Young-Ri Shim
Postdoctoral AssociateAbout
Research
Publications
2024
A non-catalytic role of IPMK is required for PLCγ1 activation in T cell receptor signaling by stabilizing the PLCγ1-Sam68 complex.
Hong S, Kim K, Shim YR, Park J, Choi SE, Min H, Lee S, Song JJ, Kang SJ, Jeong WI, Seong RH, Kim S. A non-catalytic role of IPMK is required for PLCγ1 activation in T cell receptor signaling by stabilizing the PLCγ1-Sam68 complex. Cell Commun Signal 2024, 22: 526. PMID: 39478550, DOI: 10.1186/s12964-024-01907-0.Peer-Reviewed Original ResearchCX 3 CR1 + macrophages interact with HSCs to promote HCC through CD8 + T-cell suppression.
Jeong JM, Choi SE, Shim YR, Kim HH, Lee YS, Yang K, Kim K, Kim MJ, Chung KPS, Kim SH, Byun JS, Eun HS, Jeong WI. CX 3 CR1 + macrophages interact with HSCs to promote HCC through CD8 + T-cell suppression. Hepatology 2024 PMID: 39028913, DOI: 10.1097/HEP.0000000000001021.Peer-Reviewed Original Research
2023
xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity.
Kim HH, Shim YR, Kim HN, Yang K, Ryu T, Kim K, Choi SE, Kim MJ, Woo C, Chung KPS, Hong SH, Shin H, Suh JM, Jung Y, Hwang GS, Kim W, Kim SH, Eun HS, Seong JK, Jeong WI. xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity. Cell Rep 2023, 42: 112636. PMID: 37310859, DOI: 10.1016/j.celrep.2023.112636.Peer-Reviewed Original ResearchComprehensive transcriptomic analysis and meta-analysis identify therapeutic effects of N-acetylcysteine in nonalcoholic fatty liver disease.
Yang K, Kim HH, Shim YR, Ryu T, Kim CW. Comprehensive transcriptomic analysis and meta-analysis identify therapeutic effects of N-acetylcysteine in nonalcoholic fatty liver disease. Front Pharmacol 2023, 14: 1186582. PMID: 37256235, DOI: 10.3389/fphar.2023.1186582.Peer-Reviewed Original ResearchExosome-Based Delivery of Super-Repressor IκBα Alleviates Alcohol-Associated Liver Injury in Mice.
Kim HH, Shim YR, Choi SE, Falana TE, Yoo JK, Ahn SH, Park M, Seo H, Choi C, Jeong WI. Exosome-Based Delivery of Super-Repressor IκBα Alleviates Alcohol-Associated Liver Injury in Mice. Pharmaceutics 2023, 15 PMID: 36839957, DOI: 10.3390/pharmaceutics15020636.Peer-Reviewed Original ResearchThe Efficacy of Panax ginseng for the Treatment of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Preclinical Studies.
Yang K, Kim HH, Shim YR, Song MJ. The Efficacy of Panax ginseng for the Treatment of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Preclinical Studies. Nutrients 2023, 15 PMID: 36771427, DOI: 10.3390/nu15030721.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCatecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease.
Kim HH, Shim YR, Choi SE, Kim MH, Lee G, You HJ, Choi WM, Yang K, Ryu T, Kim K, Kim MJ, Woo C, Chung KPS, Hong SH, Eun HS, Kim SH, Ko G, Park JE, Gao B, Kim W, Jeong WI. Catecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease. Exp Mol Med 2023, 55: 158-170. PMID: 36631664, DOI: 10.1038/s12276-022-00921-x.Peer-Reviewed Original Research
2021
Metabotropic Glutamate Receptor 5 in Natural Killer Cells Attenuates Liver Fibrosis by Exerting Cytotoxicity to Activated Stellate Cells.
Choi WM, Ryu T, Lee JH, Shim YR, Kim MH, Kim HH, Kim YE, Yang K, Kim K, Choi SE, Kim W, Kim SH, Eun HS, Jeong WI. Metabotropic Glutamate Receptor 5 in Natural Killer Cells Attenuates Liver Fibrosis by Exerting Cytotoxicity to Activated Stellate Cells. Hepatology 2021, 74: 2170-2185. PMID: 33932306, DOI: 10.1002/hep.31875.Peer-Reviewed Original Research
2020
Ginsenoside F2 attenuates chronic-binge ethanol-induced liver injury by increasing regulatory T cells and decreasing Th17 cells.
Kim MH, Kim HH, Jeong JM, Shim YR, Lee JH, Kim YE, Ryu T, Yang K, Kim KR, Jeon BM, Kim SC, Jung JK, Choi JK, Lee YS, Byun JS, Jeong WI. Ginsenoside F2 attenuates chronic-binge ethanol-induced liver injury by increasing regulatory T cells and decreasing Th17 cells. J Ginseng Res 2020, 44: 815-822. PMID: 33192125, DOI: 10.1016/j.jgr.2020.03.002.Peer-Reviewed Original ResearchMitochondrial Double-Stranded RNA in Exosome Promotes Interleukin-17 Production Through Toll-Like Receptor 3 in Alcohol-associated Liver Injury.
Lee JH, Shim YR, Seo W, Kim MH, Choi WM, Kim HH, Kim YE, Yang K, Ryu T, Jeong JM, Choi HG, Eun HS, Kim SH, Mun H, Yoon JH, Jeong WI. Mitochondrial Double-Stranded RNA in Exosome Promotes Interleukin-17 Production Through Toll-Like Receptor 3 in Alcohol-associated Liver Injury. Hepatology 2020, 72: 609-625. PMID: 31849082, DOI: 10.1002/hep.31041.Peer-Reviewed Original Research