2020
Enhanced Recovery Programs for Colorectal Surgery and Postoperative Acute Kidney Injury: Results From a Systematic Review and Meta-Analysis of Observational Studies
Zorrilla-Vaca A, Mena G, Cata J, Healy R, Grant M. Enhanced Recovery Programs for Colorectal Surgery and Postoperative Acute Kidney Injury: Results From a Systematic Review and Meta-Analysis of Observational Studies. The American Surgeon 2020, 87: 1444-1451. PMID: 33375852, DOI: 10.1177/0003134820954846.Peer-Reviewed Original ResearchConceptsPostoperative acute kidney injuryAcute kidney injuryObservational studyKidney injuryColorectal surgeryConventional careSystematic reviewHigh-risk patient populationConventional perioperative carePerioperative health careRestrictive fluid administrationEnhanced recovery programmeRisk patient populationEvidence-based measuresHemodynamic goalsPostoperative recoveryERP patientsPerioperative careFluid administrationNephrotoxic agentsPatient populationPooled resultsGreater oddsRecovery programMeta-AnalysisGoal-Directed Fluid Therapy and Postoperative Outcomes in an Enhanced Recovery Program for Colorectal Surgery: A Propensity Score-Matched Multicenter Study
Zorrilla-Vaca A, Mena G, Ripolles-Melchor J, Abad-Motos A, Aldecoa C, Lorente J, Ramirez-Rodriguez J, Grant M. Goal-Directed Fluid Therapy and Postoperative Outcomes in an Enhanced Recovery Program for Colorectal Surgery: A Propensity Score-Matched Multicenter Study. The American Surgeon 2020, 87: 1189-1195. PMID: 33342254, DOI: 10.1177/0003134820973365.Peer-Reviewed Original ResearchConceptsGoal-directed fluid therapyEnhanced recovery programmeAcute kidney injurySurgical site infectionColorectal surgeryPostoperative outcomesFluid therapyPostoperative acute kidney injuryPropensity score-matched analysisComparable baseline demographicsMajor postoperative outcomesAdequate tissue perfusionRates of morbidityHospital stayKidney injuryBaseline demographicsCohort studyConventional careERAS programAnastomotic dehiscenceMajor surgerySite infectionPulmonary edemaMulticenter studyTherapy patientsRisk factors for acute kidney injury in an enhanced recovery pathway for colorectal surgery
Zorrilla-Vaca A, Mena G, Ripolles-Melchor J, Lorente J, Ramirez-Rodriguez J, Grant M. Risk factors for acute kidney injury in an enhanced recovery pathway for colorectal surgery. Surgery Today 2020, 51: 537-544. PMID: 32785846, DOI: 10.1007/s00595-020-02107-2.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAge FactorsAgedAged, 80 and overColonCreatinineDigestive System Surgical ProceduresEnhanced Recovery After SurgeryFemaleHumansMaleMalnutritionMiddle AgedMulticenter Studies as TopicNutritional StatusPostoperative ComplicationsProspective StudiesRectumRisk FactorsROC CurveSerum AlbuminConceptsPostoperative acute kidney injuryAcute kidney injuryColorectal surgeryRisk factorsKidney injuryLow preoperative albumin levelRecovery pathwaysPerioperative patient outcomesPreoperative albumin levelEnhanced recovery pathwayIndependent risk factorProspective cohort studyPoor clinical outcomeDirect healthcare costsOpen surgical approachMalnourished patientsCohort studyAlbumin levelsASA IIILarge multicenterPreoperative interventionClinical outcomesMultivariable analysisOverall incidenceModifiable factors
2008
Is Aprotinin Safe to Use in a Cohort at Increased Risk for Thrombotic Events: Results From a Randomized, Prospective Trial in Off-Pump Coronary Artery Bypass
Grant M, Kon Z, Joshi A, Christenson E, Kallam S, Burris N, Gu J, Poston R. Is Aprotinin Safe to Use in a Cohort at Increased Risk for Thrombotic Events: Results From a Randomized, Prospective Trial in Off-Pump Coronary Artery Bypass. The Annals Of Thoracic Surgery 2008, 86: 815-822. PMID: 18721566, PMCID: PMC2649734, DOI: 10.1016/j.athoracsur.2008.04.047.Peer-Reviewed Original ResearchConceptsAcute kidney injuryCoronary artery bypassThrombotic eventsAprotinin levelsAprotinin useArtery bypassDay 3Off-pump coronary artery bypassMore acute kidney injuryPostoperative acute kidney injurySubsequent acute kidney injuryPump coronary artery bypassAcute graft failureAdverse thrombotic eventsWeight-based protocolPercentage of patientsGlomerular filtration rateFavorable safety profileMultiple randomized trialsPostoperative hypercoagulable stateEGFR declineCerebrovascular eventsKidney injuryLower eGFRPlacebo group