Elizabeth Kopp, PhD, BA
Research ScientistCards
About
Research
Publications
2025
Regulation of inflammatory responses by pH-dependent transcriptional condensates
Wu Z, Pope S, Ahmed N, Leung D, Hong Y, Hajjar S, Krabak C, Zhong Z, Raghunathan K, Yue Q, Anand D, Kopp E, Okin D, Ma W, Zanoni I, Kagan J, Thiagarajah J, Hargreaves D, Medzhitov R, Zhou X. Regulation of inflammatory responses by pH-dependent transcriptional condensates. Cell 2025, 188: 5632-5652.e25. PMID: 40680734, PMCID: PMC12313145, DOI: 10.1016/j.cell.2025.06.033.Peer-Reviewed Original Research
2023
Modes of type 2 immune response initiation
Kopp E, Agaronyan K, Licona-Limón I, Nish S, Medzhitov R. Modes of type 2 immune response initiation. Immunity 2023, 56: 687-694. PMID: 37044059, DOI: 10.1016/j.immuni.2023.03.015.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2009
PERSPECTIVE: Infection and inflammation in somatic maintenance, growth and longevity
Kopp EB, Medzhitov R. PERSPECTIVE: Infection and inflammation in somatic maintenance, growth and longevity. Evolutionary Applications 2009, 2: 132-141. PMID: 25567853, PMCID: PMC3352410, DOI: 10.1111/j.1752-4571.2008.00062.x.Peer-Reviewed Original Research
2006
Vaccination with recombinant fusion proteins incorporating Toll-like receptor ligands induces rapid cellular and humoral immunity
Huleatt JW, Jacobs AR, Tang J, Desai P, Kopp EB, Huang Y, Song L, Nakaar V, Powell TJ. Vaccination with recombinant fusion proteins incorporating Toll-like receptor ligands induces rapid cellular and humoral immunity. Vaccine 2006, 25: 763-775. PMID: 16968658, DOI: 10.1016/j.vaccine.2006.08.013.Peer-Reviewed Original Research
2003
Recognition of microbial infection by Toll-like receptors
Kopp E, Medzhitov R. Recognition of microbial infection by Toll-like receptors. Current Opinion In Immunology 2003, 15: 396-401. PMID: 12900270, DOI: 10.1016/s0952-7915(03)00080-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2002
Skin antibiotics get in the loop
Kopp E, Medzhitov R. Skin antibiotics get in the loop. Nature Medicine 2002, 8: 1359-1360. PMID: 12457178, DOI: 10.1038/nm1202-1359.Peer-Reviewed Original ResearchA Plague on Host Defense
Kopp E, Medzhitov R. A Plague on Host Defense. Journal Of Experimental Medicine 2002, 196: 1009-1012. PMID: 12391011, PMCID: PMC2194040, DOI: 10.1084/jem.20021311.Peer-Reviewed Original Research
2000
Transcriptional Activation of the Cyclooxygenase-2 Gene in Endotoxin-treated RAW 264.7 Macrophages*
Wadleigh D, Reddy S, Kopp E, Ghosh S, Herschman H. Transcriptional Activation of the Cyclooxygenase-2 Gene in Endotoxin-treated RAW 264.7 Macrophages*. Journal Of Biological Chemistry 2000, 275: 6259-6266. PMID: 10692422, DOI: 10.1074/jbc.275.9.6259.Peer-Reviewed Original ResearchAdaptor Proteins, Signal TransducingAnimalsCCAAT-Enhancer-Binding ProteinsCyclic AMPCyclooxygenase 2DNA-Binding ProteinsDrosophila ProteinsEndotoxinsGenes, ReporterI-kappa B ProteinsIsoenzymesJNK Mitogen-Activated Protein KinasesLipopolysaccharidesMacrophagesMAP Kinase Kinase Kinase 1MiceMitogen-Activated Protein KinasesMutationNuclear ProteinsPhosphorylationPromoter Regions, GeneticProstaglandin-Endoperoxide SynthasesProtein Serine-Threonine KinasesProteinsProto-Oncogene Proteins c-junSignal TransductionTranscriptional Activation
1999
ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
Kopp E, Medzhitov R, Carothers J, Xiao C, Douglas I, Janeway C, Ghosh S. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes & Development 1999, 13: 2059-2071. PMID: 10465784, PMCID: PMC316957, DOI: 10.1101/gad.13.16.2059.Peer-Reviewed Original ResearchAdaptor Proteins, Signal TransducingAmino Acid SequenceAnimalsBiological EvolutionCell Line, TransformedCloning, MolecularDrosophilaDrosophila ProteinsEnzyme ActivationHumansInsect ProteinsMAP Kinase Kinase Kinase 1Membrane GlycoproteinsMiceMolecular Sequence DataNF-kappa BProtein Processing, Post-TranslationalProtein Serine-Threonine KinasesProteinsReceptors, Cell SurfaceReceptors, ImmunologicReceptors, Interleukin-1Saccharomyces cerevisiaeSignal TransductionTNF Receptor-Associated Factor 6Toll-Like ReceptorsThe Toll-receptor family and control of innate immunity
Kopp E, Medzhitov R. The Toll-receptor family and control of innate immunity. Current Opinion In Immunology 1999, 11: 13-18. PMID: 10047546, DOI: 10.1016/s0952-7915(99)80003-x.Peer-Reviewed Original Research