2022
Common variants in breast cancer risk loci predispose to distinct tumor subtypes
Ahearn T, Zhang H, Michailidou K, Milne R, Bolla M, Dennis J, Dunning A, Lush M, Wang Q, Andrulis I, Anton-Culver H, Arndt V, Aronson K, Auer P, Augustinsson A, Baten A, Becher H, Behrens S, Benitez J, Bermisheva M, Blomqvist C, Bojesen S, Bonanni B, Børresen-Dale A, Brauch H, Brenner H, Brooks-Wilson A, Brüning T, Burwinkel B, Buys S, Canzian F, Castelao J, Chang-Claude J, Chanock S, Chenevix-Trench G, Clarke C, Collée J, Cox A, Cross S, Czene K, Daly M, Devilee P, Dörk T, Dwek M, Eccles D, Evans D, Fasching P, Figueroa J, Floris G, Gago-Dominguez M, Gapstur S, García-Sáenz J, Gaudet M, Giles G, Goldberg M, González-Neira A, Alnæs G, Grip M, Guénel P, Haiman C, Hall P, Hamann U, Harkness E, Heemskerk-Gerritsen B, Holleczek B, Hollestelle A, Hooning M, Hoover R, Hopper J, Howell A, Jakimovska M, Jakubowska A, John E, Jones M, Jung A, Kaaks R, Kauppila S, Keeman R, Khusnutdinova E, Kitahara C, Ko Y, Koutros S, Kristensen V, Krüger U, Kubelka-Sabit K, Kurian A, Kyriacou K, Lambrechts D, Lee D, Lindblom A, Linet M, Lissowska J, Llaneza A, Lo W, MacInnis R, Mannermaa A, Manoochehri M, Margolin S, Martinez M, McLean C, Meindl A, Menon U, Nevanlinna H, Newman W, Nodora J, Offit K, Olsson H, Orr N, Park-Simon T, Patel A, Peto J, Pita G, Plaseska-Karanfilska D, Prentice R, Punie K, Pylkäs K, Radice P, Rennert G, Romero A, Rüdiger T, Saloustros E, Sampson S, Sandler D, Sawyer E, Schmutzler R, Schoemaker M, Schöttker B, Sherman M, Shu X, Smichkoska S, Southey M, Spinelli J, Swerdlow A, Tamimi R, Tapper W, Taylor J, Teras L, Terry M, Torres D, Troester M, Vachon C, van Deurzen C, van Veen E, Wagner P, Weinberg C, Wendt C, Wesseling J, Winqvist R, Wolk A, Yang X, Zheng W, Couch F, Simard J, Kraft P, Easton D, Pharoah P, Schmidt M, García-Closas M, Chatterjee N. Common variants in breast cancer risk loci predispose to distinct tumor subtypes. Breast Cancer Research 2022, 24: 2. PMID: 34983606, PMCID: PMC8725568, DOI: 10.1186/s13058-021-01484-x.Peer-Reviewed Original Research
2011
Large Prospective Study of Ovarian Cancer Screening in High-Risk Women: CA125 Cut-Point Defined by Menopausal Status
Skates S, Mai P, Horick N, Piedmonte M, Drescher C, Isaacs C, Armstrong D, Buys S, Rodriguez G, Horowitz I, Berchuck A, Daly M, Domchek S, Cohn D, Van Le L, Schorge J, Newland W, Davidson S, Barnes M, Brewster W, Azodi M, Nerenstone S, Kauff N, Fabian C, Sluss P, Nayfield S, Kasten C, Finkelstein D, Greene M, Lu K. Large Prospective Study of Ovarian Cancer Screening in High-Risk Women: CA125 Cut-Point Defined by Menopausal Status. Cancer Prevention Research 2011, 4: 1401-1408. PMID: 21893500, PMCID: PMC3172691, DOI: 10.1158/1940-6207.capr-10-0402.Peer-Reviewed Original ResearchConceptsHigh-risk womenCut-pointsMenopausal statusScreening TrialOvarian Cancer Screening TrialOvarian cancer screening studiesPopulation of high-risk womenOvarian cancer screeningPremenopausal womenStandard cut-pointCancer Screening TrialCancer screening studyEffect of menopausal statusPostmenopausal subjectsClinical factorsScreening studiesOral contraceptivesCancer screeningEarly detection of ovarian cancerCA125 testDetection of ovarian cancerGynecologic Oncology GroupEligibility criteriaScreening protocolDemographic dataModification of BRCA1-Associated Breast and Ovarian Cancer Risk by BRCA1-Interacting Genes
Rebbeck T, Mitra N, Domchek S, Wan F, Friebel T, Tran T, Singer C, Tea M, Blum J, Tung N, Olopade O, Weitzel J, Lynch H, Snyder C, Garber J, Antoniou A, Peock S, Evans D, Paterson J, Kennedy M, Donaldson A, Dorkins H, Easton D, Rubinstein W, Daly M, Isaacs C, Nevanlinna H, Couch F, Andrulis I, Freidman E, Laitman Y, Ganz P, Tomlinson G, Neuhausen S, Narod S, Phelan C, Greenberg R, Nathanson K. Modification of BRCA1-Associated Breast and Ovarian Cancer Risk by BRCA1-Interacting Genes. Cancer Research 2011, 71: 5792-5805. PMID: 21799032, PMCID: PMC3170727, DOI: 10.1158/0008-5472.can-11-0773.Peer-Reviewed Original ResearchConceptsOvarian cancer riskCancer riskAssociation of haplotypesAssociated with ovarian cancer riskBreast cancerBRCA1 mutationsModifiers of cancer riskFalse discovery rateEncode proteinsBRCA1-associated breast cancerElevated cancer riskBRCA1 mutation carriersInherited BRCA1 mutationsOvarian cancer diagnosisSignificant false discovery rateAssociated with timeCancer diagnosisMutation carriersGenomic variationMultiple lociBRCA1BRCC45BreastCancerGenes