once Weekly for the Treatment of Obesity
Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, Kiyosue A, Zhang S, Liu B, Bunck MC, Stefanski A. Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal Of Medicine 2022, 387: 205-216. PMID: 35658024, DOI: 10.1056/nejmoa2206038.Peer-Reviewed Original ResearchConceptsBody weightTreatment discontinuationAdverse eventsGlucagon-like peptide-1 receptor agonistsPeptide-1 receptor agonistsGlucose-dependent insulinotropic polypeptidePercentage changeDose escalation periodWeight-related complicationsCommon adverse eventsCoprimary end pointsBody mass indexSubstantial global morbidityTreatment of obesityMean percentage changePercentage of participantsMean body weightWeight reductionCardiometabolic measuresTreat populationPlacebo groupWeek 72Mean BMIWeekly dosesDose escalation
2017
Stress, cortisol, and other appetite‐related hormones: Prospective prediction of 6‐month changes in food cravings and weight
Chao AM, Jastreboff AM, White MA, Grilo CM, Sinha R. Stress, cortisol, and other appetite‐related hormones: Prospective prediction of 6‐month changes in food cravings and weight. Obesity 2017, 25: 713-720. PMID: 28349668, PMCID: PMC5373497, DOI: 10.1002/oby.21790.Peer-Reviewed Original ResearchConceptsFuture weight gainAppetite-related hormonesFood cravingsChronic stressWeight gainProspective community cohortFood Craving InventoryTotal ghrelinCommunity cohortBlood drawMorning cortisolClinical covariatesHormone levelsBody weightCortisol responseHigher food cravingsHigher cortisolCortisolCumulative Adversity InterviewCravingLinear mixed modelsBaselineGhrelinHormoneMonths