2024
Demographic diversity in platelet function and response to antiplatelet therapy
Jain K, Tyagi T, Gu S, Faustino E, Hwa J. Demographic diversity in platelet function and response to antiplatelet therapy. Trends In Pharmacological Sciences 2024 PMID: 39672782, DOI: 10.1016/j.tips.2024.11.005.Peer-Reviewed Original ResearchResponse to antiplatelet therapyCardiovascular diseaseAntiplatelet therapyPlatelet biologyPathological platelet activationCardiovascular disease riskNon-genetic factorsPopulation-based differencesAntiplatelet strategiesPlatelet functionCardiovascular outcomesDiverse rolesPlatelet activationTherapeutic approachesTherapyPlateletBiologyProtocol for the Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Studies.
Faustino E, Kandil S, Leroue M, Sochet A, Kong M, Cholette J, Nellis M, Pinto M, Chegondi M, Ramirez M, Schreiber H, Kerris E, Glau C, Kolmar A, Muisyo T, Sharathkumar A, Polikoff L, Silva C, Ehrlich L, Navarro O, Spinella P, Raffini L, Taylor S, McPartland T, Shabanova V. Protocol for the Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Studies. Pediatric Critical Care Medicine 2024 PMID: 39560771, DOI: 10.1097/pcc.0000000000003648.Peer-Reviewed Original ResearchRandomized clinical trialsDose of enoxaparinCatheter-relatedEarly thromboprophylaxisHigher risk of clinically relevant bleedingRisk of clinically relevant bleedingProphylactic doses of enoxaparinTherapeutic dose of enoxaparinOlder childrenMarkers of thrombin generationClinically relevant bleedingEfficacy of prophylaxisDeep venous thrombosisRemoval of CVCsCritically ill childrenPlatelet-poor plasmaPost hoc analysisGestational ageInternational unitsInstitutional review boardRelevant bleedingProphylactic doseUsual careAge-dependent heterogeneityVenous thrombosisAnticoagulation Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis
Azzam M, Kawtharany H, Monagle P, Bercovitz R, Hamarsha Q, Alkhader A, Abou Zeid H, Mansour R, Patel P, Tabak C, Baghdadi S, Betensky M, Bhat R, Biss T, Branchford B, Brandao L, Chan A, Faustino E, Jaffray J, Jones S, Kerlin B, Kucine N, Kumar R, Male C, Pelland-Marcotte M, Raffini L, Raulji C, Sartain S, Takemoto C, Tarango C, Van Ommen H, Velez-Yanguas M, Vesely S, Wiernikowski J, Williams S, Wilson H, Woods G, Zia A, Mustafa R. Anticoagulation Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis. Blood 2024, 144: 1257-1257. DOI: 10.1182/blood-2024-212150.Peer-Reviewed Original ResearchRisk of biasCertainty of evidenceVenous thromboembolismPediatric patientsThrombus resolutionAll-cause mortalityThrombus recurrenceAC therapyAnticoagulant therapyAbsolute effectEvents of all-cause mortalityPediatric populationSystematic reviewNon-randomized Studies of InterventionsManagement of venous thromboembolismMeta-analysisStudies of interventionsConcerns related to riskNon-randomized observational studyNon-randomized studiesRecommendations AssessmentThrombus progressionBleeding eventsBleeding riskPortal hypertensionThrombolytic Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis
Kawtharany H, Azzam M, Monagle P, Bercovitz R, Alkhader A, Hamarsha Q, Zeid H, Mansour R, Tabak C, Patel P, Baghdadi S, Betensky M, Bhat R, Biss T, Branchford B, Brandao L, Chan A, Faustino E, Jaffray J, Jones S, Kerlin B, Kucine N, Kumar R, Male C, Pelland-Marcotte M, Raffini L, Raulji C, Sartain S, Takemoto C, Tarango C, Van Ommen H, Velez M, Vesely S, Wiernikowski J, Williams S, Wilson H, Woods G, Zia A, Mustafa R. Thrombolytic Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis. Blood 2024, 144: 2633. DOI: 10.1182/blood-2024-212166.Peer-Reviewed Original ResearchRate of thrombus resolutionAbsolute riskRisk of biasCertainty of evidenceMassive PEThrombolytic therapyPediatric patientsOutcome of thrombolysisAC groupPulmonary embolismSystematic reviewThrombus resolutionCovidence systematic review softwareRisk of thrombosis recurrenceThrombolysis groupMeta-analysisConcerns related to riskSystematic review softwareSubmassive pulmonary embolismChronic pulmonary hypertensionManagement of VTERestoring venous patencyRisk of progressionCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsHigh-Dimensional Single-Cell Mass Cytometry Demonstrates Differential Platelet Functional Phenotypes in Infants With Congenital Heart Disease
Gu S, Marcus B, Gu V, Varghese A, Hwa J, Faustino E. High-Dimensional Single-Cell Mass Cytometry Demonstrates Differential Platelet Functional Phenotypes in Infants With Congenital Heart Disease. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: 2530-2539. PMID: 39171400, PMCID: PMC11602369, DOI: 10.1161/atvbaha.124.321131.Peer-Reviewed Original ResearchCongenital heart diseaseNon-CHD controlsSubpopulation of plateletsCytokine analysisAssociated with congenital heart diseaseSurface markersPlatelet activationHeart diseaseAssociated with hematological abnormalitiesChildren's Heart CenterPlasma cytokine analysisComplex heart defectsBlood of infantsThrombotic vascular complicationsIL (interleukin)-6Cell surface markersDecreased platelet activationMass cytometry approachPlatelet surface markersHypogranular plateletsHeart defectsBleeding eventsPlasma cytokinesPlatelet function phenotypesInflammatory markersBiomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock
Atreya M, Bennett T, Geva A, Faustino E, Rogerson C, Lutfi R, Cvijanovich N, Bigham M, Nowak J, Schwarz A, Baines T, Haileselassie B, Thomas N, Luo Y, Sanchez-Pinto L, Investigators F. Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock. Pediatric Critical Care Medicine 2024, 25: 512-517. PMID: 38465952, PMCID: PMC11153020, DOI: 10.1097/pcc.0000000000003499.Peer-Reviewed Original ResearchElectronic health recordsMultiple organ dysfunction syndromePediatric septic shock patientsSeptic shock patientsRisk strataElectronic health record dataSepsis phenotypesShock patientsPersistent multiple organ dysfunction syndromeAssociated with poor clinical outcomesDegree of systemic inflammationIncreased adjusted oddsHigh riskOrgan dysfunction syndromePoor clinical outcomesHealth recordsReceiver operating characteristic curveHigh-risk stratumArea under the receiver operating characteristic curveCritically ill patientsPredictive of deathSeverity of illnessAdjusted oddsIdentification of childrenOperating characteristics curveConsiderations for instituting pediatric pulmonary embolism response teams: A tool kit
Rajpurkar M, Rosovsky R, Williams S, Chan A, van Ommen C, Faustino E, White M, Parikh M, Sirachainan N, Biss T, Goldenberg N. Considerations for instituting pediatric pulmonary embolism response teams: A tool kit. Thrombosis Research 2024, 236: 97-107. PMID: 38417301, DOI: 10.1016/j.thromres.2024.02.019.Peer-Reviewed Original ResearchPulmonary Embolism Response TeamPediatric pulmonary embolismPediatric PETime to diagnosisIndividual physician's experiencePulmonary embolismDefinitive managementPE patientsResponse teamCritical care pathwayEpidemiological featuresCare pathwaysPhysician experiencePractice guidelinesPE outcomesDiagnosisCritical pathwaysPlatelet Mitochondrial Fusion and Function in Vascular Integrity
Tyagi T, Yarovinsky T, Faustino E, Hwa J. Platelet Mitochondrial Fusion and Function in Vascular Integrity. Circulation Research 2024, 134: 162-164. PMID: 38236952, PMCID: PMC10798220, DOI: 10.1161/circresaha.123.323867.Peer-Reviewed Original Research
2023
778: USE OF PERIPHERALLY INSERTED CENTRAL CATHETERS IN INFANTS: PICC STUDY
Chegondi M, Ness-Cochinwala M, Pinto M, Schreiber H, Polikoff L, Kerris E, Kothari H, Bloxham J, Berman-Sieger A, Mancuso B, Harder T, Korn S, Gillette C, Taillie E, Cholette J, Johnson R, Kaipa S, Faustino E. 778: USE OF PERIPHERALLY INSERTED CENTRAL CATHETERS IN INFANTS: PICC STUDY. Critical Care Medicine 2023, 52: s361-s361. DOI: 10.1097/01.ccm.0001001280.97724.e1.Peer-Reviewed Original Research813: BLOOD PRODUCT UTILIZATION IN INFANTS WITH PERIPHERALLY INSERTED CENTRAL CATHETERS
Ness-Cochinwala M, Chegondi M, Mancuso B, Berman-Sieger A, Pinto M, Schreiber H, Polikoff L, Kaipa S, Kerris E, Kothari H, Bloxham J, Harder T, Korn S, Gillette C, Taillie E, Cholette J, Johnson R, Faustino E. 813: BLOOD PRODUCT UTILIZATION IN INFANTS WITH PERIPHERALLY INSERTED CENTRAL CATHETERS. Critical Care Medicine 2023, 52: s379-s379. DOI: 10.1097/01.ccm.0001001420.46206.99.Peer-Reviewed Original ResearchMulticenter Study of a Risk Prediction Model for Critically Ill Children at High-Risk for Hospital-Acquired Venous Thromboembolism: Findings from the Children's Hospital-Acquired Thrombosis (CHAT) Consortium
Jaffray J, Mosha M, Branchford B, Amankwah E, Faustino E, Krava E, Stillings A, Young G, Goldenberg N. Multicenter Study of a Risk Prediction Model for Critically Ill Children at High-Risk for Hospital-Acquired Venous Thromboembolism: Findings from the Children's Hospital-Acquired Thrombosis (CHAT) Consortium. Blood 2023, 142: 809. DOI: 10.1182/blood-2023-187395.Peer-Reviewed Original ResearchHospital-acquired venous thromboembolismPediatric intensive care unitCongenital heart diseaseIll childrenMultivariable logistic regression modelAdmission/transferAutoimmune/inflammatory disordersCentral venous cathetersLength of hospitalizationCentral venous catheterizationDays post dischargeIntensive care unitUnivariate logistic regressionSubset of childrenP-valueLogistic regression modelsRisk assessment modelPICU admissionThromboprophylaxis measuresVenous thromboembolismChart reviewProspective cohortVenous cathetersCardiac surgeryMedian ageInflammation Sub-Group Analysis in Pediatric HA-VTE Cases: A Report from the Children's Hospital Acquired Thrombosis Registry (CHAT) Registry
Harp T, Proctor K, Mosha M, Cox A, Jaffray J, Stillings A, Krava E, Amankwah E, Faustino E, Zakai N, Young G, Goldenberg N, Branchford B. Inflammation Sub-Group Analysis in Pediatric HA-VTE Cases: A Report from the Children's Hospital Acquired Thrombosis Registry (CHAT) Registry. Blood 2023, 142: 4015. DOI: 10.1182/blood-2023-190491.Peer-Reviewed Original ResearchPast medical historyInflammatory disease diagnosisHA-VTEDischarge diagnosisSystemic inflammationChronic inflammationAcute inflammationInflammatory diseasesOdds ratioCentral venous catheter placementAdmission/transferDays of dischargeLong-term morbidityVenous catheter placementOrgan system involvementPediatric patient populationType of inflammationClinical research effortsSub-group analysisUnderlying risk factorsInstitutional review boardElectronic health recordsChronic varietyHospital stayVenous thromboembolismHospital-Acquired Venous Thromboembolism and Invasive Mechanical Ventilation: A Report From the Children’s Hospital Acquired Thrombosis Consortium
Sochet A, Jaffray J, Branchford B, Havlicek E, Mosha M, Amankwah E, Ignjatovic V, Faustino E, Goldenberg N. Hospital-Acquired Venous Thromboembolism and Invasive Mechanical Ventilation: A Report From the Children’s Hospital Acquired Thrombosis Consortium. Pediatric Critical Care Medicine 2023, 25: e82-e90. PMID: 37882641, PMCID: PMC10843146, DOI: 10.1097/pcc.0000000000003383.Peer-Reviewed Original ResearchHospital-acquired venous thromboembolismInvasive mechanical ventilationIMV durationVenous thromboembolismMechanical ventilationIll childrenDeep venous thrombosesPatient age groupsCase-control studyMultivariate logistic modelThromboprophylaxis practiceVenous thrombosesPrimary outcomeRisk stratificationThromboprophylaxis trialCatheterization dataMobility scoreAge groupsSecondary analysisDays durationThromboembolismLonger lengthAssociative statisticsChildrenDurationHospital-acquired venous thromboembolism during invasive mechanical ventilation in children: a single-center, retrospective cohort study
Havlicek E, Goldman Z, Faustino E, Ignjatovic V, Goldenberg N, Sochet A. Hospital-acquired venous thromboembolism during invasive mechanical ventilation in children: a single-center, retrospective cohort study. Journal Of Thrombosis And Haemostasis 2023, 21: 3145-3152. PMID: 37423387, DOI: 10.1016/j.jtha.2023.06.035.Peer-Reviewed Original ResearchConceptsHospital-acquired venous thromboembolismInvasive mechanical ventilationRetrospective cohort studyVenous thromboembolismMechanical ventilationEndotracheal intubationCohort studyIll childrenRisk factorsGeneral pediatric intensive care unit populationPediatric intensive care unit populationConcurrent central venous cathetersIntensive care unit populationExtremity deep venous thrombosisPediatric intensive care unitHypercoagulability risk factorsDeep venous thrombosisCentral venous cathetersIntensive care unitEligible encountersIMV durationPulmonary embolismSecondary outcomesVenous cathetersPrimary outcomeDerivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock*
Sanchez-Pinto L, Bennett T, Stroup E, Luo Y, Atreya M, Bubeck Wardenburg J, Chong G, Geva A, Faustino E, Farris R, Hall M, Rogerson C, Shah S, Weiss S, Khemani R. Derivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock*. Pediatric Critical Care Medicine 2023, 24: 795-806. PMID: 37272946, PMCID: PMC10540758, DOI: 10.1097/pcc.0000000000003292.Peer-Reviewed Original ResearchMultiple organ dysfunction syndromeSepsis-associated multiple organ dysfunction syndromePersistent hypoxemiaAdjuvant therapySepsis phenotypesSevere pediatric acute respiratory distress syndromePediatric acute respiratory distress syndromeMulticenter observational cohort studyAcute respiratory distress syndromePropensity score-matched analysisCommon adjuvant therapyHeterogeneity of sepsisOrgan dysfunction syndromeObservational cohort studyRespiratory distress syndromeHospital mortalityCohort studyDysfunction syndromeSystemic inflammationDistress syndromeOrgan dysfunctionSeptic shockClinical syndromeCommon therapyClinical relevanceTight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials
Zinter M, Markovic D, Asaro L, Nadkarni V, McQuillen P, Sinha P, Matthay M, Jeschke M, Agus M, Sapru A, Agus M, Coughlin-Wells K, Hughes K, French J, Fitzgerald M, Srinivasan V, Sisko M, Chima R, Howard K, Jones R, Thomas N, Spear D, Li S, Pinto A, Eldridge P, Newth C, Kwok J, Hassinger A, Qiao H, Bysani K, Monjure T, Faustino E, Tala J, Kandil S, Quinn T, Hirshberg E, Lilley J, Wintergerst K, Sullivan J, Lee K, Schwarz A, Flores C, Vargas-Shiraishi O, Sorce L, Marsillio L, Shukla A, Cvijanovich N, Flori H, Brumfield B, Stone C, Dahmer M, Jayachandran C, Federman M, Wong K, Vangala S, Pellegrini M, Balliu B, Gala K, Kirkpatrick T, Deshmukh T, Mareboina M, Do N, Ashtari N, Ratiu A, Nett S, Singleton M, Jarvis D, McNally M, Martini K, Pinto N, Chong G, Rodgers C, Viteri S, John R, Mulholland T, Pellicciotti G, Sapru A, McQuillen P, Zinter M, Goel S, Alkhouli M, McKenzie A, Villarreal-Chico D. Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 945-949. PMID: 36656551, PMCID: PMC10111993, DOI: 10.1164/rccm.202210-1988le.Peer-Reviewed Original Research
2022
Mechanical Ventilation and Hospital-Acquired Venous Thromboembolism Among Critically Ill Children.
Sochet A, Havlicek E, Faustino E, Goldenberg N. Mechanical Ventilation and Hospital-Acquired Venous Thromboembolism Among Critically Ill Children. Hospital Pediatrics 2022, 12: 1099-1109. PMID: 36349533, DOI: 10.1542/hpeds.2022-006697.Peer-Reviewed Original ResearchConceptsHospital-acquired venous thromboembolismDeep venous thrombosisMechanical ventilationMultivariable logistic regressionIll childrenVenous thromboembolismCohort studyVenous thrombosisRegistry-based cohort studyExtremity deep venous thrombosisLogistic regressionHA-VTE eventsInvasive mechanical ventilationRetrospective cohort studyVTE risk factorsCentral venous catheterizationYears of ageHospital dischargePulmonary embolismPrimary outcomeVenous catheterizationRisk factorsClinical trialsProspective validationSystem registryPractical considerations and consensus opinion for children’s hospital–based inpatient hemostasis and thrombosis (HAT) consultative services: Communication from the ISTH SSC Subcommittee on Pediatric/Neonatal Thrombosis and Hemostasis
Woods GM, Raffini L, Brandão LR, Jaffray J, Branchford BR, Ng CJ, Sartain SE, Pak J, Male C, Zia A, Rizzi M, Sirachainan N, Faustino E, Carpenter SL, Goldenberg NA. Practical considerations and consensus opinion for children’s hospital–based inpatient hemostasis and thrombosis (HAT) consultative services: Communication from the ISTH SSC Subcommittee on Pediatric/Neonatal Thrombosis and Hemostasis. Journal Of Thrombosis And Haemostasis 2022, 20: 2151-2158. PMID: 35748322, DOI: 10.1111/jth.15798.Peer-Reviewed Original ResearchConceptsTertiary care referral centerConsensus opinionAnticoagulation management serviceManagement of patientsNumerous therapeutic advancesDisorders of hemostasisISTH SSC SubcommitteeNeonatal thrombosisFellowship training programsInpatient managementReferral centerAdult hospitalsPediatric institutionTherapeutic advancesPediatric dataHAT patientsMedical complexityInpatient settingThrombosisHemostasisConsultative servicesPatientsTraining programCurrent practiceComplicationsIntroduction of Hydroxyurea Therapy to a Cohort of Sickle Cell Patients in Northern Haiti
Paul-Hanna M, Joseph W, Mondesir W, Faustino EVS, Canarie MF. Introduction of Hydroxyurea Therapy to a Cohort of Sickle Cell Patients in Northern Haiti. Journal Of Pediatric Hematology/Oncology 2022, 44: 351-353. PMID: 35180761, DOI: 10.1097/mph.0000000000002431.Peer-Reviewed Original ResearchConceptsSickle cell anemiaCell anemiaRate of hospitalizationSickle cell patientsHydroxyurea therapyHU therapySignificant complicationsCell patientsHigh prevalenceTherapyComplicationsStudy periodYoung adultsPrincipal outcomeHospitalizationPatientsAnemiaCohortPrevalenceHydroxyureaTreatmentNorthern HaitiMorbidityClinicHospital
2021
Pharmacologic restraint during ED mental health visits
Faustino E. Pharmacologic restraint during ED mental health visits. The Journal Of Pediatrics 2021, 236: 1-3. DOI: 10.1016/j.jpeds.2021.07.028.Peer-Reviewed Original Research