2024
Alterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder.
Mehta S, Peterson H, Ye J, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Arora J, Tokoglu F, Yip S, Hahn C, Lacadie C, Greene A, Jeon S, Constable R, Barry D, Redeker N, Yaggi H, Scheinost D, Weintraub E. Alterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder. Radiology 2024, 313: e240514. PMID: 39656127, DOI: 10.1148/radiol.240514.Peer-Reviewed Original ResearchConceptsHealthy control participantsRight medial temporal lobeOpioid use disorderFunctional brain alterationsMedial temporal lobeOpioid use disorder groupFunctional connectivityUse disorderControl participantsBrain alterationsIntrinsic resting-state functional connectivityTemporal lobeMedial prefrontal cortex volumesVoxel-wise linear regressionT1-weighted MRIResting-state functional connectivityFamily-wise error correctionPrefrontal cortex volumeResting-state functional MRIIncreased functional connectivityIntrinsic connectivity distributionFunctional MRI studiesFemale participantsRegional brain volumesAssess group differences
2023
Association of Body Mass Index and Waist Circumference With Imaging Metrics of Brain Integrity and Functional Connectivity in Children Aged 9 to 10 Years in the US, 2016-2018
Kaltenhauser S, Weber C, Lin H, Mozayan A, Malhotra A, Constable R, Acosta J, Falcone G, Taylor S, Ment L, Sheth K, Payabvash S. Association of Body Mass Index and Waist Circumference With Imaging Metrics of Brain Integrity and Functional Connectivity in Children Aged 9 to 10 Years in the US, 2016-2018. JAMA Network Open 2023, 6: e2314193. PMID: 37200030, PMCID: PMC10196880, DOI: 10.1001/jamanetworkopen.2023.14193.Peer-Reviewed Original ResearchConceptsBody mass indexHigher body mass indexWaist circumferenceBMI z-scoreCross-sectional studyBrain healthCross-sectional analysisFunctional connectivityMass indexMean ageInterval developmentCorpus callosumAssociation of BMIHigher baseline body mass indexBaseline cross-sectional analysisBaseline body mass indexBrain integrityResting-state functional connectivityLongitudinal analysisFuture treatment trialsABCD studyLower microstructural integrityCognitive Development StudyAdolescent Brain Cognitive Development (ABCD) studyCardiovascular implications
2022
Coordinated anatomical and functional variability in the human brain during adolescence
Bero J, Li Y, Kumar A, Humphries C, Nag S, Lee H, Ahn W, Hahn S, Constable R, Kim H, Lee D. Coordinated anatomical and functional variability in the human brain during adolescence. Human Brain Mapping 2022, 44: 1767-1778. PMID: 36479851, PMCID: PMC9921246, DOI: 10.1002/hbm.26173.Peer-Reviewed Original ResearchConceptsCortical thicknessCortical areasFunctional connectivityResting-state functional connectivityAssociation cortical areasMultiple cortical areasCortical information processingAge-related changesCortical myelinationAdult brainCytoarchitectural featuresBrain developmentInformation processingBrainDevelopmental changesHuman brainAdolescenceMyelinationPatterns of coordinationMeasuresRegional variationMyelin
2017
Connectome-based Models Predict Separable Components of Attention in Novel Individuals
Rosenberg MD, Hsu WT, Scheinost D, Constable R, Chun MM. Connectome-based Models Predict Separable Components of Attention in Novel Individuals. Journal Of Cognitive Neuroscience 2017, 30: 160-173. PMID: 29040013, DOI: 10.1162/jocn_a_01197.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingAttention Network TaskExecutive controlIntrinsic functional organizationRT variabilityANT performanceInfluential modelFunctional connectivityBrain's intrinsic functional organizationComponents of attentionExecutive control scoresResting-state functional connectivityResting-state dataFunctional brain networksFunctional organizationTask-based dataAttentional abilitiesUpcoming stimulusExplicit taskSustained attentionFMRI scanningAttention factorNovel individualsAdditional independent componentNetwork tasks