2015
Management and outcomes in patients with moderate or severe functional mitral regurgitation and severe left ventricular dysfunction
Samad Z, Shaw LK, Phelan M, Ersboll M, Risum N, Al-Khalidi HR, Glower DD, Milano CA, Alexander JH, O'Connor CM, Wang A, Velazquez EJ. Management and outcomes in patients with moderate or severe functional mitral regurgitation and severe left ventricular dysfunction. European Heart Journal 2015, 36: 2733-2741. PMID: 26233850, DOI: 10.1093/eurheartj/ehv343.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseSevere mitral regurgitationEvent-free survival benefitHigher event-free survivalSevere functional mitral regurgitationMV surgerySevere LV dysfunctionEvent-free survivalOutcomes of patientsMitral regurgitationFunctional mitral regurgitationIPW adjustmentSystolic dysfunctionLV dysfunctionSurvival benefitEntire cohortTreatment strategiesSevere left ventricular systolic dysfunctionCoronary artery bypass graft surgeryMultivariable Cox proportional hazards modelsSevere left ventricular dysfunctionArtery bypass graft surgeryLeft ventricular systolic dysfunctionCox proportional hazards modelIsolated MV surgery
2013
Inducible Myocardial Ischemia and Outcomes in Patients With Coronary Artery Disease and Left Ventricular Dysfunction
Panza JA, Holly TA, Asch FM, She L, Pellikka PA, Velazquez EJ, Lee KL, Borges-Neto S, Farsky PS, Jones RH, Berman DS, Bonow RO. Inducible Myocardial Ischemia and Outcomes in Patients With Coronary Artery Disease and Left Ventricular Dysfunction. Journal Of The American College Of Cardiology 2013, 61: 1860-1870. PMID: 23500234, PMCID: PMC3755503, DOI: 10.1016/j.jacc.2013.02.014.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseDobutamine stress echocardiogramLV ejection fractionInducible myocardial ischemiaEjection fractionMedical therapyMyocardial ischemiaCause mortalityVentricular dysfunctionArtery diseaseClinical endpointsMultivessel coronary artery diseaseOptimal medical therapyRadionuclide stress testsCoronary artery bypassSevere LV dysfunctionLeft ventricular dysfunctionStress-induced ischemiaPrevious myocardial infarctionSummed difference scoreStress testingRNS testingSTICH patientsSTICH trialArtery bypass
2009
Use of phase analysis of gated SPECT perfusion imaging to quantify dyssynchrony in patients with mild-to-moderate left ventricular dysfunction
Atchley AE, Trimble MA, Samad Z, Shaw LK, Pagnanelli R, Chen J, Garcia EV, Iskandrian AE, Velazquez EJ, Borges-Neto S. Use of phase analysis of gated SPECT perfusion imaging to quantify dyssynchrony in patients with mild-to-moderate left ventricular dysfunction. Journal Of Nuclear Cardiology 2009, 16: 888-894. PMID: 19690935, PMCID: PMC3048054, DOI: 10.1007/s12350-009-9136-3.Peer-Reviewed Original ResearchConceptsModerate LV dysfunctionSevere LV dysfunctionLV dysfunctionMechanical dyssynchronyQRS durationNormal controlsGated SPECTModerate left ventricular dysfunctionNYHA class IIIPrevalence of dyssynchronyLeft ventricular dysfunctionCohort of patientsMajority of patientsLV mechanical dyssynchronyGated SPECT imagingCurrent selection criteriaLess dyssynchronyLVEF 35More dyssynchronyVentricular dysfunctionPatient selectionDyssynchronyPatientsSPECT perfusionDysfunction
2008
Emerging Role of Myocardial Perfusion Imaging to Evaluate Patients for Cardiac Resynchronization Therapy††Conflicts of interest: Dr. Garcia has an ownership interest in and serves as a consultant and advisory board member for Syntermed, Inc., Atlanta, Georgia. Dr. Garcia also receives royalties from the sale of clinical software that was used as part of this research. Dr. Borges-Neto and Dr. Trimble have received research support from the Duke-Medtronic Strategic Alliance, which funded some of the studies reviewed in this report.
Trimble MA, Borges-Neto S, Velazquez EJ, Chen J, Shaw LK, Pagnanelli R, Garcia EV, Iskandrian AE. Emerging Role of Myocardial Perfusion Imaging to Evaluate Patients for Cardiac Resynchronization Therapy††Conflicts of interest: Dr. Garcia has an ownership interest in and serves as a consultant and advisory board member for Syntermed, Inc., Atlanta, Georgia. Dr. Garcia also receives royalties from the sale of clinical software that was used as part of this research. Dr. Borges-Neto and Dr. Trimble have received research support from the Duke-Medtronic Strategic Alliance, which funded some of the studies reviewed in this report. The American Journal Of Cardiology 2008, 102: 211-217. PMID: 18602524, DOI: 10.1016/j.amjcard.2008.03.043.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyMechanical dyssynchronyElectrical dyssynchronyMyocardial perfusionSignificant heart failure symptomsTomographic myocardial perfusion imagingLV functional improvementHeart failure symptomsLV systolic dysfunctionSevere LV dysfunctionSelection of patientsManagement of patientsLV mechanical dyssynchronyLeft ventricular dyssynchronyMyocardial perfusion imagingCurrent selection criteriaLV dysfunctionSystolic dysfunctionEchocardiographic measuresResynchronization therapyVentricular dyssynchronyCardiac resynchronizationClinical statusLV remodelingFailure symptoms