Jeff Gehlhausen, MD, PhD
Assistant Professor in DermatologyCards
About
Dr. Jeff Gehlhausen, MD, PhD, is a dermatologist at Yale Medicine in New Haven, Connecticut. He specializes in caring for patients with complex autoimmune skin conditions such as cutaneous lupus, dermatomyositis, and vasculitis.
Research
Overview
Medical Research Interests
Autoimmune Diseases; Connective Tissue Diseases; Dermatology; Dermatomyositis; Informatics; Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Discoid; Panniculitis, Lupus Erythematosus; Pathology; Raynaud Disease; Skin and Connective Tissue Diseases; Vasculitis
Public Health Interests
Immunology
Publications
2024
Lupus erythematosus and dermatomyositis
Ramachandran S, Little A, Gehlhausen J. Lupus erythematosus and dermatomyositis. Clinics In Dermatology 2024 PMID: 39694200, DOI: 10.1016/j.clindermatol.2024.12.009.Peer-Reviewed Original ResearchLupus erythematosusSystemic diseaseTraining of dermatologistsManifestation of systemic diseaseSymptoms of systemic lupus erythematosusCutaneous manifestations of systemic diseaseAutoimmune connective tissue diseaseSystemic lupus erythematosusConnective tissue diseaseSigns of systemic diseasePatient carePhysical examination findingsInternal medicineCutaneous manifestationsYoung dermatologistsTissue diseaseClinicopathologic correlationPathological findingsExamination findingsSkin signsSystem pathologyField of dermatologyClinical signsObservation skillsIntranasal neomycin evokes broad-spectrum antiviral immunity in the upper respiratory tract
Mao T, Kim J, Peña-Hernández M, Valle G, Moriyama M, Luyten S, Ott I, Gomez-Calvo M, Gehlhausen J, Baker E, Israelow B, Slade M, Sharma L, Liu W, Ryu C, Korde A, Lee C, Monteiro V, Lucas C, Dong H, Yang Y, Initiative Y, Gopinath S, Wilen C, Palm N, Dela Cruz C, Iwasaki A, Vogels C, Hahn A, Chen N, Breban M, Koch T, Chaguza C, Tikhonova I, Castaldi C, Mane S, De Kumar B, Ferguson D, Kerantzas N, Peaper D, Landry M, Schulz W, Grubaugh N. Intranasal neomycin evokes broad-spectrum antiviral immunity in the upper respiratory tract. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2319566121. PMID: 38648490, PMCID: PMC11067057, DOI: 10.1073/pnas.2319566121.Peer-Reviewed Original ResearchConceptsInterferon-stimulated genesRespiratory infectionsStrains of influenza A virusTreatment of respiratory viral infectionsRespiratory virus infectionsInfluenza A virusMouse model of COVID-19Respiratory viral infectionsNeomycin treatmentExpression of interferon-stimulated genesUpper respiratory infectionInterferon-stimulated gene expressionLower respiratory infectionsBroad spectrum of diseasesAdministration of neomycinRespiratory viral diseasesDisease to patientsUpper respiratory tractIntranasal deliveryCongenic miceIntranasal applicationNasal mucosaSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2A virus
2023
Cancer Relevance of Circulating Antibodies Against LINE-1 Antigens in Humans
Vylegzhanina A, Bespalov I, Novototskaya-Vlasova K, Hall B, Gleiberman A, Yu H, Leontieva O, Leonova K, Kurnasov O, Osterman A, Dy G, Komissarov A, Vasilieva E, Gehlhausen J, Iwasaki A, Ambrosone C, Tsuji T, Matsuzaki J, Odunsi K, Andrianova E, Gudkov A. Cancer Relevance of Circulating Antibodies Against LINE-1 Antigens in Humans. Cancer Research Communications 2023, 3: 2256-2267. PMID: 37870410, PMCID: PMC10631453, DOI: 10.1158/2767-9764.crc-23-0289.Peer-Reviewed Original ResearchConceptsL1 antigenCancer typesDisease stage 1Discovery of autoantibodiesHigh IgG titersTumor-associated antigensDetermination of immunoreactivityTumor immunoreactivityCirculating AntibodiesIgG titersAntibody responseImmune responseLiver cancerReactive IgGHealthy individualsCurable cancer typesImmune systemAntigenNormal tissuesPatientsCancerEarly detectionElevated levelsCarcinogenic processAutoantibodiesDistinguishing features of long COVID identified through immune profiling
Klein J, Wood J, Jaycox J, Dhodapkar R, Lu P, Gehlhausen J, Tabachnikova A, Greene K, Tabacof L, Malik A, Silva Monteiro V, Silva J, Kamath K, Zhang M, Dhal A, Ott I, Valle G, Peña-Hernández M, Mao T, Bhattacharjee B, Takahashi T, Lucas C, Song E, McCarthy D, Breyman E, Tosto-Mancuso J, Dai Y, Perotti E, Akduman K, Tzeng T, Xu L, Geraghty A, Monje M, Yildirim I, Shon J, Medzhitov R, Lutchmansingh D, Possick J, Kaminski N, Omer S, Krumholz H, Guan L, Dela Cruz C, van Dijk D, Ring A, Putrino D, Iwasaki A. Distinguishing features of long COVID identified through immune profiling. Nature 2023, 623: 139-148. PMID: 37748514, PMCID: PMC10620090, DOI: 10.1038/s41586-023-06651-y.Peer-Reviewed Original ResearchConceptsLong COVIDSARS-CoV-2Infection syndromeExaggerated humoral responseSoluble immune mediatorsEpstein-Barr virusPost-exertional malaiseCross-sectional studyHigher antibody responseImmune mediatorsImmune phenotypingImmune profilingHumoral responseAntibody responseLymphocyte populationsCOVID statusUnbiased machineCortisol levelsLC statusRelevant biomarkersViral pathogensSyndromeCOVIDFuture studiesBiological featuresAssociation of psoriasis and systemic lupus erythematosus and mediation effects of tumor necrosis factor-α inhibitors: A cross-sectional study in the All of Us Research Program
Chen G, Hong S, Ramachandran S, Gehlhausen J, Cohen J. Association of psoriasis and systemic lupus erythematosus and mediation effects of tumor necrosis factor-α inhibitors: A cross-sectional study in the All of Us Research Program. Journal Of The American Academy Of Dermatology 2023, 90: 184-187. PMID: 37734665, DOI: 10.1016/j.jaad.2023.09.028.Peer-Reviewed Original ResearchVascular-Targeted Therapy for Systemic Lupus Erythematosus–Associated Vasculitis
Xu S, Patrignelli R, Ramachandran S, Koumpouras F, Desir D, Ko C, Gehlhausen J. Vascular-Targeted Therapy for Systemic Lupus Erythematosus–Associated Vasculitis. JAMA Dermatology 2023, 159: 460-462. PMID: 36884229, DOI: 10.1001/jamadermatol.2023.0077.Peer-Reviewed Original Research
2022
Random skin biopsies for diagnosis of intravascular large B-cell lymphoma: Retrospective analysis of 31 biopsies from a US dermatology inpatient consultative service with literature review
Kim SR, Ko CJ, Nelson CA, Ramachandran S, Gehlhausen JR. Random skin biopsies for diagnosis of intravascular large B-cell lymphoma: Retrospective analysis of 31 biopsies from a US dermatology inpatient consultative service with literature review. Journal Of The American Academy Of Dermatology 2022, 88: 714-716. PMID: 36152693, DOI: 10.1016/j.jaad.2022.09.016.Peer-Reviewed Original ResearchMild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation
Fernández-Castañeda A, Lu P, Geraghty AC, Song E, Lee MH, Wood J, O'Dea MR, Dutton S, Shamardani K, Nwangwu K, Mancusi R, Yalçın B, Taylor KR, Acosta-Alvarez L, Malacon K, Keough MB, Ni L, Woo PJ, Contreras-Esquivel D, Toland AMS, Gehlhausen JR, Klein J, Takahashi T, Silva J, Israelow B, Lucas C, Mao T, Peña-Hernández MA, Tabachnikova A, Homer RJ, Tabacof L, Tosto-Mancuso J, Breyman E, Kontorovich A, McCarthy D, Quezado M, Vogel H, Hefti MM, Perl DP, Liddelow S, Folkerth R, Putrino D, Nath A, Iwasaki A, Monje M. Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation. Cell 2022, 185: 2452-2468.e16. PMID: 35768006, PMCID: PMC9189143, DOI: 10.1016/j.cell.2022.06.008.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionMicroglial reactivityCognitive impairmentCSF cytokines/chemokinesCytokines/chemokinesSARS-CoV-2Early time pointsCCL11 levelsMild COVIDRespiratory influenzaHippocampal neurogenesisOligodendrocyte lossHippocampal pathologyMyelin lossNeurological symptomsImpaired neurogenesisCOVID survivorsNeurobiological effectsNeural dysregulationMyelin dysregulationCCL11Neural cellsTime pointsNeurogenesisMiceNot all well-differentiated cutaneous squamous cell carcinomas are equal: Tumors with disparate biologic behavior have differences in protein expression via digital spatial profiling
Vesely M, Martinez-Morilla S, Gehlhausen JR, McNiff JM, Whang PG, Rimm D, Ko CJ. Not all well-differentiated cutaneous squamous cell carcinomas are equal: Tumors with disparate biologic behavior have differences in protein expression via digital spatial profiling. Journal Of The American Academy Of Dermatology 2022, 87: 695-698. PMID: 35398219, DOI: 10.1016/j.jaad.2022.03.057.Peer-Reviewed Original ResearchLack of association between pandemic chilblains and SARS-CoV-2 infection
Gehlhausen JR, Little AJ, Ko CJ, Emmenegger M, Lucas C, Wong P, Klein J, Lu P, Mao T, Jaycox J, Wang E, Ugwu N, Muenker C, Mekael D, Klein R, Patrignelli R, Antaya R, McNiff J, Damsky W, Kamath K, Shon J, Ring A, Yildirim I, Omer S, Ko A, Aguzzi A, Iwasaki A, Obaid A, Lu-Culligan A, Nelson A, Brito A, Nunez A, Martin A, Watkins A, Geng B, Kalinich C, Harden C, Todeasa C, Jensen C, Kim D, McDonald D, Shepard D, Courchaine E, White E, Song E, Silva E, Kudo E, DeIuliis G, Rahming H, Park H, Matos I, Nouws J, Valdez J, Fauver J, Lim J, Rose K, Anastasio K, Brower K, Glick L, Sharma L, Sewanan L, Knaggs L, Minasyan M, Batsu M, Petrone M, Kuang M, Nakahata M, Campbell M, Linehan M, Askenase M, Simonov M, Smolgovsky M, Sonnert N, Naushad N, Vijayakumar P, Martinello R, Datta R, Handoko R, Bermejo S, Prophet S, Bickerton S, Velazquez S, Alpert T, Rice T, Khoury-Hanold W, Peng X, Yang Y, Cao Y, Strong Y. Lack of association between pandemic chilblains and SARS-CoV-2 infection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2122090119. PMID: 35217624, PMCID: PMC8892496, DOI: 10.1073/pnas.2122090119.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionPrior SARS-CoV-2 infectionSARS-CoV-2PC biopsiesAcute respiratory syndrome coronavirus 2 pandemicSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemicT-cell receptor sequencingCell receptor sequencingT cell responsesCoronavirus 2 pandemicEnzyme-linked immunosorbent assayLack of associationCOVID toesSkin eruptionAntibody responseImmunohistochemistry studiesBackground seroprevalenceTissue microarrayViral infectionStimulation assaysCell responsesInfectionChilblainsImmunosorbent assayAbortive infection
Clinical Trials
Current Trials
Long Covid: Understanding Immune, Symptom, and Treatment Experiences Nationwide (LISTEN Study)
HIC ID2000032207RoleSub InvestigatorPrimary Completion Date01/31/2025Recruiting ParticipantsGenderBothAge18+ years
Clinical Care
Dr. Jeff Gehlhausen, MD, PhD, is a dermatologist at Yale Medicine in New Haven, Connecticut. He specializes in caring for patients with complex autoimmune skin conditions such as cutaneous lupus, dermatomyositis, and vasculitis.
Overview
Jeff Gehlhausen, MD, PhD, is a dermatologist specializing in complex autoimmune skin conditions such as cutaneous lupus, dermatomyositis, and vasculitis. He combines his deep understanding of the immune system with the latest treatments to help patients with challenging skin diseases that affect overall health.
Dr. Gehlhausen's research focuses on understanding the signals underlying autoimmune diseases to better diagnose, treat, and manage conditions like lupus and dermatomyositis, potentially opening avenues for new therapies. His work involves basic and translational research using patient-derived samples to study the diseases he encounters in the clinic, with the goal of uncovering new insights into the pathophysiology of autoimmune skin diseases.
As an assistant professor of dermatology at Yale School of Medicine, Dr. Gehlhausen is committed to educating the next generation of dermatologists. He actively participates in teaching and mentoring residents and medical students at Yale, sharing his knowledge and passion for dermatology and autoimmune diseases.
Dr. Gehlhausen earned his medical degree and doctorate from Indiana University. He completed an internal medicine internship at Vanderbilt University and a dermatology residency at Yale School of Medicine, where he also completed a postdoctoral research fellowship with Akiko Iwasaki, PhD, a renowned immunologist who has worked on many basic and clinical aspects of viral immunology. He further specialized in autoimmune skin disorders during advanced training at Brigham and Women's Hospital.
Clinical Specialties
Dermatology; Dermatopathology
Fact Sheets
Ringworm (Tinea)
Learn More on Yale MedicineLupus
Learn More on Yale MedicinePrurigo Nodularis
Learn More on Yale MedicineDiagnosing Lupus Nephritis
Learn More on Yale Medicine
Board Certifications
Dermatology
- Certification Organization
- AB of Dermatology
- Original Certification Date
- 2021
Yale Medicine News
News
News
Get In Touch
Contacts
Appointment Number
Administrative Support
Locations
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.