2024
Venetoclax-Based Therapy Versus Intensive Chemotherapy Followed By Allogeneic-Stem Cell Transplantation for High-Risk Elderly Acute Myeloid Leukemia
Iat A, Bewersdorf J, Gilhodes J, Liu Y, Shallis R, Boussi L, Zucenka A, Bystrom R, DeAngelo D, Berton G, Soua A, Ling K, Aguirre L, Stone R, Luskin M, Garcia J, Winer E, Chen E, Wadleigh M, Goldberg A, Zeidan A, Cluzeau T, Shimony S, Stahl M, Garciaz S. Venetoclax-Based Therapy Versus Intensive Chemotherapy Followed By Allogeneic-Stem Cell Transplantation for High-Risk Elderly Acute Myeloid Leukemia. Blood 2024, 144: 1508. DOI: 10.1182/blood-2024-207045.Peer-Reviewed Original ResearchCumulative incidence of relapseRelapse-free survivalAcute myeloid leukemiaOverall response rateAdverse risk cytogeneticsAllo-SCTVEN-based therapyNon-relapse mortalityIntensive chemotherapyComposite CROverall survivalIC groupMedian OSMyeloid leukemiaElderly patientsTherapy-related acute myeloid leukemiaHigh-risk acute myeloid leukemiaAllogeneic stem-cell transplantationMedian time to relapseElderly acute myeloid leukemiaLong-term disease controlResponse rateFrequent cytogenetic alterationsProspective validation trialVIALE-A trial
2017
Immunotherapeutic Concepts to Target Acute Myeloid Leukemia: Focusing on the Role of Monoclonal Antibodies, Hypomethylating Agents and the Leukemic Microenvironment
Gbolahan OB, Zeidan AM, Stahl M, Abu Zaid M, Farag S, Paczesny S, Konig H. Immunotherapeutic Concepts to Target Acute Myeloid Leukemia: Focusing on the Role of Monoclonal Antibodies, Hypomethylating Agents and the Leukemic Microenvironment. International Journal Of Molecular Sciences 2017, 18: 1660. PMID: 28758974, PMCID: PMC5578050, DOI: 10.3390/ijms18081660.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsLeukemic microenvironmentAllogeneic stem cell transplantationLong-term disease controlAcute myeloid leukemia (AML) treatmentMonoclonal antibodiesIntensive chemotherapeutic protocolsImmune-based therapiesMajority of patientsOverall survival rateStem cell transplantationManagement of AMLAcute myeloid leukemiaElicit immune responsesMyeloid leukemia treatmentEarly phase studiesNovel treatment conceptsImmunotherapeutic interventionsMost patientsAML therapyImmunotherapeutic conceptsPoor outcomeCell transplantationToxic therapiesChemotherapeutic protocolsMyeloid leukemia