2024
EPCO-35. GENOMIC CHARACTERIZATION OF GROWTH HORMONE SECRETING PITUITARY ADENOMAS
Alanya H, Yalcin K, Hilton B, Gultekin B, Mishra-Gorur K, McGuone D, Gunel M, Omay S, Erson-Omay Z. EPCO-35. GENOMIC CHARACTERIZATION OF GROWTH HORMONE SECRETING PITUITARY ADENOMAS. Neuro-Oncology 2024, 26: viii9-viii9. PMCID: PMC11553213, DOI: 10.1093/neuonc/noae165.0034.Peer-Reviewed Original ResearchGH-secreting pituitary adenomasWhole-exome sequencingPituitary adenomasGNAS mutationsCopy number variationsSporadic GH-secreting pituitary adenomasGrowth hormone (GH)-secreting pituitary adenomasGenomic profilingGrowth hormone secreting pituitary adenomaSecreting pituitary adenomasBlood samplesComprehensive genomic characterizationSomatic GNAS mutationsSingle nucleotide variantsMatched blood samplesGenomic instabilityAssessment of genomic instabilityStatistically significant differenceTumor sizeClinical featuresTumor samplesClinical dataTumorExome sequencingBrain tumors
2017
Reoperation for growth hormone-secreting pituitary adenomas: report on an endonasal endoscopic series with a systematic review and meta-analysis of the literature.
Almeida JP, Ruiz-Treviño AS, Liang B, Omay SB, Shetty SR, Chen YN, Anand VK, Grover K, Christos P, Schwartz TH. Reoperation for growth hormone-secreting pituitary adenomas: report on an endonasal endoscopic series with a systematic review and meta-analysis of the literature. Journal Of Neurosurgery 2017, 129: 404-416. PMID: 28862548, DOI: 10.3171/2017.2.jns162673.Peer-Reviewed Original ResearchConceptsExtended endonasal endoscopic approachFirst-time surgeryCavernous sinus invasionPreoperative GH levelsSinus invasionSurgery groupControl rateDisease controlSystematic reviewReoperation groupTumor sizeGH levelsGrowth hormone-secreting pituitary adenomaHormone-secreting pituitary adenomasTransient diabetes insipidusDisease control rateFirst-line therapyResults of reoperationTime of surgerySmaller tumor sizeNegative prognostic indicatorSimilar control ratesLow control rateEndonasal endoscopic approachFirst-time operations