Jun He, PhD, MPH
he/him/his
Postdoctoral FellowAbout
Research
Publications
Featured Publications
Age-, Sex-, and Ancestry-Specific Prevalence of Hearing Loss in UK Biobank and All of Us Research Program
He J, Curhan S, Curhan G, Polimanti R. Age-, Sex-, and Ancestry-Specific Prevalence of Hearing Loss in UK Biobank and All of Us Research Program. Aging And Disease 2025, 17: 2253-2259. PMID: 40681351, PMCID: PMC13256383, DOI: 10.14336/ad.2025.0754.Peer-Reviewed Original ResearchUs Research ProgramPrevalence of HLHL prevalenceHearing lossPrevalence of hearing lossUK Biobank (UKBAge-standardized prevalenceIndividuals of diverse ancestral backgroundsElectronic health recordsPolygenic risk scoresAssociated with HLSelf-reported informationDiverse ancestral backgroundsGlobal disease burdenHealth recordsStandard populationUK BiobankPrevalence differencesUKBAncestry groupsRisk scoreDisease burdenEuropean descentAfrican descentSex differencesSex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias
He J, Cabrera‐Mendoza B, Friligkou E, Mecca A, van Dyck C, Pathak G, Polimanti R. Sex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias. Alzheimer's & Dementia 2025, 21: e70215. PMID: 40421744, PMCID: PMC12107445, DOI: 10.1002/alz.70215.Peer-Reviewed Original ResearchConceptsSocioeconomic factorsFamily historySocioeconomic statusFamily history of Alzheimer's diseaseAssociation of socioeconomic factorsHistory of Alzheimer's diseaseUs Research ProgramCognitive performanceHigher socioeconomic statusSex-specific associationsAlzheimer's Disease AssessmentSex differencesUK BiobankADRDAlzheimer's diseaseGenetically informed analysesDementiaSample sizeSexGenetic analysisAlzheimerLimited informationStatusConfoundingBiobankSex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation
He J, Cabrera-Mendoza B, De Angelis F, Pathak G, Koller D, Curhan S, Curhan G, Mecca A, van Dyck C, Polimanti R. Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation. Brain 2024, 147: 3395-3408. PMID: 38454550, PMCID: PMC11449129, DOI: 10.1093/brain/awae077.Peer-Reviewed Original ResearchImaging-derived phenotypesHearing difficultiesBrain imaging-derived phenotypesSex-combined analysisLatent causal variable analysesMendelian randomization approachGeneralized linear regression analysisLocal genetic correlation analysisMultivariate generalized linear regression analysisGenome-wide association studiesLatent causal variableGenetic correlation analysisGenetic correlationsLocal genetic correlationMendelian randomizationPeripheral auditory systemOlder adultsGWAS dataLinear regression analysisHealth burdenGenomic regionsAssociation studiesPleiotropic regionsSex differencesTranscriptome regulationTime Trends and Predictions of Suicide Mortality for People Aged 70 Years and Over From 1990 to 2030 Based on the Global Burden of Disease Study 2017
He J, Ouyang F, Qiu D, Li L, Li Y, Xiao S. Time Trends and Predictions of Suicide Mortality for People Aged 70 Years and Over From 1990 to 2030 Based on the Global Burden of Disease Study 2017. Frontiers In Psychiatry 2021, 12: 721343. PMID: 34646174, PMCID: PMC8502866, DOI: 10.3389/fpsyt.2021.721343.Peer-Reviewed Original ResearchSub-Saharan AfricaSuicide mortality ratesSocio-demographic IndexElderly mortality rateSuicide mortalitySuicide ratesMortality changesGlobal Burden of Disease StudySouthern Latin AmericaLatin AmericaBurden of Disease StudySub-SaharanWestern EuropeHighest suicide ratesSDGs indicatorsPrevention policiesTrends of suicide mortalityEast AsiaSouth KoreaAfricaCountriesReduce suicide ratesCzech RepublicGlobal burdenPeopleIncidence trends of major depressive disorder in China: an age-period-cohort modeling study
He J, Ouyang F, Li L, Qiu D, Li Y, Xiao S. Incidence trends of major depressive disorder in China: an age-period-cohort modeling study. Journal Of Affective Disorders 2021, 288: 10-16. PMID: 33839553, DOI: 10.1016/j.jad.2021.03.075.Peer-Reviewed Original ResearchConceptsYears age groupCohort effectsIncidence rateIncidence trendsMDD incidence ratesRate ratiosAge-standardized incidence rateGlobal Burden of Disease StudyAge groupsAge-period-cohort analysisMajor depressive disorder dataPeriod rate ratiosBurden of Disease StudyCohort rate ratiosMajor depressive disorderLongitudinal age curvesPublic health problemDepressive disorderBirth cohortMDD incidenceNet driftGlobal burdenHealth problemsIncidence dataDisease Study
2026
Observational and genetically-informed characterization of Gulf War Illness symptoms in 1990–1991 Gulf War deployed Veterans and non-deployed Gulf War Era Veterans
He J, Pathak G, Cabrera-Mendoza B, Qiu D, Zawack K, Steele L, Quaden R, Harrington K, Gifford E, Aslan M, Helmer D, Hauser E, Polimanti R. Observational and genetically-informed characterization of Gulf War Illness symptoms in 1990–1991 Gulf War deployed Veterans and non-deployed Gulf War Era Veterans. Environmental Health 2026 PMID: 42277823, DOI: 10.1186/s12940-026-01316-5.Peer-Reviewed Original ResearchNon-deployed veteransMillion Veteran ProgramGW-era veteransSymptom burdenPosttraumatic stress disorderPopulation-based case-control studyMethodsThis population-based case–control studyGW deploymentSymptom clustersMendelian randomization analysisHealth-related outcomesPolygenic risk scoresAssociated with demographic factorsActive-duty military personnelGulf War-era veteransBackgroundGulf War IllnessLower educational attainmentPosttraumatic stress disorder effectsHealth-related traitsMultivariate general linear modelNon-European descentCase-control studySymptom co-occurrenceT2D effectsVeteran ProgramBone Density Contributes to Lumbar Disc Herniation: A Mendelian Randomization Study
Adegbenro T, He J, Polimanti R, Margetis K. Bone Density Contributes to Lumbar Disc Herniation: A Mendelian Randomization Study. Spine Open 2026, 2: e0100. DOI: 10.1097/bn9.0000000000000100.Peer-Reviewed Original ResearchMultivariable Mendelian randomizationLumbar disc herniationMR-EggerMultivariable MRUK BiobankHigher bone mineral densityInverse-variance weighted MRLumbar disc herniation riskRisk of lumbar disc herniationDisc herniationMR-Egger interceptMendelian randomization studiesBone mineral densityGenetic epidemiological studiesLeave-one-out analysisMR-PRESSOMendelian randomizationWeighted modeReverse causationLumbar spine bone mineral densityGenetic variants associated with bone mineral densitySpine bone mineral densitySteiger's testOccupational activitiesReverse MRMulti-ancestry genome-wide association and integrated multi-omics analyses of endometriosis and its clinical manifestations
Koller D, He J, Løkhammer S, Aranda S, Qiu D, Davtian D, Chen Q, Xu Z, Mao Z, Friligkou E, Karaca S, Cormand B, Flores I, Altmäe S, Mitjans M, Cabrera-Mendoza B, Polimanti R. Multi-ancestry genome-wide association and integrated multi-omics analyses of endometriosis and its clinical manifestations. Nature Genetics 2026, 58: 1051-1061. PMID: 42056605, PMCID: PMC13195585, DOI: 10.1038/s41588-026-02582-2.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenome-wide associationMulti-omics dataDrug repurposing analysisLocus discoveryGenetic risk factorsPreterm birth preventionAssociated with adenomyosisMolecular supportGenetic basisProteomic analysisChronic systemic diseaseStudy of endometriosisMolecular mechanismsCell differentiationAbdominal painHormonal regulationClinical manifestationsBreast cancerLociEndometriosisSystemic diseasePolygenic riskEndometriosis riskRisk factorsPFNA dominates the association between PFAS mixture exposure and hypertension risk: The mediating role of estradiol in the U.S. adults
Li L, Li M, Jiang J, Wang J, Zhu L, Jiang N, He X, Liu H, Wang S, He J, Zhang Q, Hong X. PFNA dominates the association between PFAS mixture exposure and hypertension risk: The mediating role of estradiol in the U.S. adults. Ecotoxicology And Environmental Safety 2026, 316: 120124. PMID: 41967265, DOI: 10.1016/j.ecoenv.2026.120124.Peer-Reviewed Original ResearchConceptsPolyfluoroalkyl substancesRestricted cubic splinesHypertension riskPerfluorooctanoic acidPerfluorononanoic acidWeighted quantile sumNational Health and Nutrition Examination SurveyU.S. National Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyLong-chain PFASsEndocrine-disrupting mechanismsNutrition Examination SurveyComplex survey designEnvironmental risk assessmentSex-stratified analysesWeighted quantile sum regressionPFAS mixture exposureExamination SurveyAssociated with hypertensionU.S. adultsMixture exposureEndocrine-disruptingMixture effectsPFAS mixturePFAS mixturesGenomic interplay between deployment exposures and Gulf War illness in Million Veteran Program participants
Qiu D, Cabrera-Mendoza B, He J, Steele L, Quaden R, Harrington K, Ahmed S, Gaziano J, Gifford E, Aslan M, Helmer D, Hauser E, Polimanti R. Genomic interplay between deployment exposures and Gulf War illness in Million Veteran Program participants. Human Genomics 2026, 20: 82. PMID: 41896945, PMCID: PMC13147720, DOI: 10.1186/s40246-026-00951-w.Peer-Reviewed Original ResearchConceptsGulf War IllnessEpigenetic interactionsDeployment exposuresGenome-wide significant interactionBurden of chronic health conditionsElevated burdenMillion Veteran Program participantsEpigenome-wide association studiesGW deploymentChronic health conditionsGW exposuresDrug repurposing analysisGenomic interplayAssociation studiesMilitary exposuresHealth conditionsRisk associationEpigenetic factorsProgram participantsGW-deployed veteransDruggable pathwaysVeteransMolecular pathwaysGenetic susceptibilityDisease etiology
Academic Achievements & Community Involvement
News
News
- April 29, 2026
Largest-Ever Genetic Study of Endometriosis Uncovers 80 Risk Regions and New Avenues for Treatment
- May 27, 2025
Yale Scientists Uncover Sex Differences in Recalling and Reporting of Family History of Alzheimer’s Disease
- September 19, 2024
Yale Scientists Uncover Genetic Predisposition to Anxiety
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