Mihir Gupta, MD
Assistant ProfessorCards
About
Research
Publications
2026
Diagnostic Pathways and Procedural Risk in Primary Central Nervous System Lymphoma: A Nationwide Analysis.
Qureshi K, Arakali S, Anzueto J, Huddleston D, Hobbs J, Saenz S, Thakkar R, Jayaram R, Goulart C, Alok K, Gupta M. Diagnostic Pathways and Procedural Risk in Primary Central Nervous System Lymphoma: A Nationwide Analysis. Acta Haematologica 2026, 1-11. PMID: 42081433, DOI: 10.1159/000552333.Peer-Reviewed Original ResearchPrimary central nervous system lymphomaCentral nervous system lymphomaNervous system lymphomaLumbar punctureBiopsy-onlyNeurosurgical biopsySystem lymphomaAdverse eventsPCNSL diagnosisDiagnosis of primary central nervous system lymphomaDiagnostic pathwayPrimary central nervous system lymphoma patientsPredictors of adverse eventsPost-procedural complicationsHigh-risk subgroupsMariner Claims DatabaseComplication rateThromboembolic eventsThromboembolic complicationsDiagnostic modalitiesProcedural complicationsAggressive malignancyClinical characteristicsBiopsy pathwayProcedural riskIt’s Not “Personal”: Health Information Disclosure and the Physical- Mental Distinction
Covo Y, Klug T, Olgun M, Ahmed Ramy M, Darji R, Gupta M. It’s Not “Personal”: Health Information Disclosure and the Physical- Mental Distinction. The Columbia Journal Of Law & The Arts 2026, 49: 495-548. DOI: 10.52214/jla.v49i3.14724.Peer-Reviewed Original ResearchMental health issuesAthlete's autonomyMental health reportsHealth issuesAthlete healthDisability lawPrivacy lawsHealth information disclosureRegulatory frameworkNormative sideNormative groundsIntegrity of sportPhysical injuryPersonal reasonsLawMental healthHealth reportsHealth statusInformation disclosureProfessional athletesMedical researchAthletesHealthAutonomyLeague
2025
Multi-Institutional Assessment of Circulating Cell-Free DNA in Cerebrospinal Fluid Facilitates Central Nervous System Lymphoma Diagnosis and Treatment Initiation
Prager B, Gupta M, West T, Ramundo C, Bagin J, de Macedo Filho L, Georgantas N, Pilacky R, Forst D, Jordan J, Mansouri A, Carter B, Cahill D, Nahed B, Dietrich J, Wang C, Shankar G. Multi-Institutional Assessment of Circulating Cell-Free DNA in Cerebrospinal Fluid Facilitates Central Nervous System Lymphoma Diagnosis and Treatment Initiation. Neurosurgery 2025, 99: 40-49. PMID: 41190874, DOI: 10.1227/neu.0000000000003835.Peer-Reviewed Original ResearchDiagnosis of CNS lymphomaCentral nervous system lymphomaCell-free DNACentral nervous systemMYD88 L265PTissue biopsiesPolymerase chain reactionCNS lymphomaRisk of neurological morbidityCentral nervous system biopsyDiagnosis of central nervous systemTime to treatmentCerebrospinal fluid analysisMulti-institutional assessmentTissue confirmationLymphoma diagnosisClinical responseClinical courseNeurological morbidityDiagnostic yieldTreatment initiationProspective cohortLiquid biopsyLymphomaBiopsyUnderstanding the Comorbidities Among Psychiatric Disorders, Chronic Low Back Pain, and Spinal Degenerative Disease Using Observational and Genetically Informed Analyses
Qiu D, Friligkou E, He J, Cabrera-Mendoza B, Aslan M, Gupta M, Polimanti R. Understanding the Comorbidities Among Psychiatric Disorders, Chronic Low Back Pain, and Spinal Degenerative Disease Using Observational and Genetically Informed Analyses. Biological Psychiatry Global Open Science 2025, 5: 100588. PMID: 41036474, PMCID: PMC12483661, DOI: 10.1016/j.bpsgos.2025.100588.Peer-Reviewed Original ResearchChronic low back painSpinal degenerative diseaseLow back painPolygenic risk scoresMendelian randomizationBack painOne-sample Mendelian randomizationOne-sample MRRisk scoreUs Research ProgramPsychiatric disordersMultinominal regression modelGenetically informed analysesHealth outcomesMental illnessAlcohol use disorderPosttraumatic stress disorderDegenerative diseasesSociocultural factorsControl participantsRegression modelsUse disorderAssociated with differencesComorbidity patternsStress disorderSurgical Outcomes in Patients with Primary or Metastatic Spinal Leiomyosarcoma: A Systematic Review and Meta-Analysis
Serrato P, Gupta M, Hawkins D, Sathyamangalam Samiappan S, Saha P, Lubelski D, Lee S. Surgical Outcomes in Patients with Primary or Metastatic Spinal Leiomyosarcoma: A Systematic Review and Meta-Analysis. World Neurosurgery 2025, 199: 124067. PMID: 40368091, DOI: 10.1016/j.wneu.2025.124067.Peer-Reviewed Original ResearchConceptsPrimary lesionSurgical outcomesClinical featuresMedian progression-free survivalMedian overall survivalProgression-free survivalEn-bloc resectionMeta-analysisSystematic reviewMetastatic casesMetastatic lesionsSurgical resectionOverall survivalBloc resectionSpinal lesionsMale sexLumbar locationThoracic locationFollow-upMetastasisLesionsLeiomyosarcomaResectionSurvivalPatientsTargeting sickle cell pathobiology and pain with novel transdermal curcumin
Goel Y, Arellano M, Fouda R, Garcia N, Lomeli R, Kerr D, Argueta D, Gupta M, Velasco G, Prince R, Banerjee P, Jana S, Alayash A, Friedman J, Gupta K. Targeting sickle cell pathobiology and pain with novel transdermal curcumin. PNAS Nexus 2025, 4: pgaf053. PMID: 40007577, PMCID: PMC11854080, DOI: 10.1093/pnasnexus/pgaf053.Peer-Reviewed Original ResearchSickle cell diseaseRed blood cellsInflammatory consequencesGranulocyte-macrophage colony-stimulating factorGel formulationMonocyte chemoattractant protein-1Blood cellsNormal T-cellColony-stimulating factorSickle cell miceChemoattractant protein-1Consequences of sickle cell diseaseMast cell degranulationPain hypersensitivityChronic administrationChronic painT cellsCost-effective therapeuticsCell miceProinflammatory cytokinesChronic inflammationInterleukin-6Red blood cell stabilityOral administrationCell diseaseSomatic SMARCB1 mutation in spinal meningioma represents branched evolution in a patient with multiple sporadic meningiomas
Gupta M, Samiappan S, Alanya H, Yalcin K, Gultekin B, Sharaf R, Elsamadicy A, Figuera D, Samuel N, Mishra-Gorur K, Kolb L, McGuone D, Gunel M, Erson-Omay E, Moliterno J, Mendel E. Somatic SMARCB1 mutation in spinal meningioma represents branched evolution in a patient with multiple sporadic meningiomas. Neuro-Oncology Advances 2025, 7: vdaf067. PMID: 40386121, PMCID: PMC12081948, DOI: 10.1093/noajnl/vdaf067.Peer-Reviewed Original Research
2024
Rapid Tumor DNA Analysis of Cerebrospinal Fluid Accelerates Treatment of Central Nervous System Lymphoma.
Gupta M, Bradley J, Massaad E, Burns E, Georgantas NZ, Maron G, Batten J, Gallagher A, Thierauf J, Nayyar N, Gordon A, Jones S, Pisapia M, Sun Y, Jones PS, Barker FG 2nd, Curry W, Gupta R, Romero J, Wang N, Brastianos P, Martinez-Lage M, Tateishi K, Forst DA, Nahed BV, Batchelor TT, Ritterhouse LL, Iser F, Kessler T, Jordan JT, Dietrich J, Meyerson ML, Cahill DP, Lennerz JK, Carter B, Shankar GM. Rapid Tumor DNA Analysis of Cerebrospinal Fluid Accelerates Treatment of Central Nervous System Lymphoma. Blood 2024 PMID: 38776489, DOI: 10.1182/blood.2024023832.Peer-Reviewed Original ResearchSickle cell disease in India: current status and progress
Jain D, Gupta M, Madkaikar M, Jena R, Khargekar N, Saraf S, Krishnamurti L, Gupta K. Sickle cell disease in India: current status and progress. The Lancet Haematology 2024, 11: e322-e323. PMID: 38701819, DOI: 10.1016/s2352-3026(24)00109-1.Peer-Reviewed Original ResearchRadical surgical resection with molecular margins is associated with improved survival in IDH wild-type glioblastoma
Massaad E, Smith W, Bradley J, Esposito E, Gupta M, Burns E, Burns R, Velarde J, Berglar I, Gupta R, Martinez-Lage M, Dietrich J, Lennerz J, Dunn G, Jones P, Choi B, Kim A, Frosch M, Barker F, Curry W, Carter B, Nahed B, Cahill D, Shankar G. Radical surgical resection with molecular margins is associated with improved survival in IDH wild-type glioblastoma. Neuro-Oncology 2024, 26: 1660-1669. PMID: 38581292, PMCID: PMC11376447, DOI: 10.1093/neuonc/noae073.Peer-Reviewed Original ResearchConceptsGross-total resectionSurgical marginsSurgical resectionMolecular marginsTERT mutationsDetection of TERT promoter mutationsResidual volumeTERT promoter mutation analysisIDH wild-type glioblastomaLocal control benefitRadical surgical resectionTERT promoter mutationsTumor cell contentIDH wild-typeWild-type glioblastomaArea under the curveMonths follow-upPromoter mutation analysisResection marginsTumor burdenRadical resectionTumor anatomyResection strategyFollow-upResection
Clinical Care
Overview
Mihir Gupta, MD, is a fellowship-trained spine surgeon with a background in neurosurgery and orthopaedics. He performs both traditional and minimally invasive procedures to treat an array of complex spinal disorders.
Dr. Gupta says he was drawn to spine surgery because of how quickly the field is evolving. “We finally have a much better understanding of why people have back or neck pain and how to make it better safely,” he says. “And that doesn’t always involve surgery. Our job is to figure out when surgery is appropriate, and more importantly, when it is not the best solution.”
Dr. Gupta treats a variety of spine conditions including those that are degenerative, deformative, or the result of tumors, infections, or trauma. He also performs revision spine surgeries, or surgeries for people who have had surgery in the past but have a persistent or new problem.
Before he walks in the exam room and meets a new patient, Dr. Gupta says he likes to do his homework and look through any imaging studies they brought. “That way, I can focus on listening to them and doing a very thorough physical exam,” he says. “A thoughtful evaluation and really good physical exam are vital for making an accurate diagnosis. Often, I think patients haven’t had their problem explained in a way that makes sense to them, and I prioritize that.”
Spine procedures, Dr. Gupta says, are highly personalized. “There isn’t a one-size-fits-all approach. Our diagnostics have come so far that we have better imaging that allows us to see where pain is coming from and if surgery is needed,” Dr. Gupta says. “We also have better tools now with robotics and navigation and minimally invasive methods. These all allow us to tailor the right solution for them.”
Surgery, he points out, is often the last resort and, in some cases, is not the right solution for a patient’s pain. “We work closely with the pain management team, anesthesiology, physical therapists, and interventional radiologists to come up with nonsurgical options,” he says.
Dr. Gupta’s research interests include understanding how genetics contribute to different spinal disorders and how care can be personalized.
Clinical Specialties
Fact Sheets
Minimally Invasive Spinal Surgery
Learn More on Yale MedicineMinimally Invasive Surgery
Learn More on Yale MedicineDegenerative and Rheumatologic Spinal Disorders
Learn More on Yale MedicineHalo-Gravity Traction
Learn More on Yale Medicine
Yale Medicine News
News
Get In Touch
Contacts
Administrative Support
Locations
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.