2023
Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study
Sanft T, Harrigan M, McGowan C, Cartmel B, Zupa M, Li F, Ferrucci L, Puklin L, Cao A, Nguyen T, Neuhouser M, Hershman D, Basen-Engquist K, Jones B, Knobf T, Chagpar A, Silber A, Tanasijevic A, Ligibel J, Irwin M. Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study. Journal Of Clinical Oncology 2023, 41: 5285-5295. PMID: 37656930, PMCID: PMC10691793, DOI: 10.1200/jco.23.00871.Peer-Reviewed Original ResearchConceptsRelative dose intensityPathologic complete responseProportion of patientsBreast cancerNeoadjuvant chemotherapyChemotherapy completionComplete responseNutrition interventionsHigher pathologic complete responseHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Triple-negative breast cancerChemotherapy dose adjustmentsHome-based exerciseGrowth factor receptor 2Breast cancer outcomesEffects of exerciseFactor receptor 2Electronic medical recordsChi-square testUsual careDose intensityExercise interventionDose adjustmentRandomized trials
2020
Skin carotenoids are inversely associated with adiposity in breast cancer survivors
Cartmel B, Anderson C, Irwin ML, Harrigan M, Sanft T, Li F, Gellermann W, Ermakov IV, Ferrucci LM. Skin carotenoids are inversely associated with adiposity in breast cancer survivors. Nutrition Research 2020, 79: 77-86. PMID: 32650223, PMCID: PMC7409553, DOI: 10.1016/j.nutres.2020.05.012.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsSkin carotenoid scoreUsual care groupCancer survivorsSkin carotenoidsBody fatCare groupSerum biomarkersAdiposity measuresLog C-reactive protein levelsBaseline percent body fatObese breast cancer survivorsC-reactive protein levelsDual-energy X-ray absorptiometryStrong associationBreast cancer patientsWeight loss trialStudy of overweightTotal body fatPercent body fatX-ray absorptiometryLog leptinPoor outcomeCancer patientsHip circumference
2015
Randomized Trial Comparing Telephone Versus In-Person Weight Loss Counseling on Body Composition and Circulating Biomarkers in Women Treated for Breast Cancer: The Lifestyle, Exercise, and Nutrition (LEAN) Study
Harrigan M, Cartmel B, Loftfield E, Sanft T, Chagpar AB, Zhou Y, Playdon M, Li F, Irwin ML. Randomized Trial Comparing Telephone Versus In-Person Weight Loss Counseling on Body Composition and Circulating Biomarkers in Women Treated for Breast Cancer: The Lifestyle, Exercise, and Nutrition (LEAN) Study. Journal Of Clinical Oncology 2015, 34: 669-676. PMID: 26598750, PMCID: PMC4872022, DOI: 10.1200/jco.2015.61.6375.Peer-Reviewed Original ResearchConceptsWeight loss counselingC-reactive protein levelsUsual careTelephone counselingPhysical activityBody compositionSerum biomarkersBreast cancerPerson counselingWeight loss intervention groupStage I breast cancerEffective weight loss strategyWeight lossI breast cancerBreast cancer survivorsBody mass indexBreast cancer mortalityWeight loss strategiesProtein levelsBreast cancer treatmentMean BMIUC groupMass indexCancer survivorsCancer mortality