2017
Predictive value of telomere length on outcome following acute myocardial infarction: evidence for contrasting effects of vascular vs. blood oxidative stress
Margaritis M, Sanna F, Lazaros G, Akoumianakis I, Patel S, Antonopoulos AS, Duke C, Herdman L, Psarros C, Oikonomou EK, Shirodaria C, Petrou M, Sayeed R, Krasopoulos G, Lee R, Tousoulis D, Channon KM, Antoniades C. Predictive value of telomere length on outcome following acute myocardial infarction: evidence for contrasting effects of vascular vs. blood oxidative stress. European Heart Journal 2017, 38: 3094-3104. PMID: 28444175, PMCID: PMC5837455, DOI: 10.1093/eurheartj/ehx177.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsAcute myocardial infarctionVascular smooth muscle cellsVascular oxidative stressSaphenous veinMyocardial infarctionOxidative stressPredictive valueRecent acute myocardial infarctionCoronary artery bypassBlood mononuclear cellsClinical predictive valueBlood oxidative stressSmooth muscle cellsFunctional genetic polymorphismsEffects of vascularTissue-specific biomarkersArtery bypassProspective cohortConsecutive patientsClinical outcomesVascular factorsPost-AMIMononuclear cellsArtery segments
2015
The role of microRNAs in coronary artery disease: From pathophysiology to diagnosis and treatment
Economou EK, Oikonomou E, Siasos G, Papageorgiou N, Tsalamandris S, Mourouzis K, Papaioanou S, Tousoulis D. The role of microRNAs in coronary artery disease: From pathophysiology to diagnosis and treatment. Atherosclerosis 2015, 241: 624-633. PMID: 26117399, DOI: 10.1016/j.atherosclerosis.2015.06.037.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsApoptosisAtherosclerosisBiomarkersBlood PlateletsCell MovementCoronary Artery DiseaseDisease ProgressionEndothelium, VascularGene Expression RegulationHumansLipoproteins, HDLLipoproteins, LDLMiceMicroRNAsMonocytesMuscle, Smooth, VascularMyocardial InfarctionNeovascularization, PathologicOligonucleotidesReperfusion InjuryStem CellsConceptsCoronary artery diseaseDevelopment of atherosclerosisArtery diseaseCoronary artery disease progressionPathogenesis of atherosclerosisStudy of miRNAsMyocardial infarctionDisease progressionSpecific miRNA expression patternsTherapeutic approachesRole of microRNAsPreventive opportunitiesDiagnostic biomarkersRelated conditionsAtherosclerosisMiRNA expression patternsDiseaseNon-coding RNA moleculesRole of miRNAsIntercellular communicationIntracellular regulatorsExpression patternsMiRNAsPost-transcriptional levelGene expression