Karen Agaronyan
Associate Research ScientistCards
About
Research
Publications
2025
Damage sensing through TLR9 regulates inflammatory and antiviral responses during influenza infection
Kim J, Yuan Y, Agaronyan K, Zhao A, Wang V, Gau D, Toosi N, Gupta G, Essayas H, Kaminski A, McGovern J, Yu S, Woo S, Lee C, Gandhi S, Saber T, Saleh T, Hu B, Sun Y, Ishikawa G, Bain W, Evankovich J, Chen L, Yun H, Herzog E, Dela Cruz C, Ryu C, Sharma L. Damage sensing through TLR9 regulates inflammatory and antiviral responses during influenza infection. Mucosal Immunology 2025, 18: 537-548. PMID: 39884393, PMCID: PMC12205908, DOI: 10.1016/j.mucimm.2025.01.008.Peer-Reviewed Original Research
2023
Modes of type 2 immune response initiation
Kopp E, Agaronyan K, Licona-Limón I, Nish S, Medzhitov R. Modes of type 2 immune response initiation. Immunity 2023, 56: 687-694. PMID: 37044059, DOI: 10.1016/j.immuni.2023.03.015.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2019
Author Correction: Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations
Kang E, Wu J, Gutierrez N, Koski A, Tippner-Hedges R, Agaronyan K, Platero-Luengo A, Martinez-Redondo P, Ma H, Lee Y, Hayama T, Van Dyken C, Wang X, Luo S, Ahmed R, Li Y, Ji D, Kayali R, Cinnioglu C, Olson S, Jensen J, Battaglia D, Lee D, Wu D, Huang T, Wolf D, Temiakov D, Belmonte J, Amato P, Mitalipov S. Author Correction: Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations. Nature 2019, 567: e5-e9. PMID: 30814738, DOI: 10.1038/s41586-019-0876-1.Commentaries, Editorials and Letters
2017
Mechanism of Transcription Anti-termination in Human Mitochondria
Hillen H, Parshin A, Agaronyan K, Morozov Y, Graber J, Chernev A, Schwinghammer K, Urlaub H, Anikin M, Cramer P, Temiakov D. Mechanism of Transcription Anti-termination in Human Mitochondria. Cell 2017, 171: 1082-1093.e13. PMID: 29033127, PMCID: PMC5798601, DOI: 10.1016/j.cell.2017.09.035.Peer-Reviewed Original Research
2016
Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations
Kang E, Wu J, Gutierrez N, Koski A, Tippner-Hedges R, Agaronyan K, Platero-Luengo A, Martinez-Redondo P, Ma H, Lee Y, Hayama T, Van Dyken C, Wang X, Luo S, Ahmed R, Li Y, Ji D, Kayali R, Cinnioglu C, Olson S, Jensen J, Battaglia D, Lee D, Wu D, Huang T, Wolf D, Temiakov D, Belmonte J, Amato P, Mitalipov S. Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations. Nature 2016, 540: 270-275. PMID: 27919073, DOI: 10.1038/nature20592.Commentaries, Editorials and Letters
2015
A model for transcription initiation in human mitochondria
Morozov Y, Parshin A, Agaronyan K, Cheung A, Anikin M, Cramer P, Temiakov D. A model for transcription initiation in human mitochondria. Nucleic Acids Research 2015, 43: 3726-3735. PMID: 25800739, PMCID: PMC4402542, DOI: 10.1093/nar/gkv235.Peer-Reviewed Original ResearchReplication-transcription switch in human mitochondria
Agaronyan K, Morozov Y, Anikin M, Temiakov D. Replication-transcription switch in human mitochondria. Science 2015, 347: 548-551. PMID: 25635099, PMCID: PMC4677687, DOI: 10.1126/science.aaa0986.Peer-Reviewed Original Research
2014
A novel intermediate in transcription initiation by human mitochondrial RNA polymerase
Morozov Y, Agaronyan K, Cheung A, Anikin M, Cramer P, Temiakov D. A novel intermediate in transcription initiation by human mitochondrial RNA polymerase. Nucleic Acids Research 2014, 42: 3884-3893. PMID: 24393772, PMCID: PMC3973326, DOI: 10.1093/nar/gkt1356.Peer-Reviewed Original Research
2013
Structure of human mitochondrial RNA polymerase elongation complex
Schwinghammer K, Cheung A, Morozov Y, Agaronyan K, Temiakov D, Cramer P. Structure of human mitochondrial RNA polymerase elongation complex. Nature Structural & Molecular Biology 2013, 20: 1298-1303. PMID: 24096365, PMCID: PMC4321815, DOI: 10.1038/nsmb.2683.Peer-Reviewed Original Research
2010
NADPH oxidase controls EGF-induced proliferation via an ERK1/2-independent mechanism
Tyurin-Kuzmin P, Agaronyan K, Morozov Y, Mishina N, Belousov V, Vorotnikov A. NADPH oxidase controls EGF-induced proliferation via an ERK1/2-independent mechanism. Biophysics 2010, 55: 959-965. DOI: 10.1134/s0006350910060126.Peer-Reviewed Original Research