2024
Childhood physical activity and pubertal timing: findings from the LEGACY girls study
Kehm R, Knight J, Houghton L, McDonald J, Schwartz L, Goldberg M, Chung W, Frost C, Wei Y, Bradbury A, Keegan T, Daly M, Buys S, Andrulis I, John E, Terry M. Childhood physical activity and pubertal timing: findings from the LEGACY girls study. International Journal Of Epidemiology 2024, 53: dyad193. PMID: 38205889, PMCID: PMC10859159, DOI: 10.1093/ije/dyad193.Peer-Reviewed Original ResearchConceptsBreast cancer family historyBody mass index-for-age z-scorePhysical activityChildhood physical activityCancer family historyLEGACY Girls StudyAssociated with later menarcheParametric survival regression modelsOrganized PAMetabolic equivalentsInverse oddsEarly childhoodSociodemographic factorsEffect modificationAssociated with ageLater menarcheNorth American cohortFamily historySurvival regression modelsStudy enrollmentMiddle childhoodAmerican cohortQuestionnaire dataPotential mediatorsZ-score
2010
Hereditary breast and ovarian cancer due to mutations in BRCA1 and BRCA2
Petrucelli N, Daly M, Feldman G. Hereditary breast and ovarian cancer due to mutations in BRCA1 and BRCA2. Genetics In Medicine 2010, 12: 245-259. PMID: 20216074, DOI: 10.1097/gim.0b013e3181d38f2f.Peer-Reviewed Original ResearchConceptsBRCA1/2 mutationsBRCA2 mutationsHereditary breastTesting of at-risk relativesFamily history of cancerOvarian cancerAt-risk relativesPrimary prevention optionsHistory of cancerPrevalence of BRCA1/2 mutationsEstimates of penetranceAshkenazi Jewish populationCancer riskProphylactic surgeryPrevention optionsFamily historyBRCA2 genesEarly interventionFamily membersBRCA2Increased surveillanceFamilial mutationsBRCA1/2BRCA1Jewish population