2024
Thirty-Day Outcomes from the Disrupt PAD BTK II Study of the Shockwave Intravascular Lithotripsy System for Treatment of Calcified Below-the-Knee Peripheral Arterial Disease
Chandra V, Lansky A, Sayfo S, Shammas N, Soukas P, Park J, Siah M, Babaev A, Shields R, West N, Armstrong E. Thirty-Day Outcomes from the Disrupt PAD BTK II Study of the Shockwave Intravascular Lithotripsy System for Treatment of Calcified Below-the-Knee Peripheral Arterial Disease. Journal Of Vascular Surgery 2024 PMID: 39536842, DOI: 10.1016/j.jvs.2024.11.003.Peer-Reviewed Original ResearchPost-operative deathsII studyPercutaneous transluminal angioplastyProcedural successBTK lesionsResidual stenosisFollow-upIntravascular lithotripsyIndex limbCore labRutherford category 3Treated target lesionsUltrasound core laboratoryInterventional clinical studyAngiographic core labThirty-day outcomesMinimal adverse eventsTarget lesion lengthSevere lesion calcificationIVL systemAdverse limb eventsOptimal standard of careStandard of carePeripheral arterial diseaseVascuQol scores
2022
Geographic Variations on the Safety and Efficacy of the Supreme Biodegradable Polymer DES: Results From PIONEER III
Garot P, Leon M, Saito S, Baumbach A, Kereiakes D, Windecker S, Pietras C, Dressler O, Issever M, Curtis M, Bertolet B, Zidar J, Smits P, Diaz V, McLaurin B, Cequier A, Hofma S, Dib N, Namiki A, Takahashi A, Kakuta T, Hirohata A, Lansky A. Geographic Variations on the Safety and Efficacy of the Supreme Biodegradable Polymer DES: Results From PIONEER III. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 2: 100515. PMID: 39132534, PMCID: PMC11308104, DOI: 10.1016/j.jscai.2022.100515.Peer-Reviewed Original ResearchDrug-eluting stentsDurable polymer everolimus-eluting stentsEverolimus-eluting stentsIII trialsLesion failureClinical outcomesMyocardial infarctionMajor adverse cardiac eventsVessel-related myocardial infarctionBiodegradable polymer drug-eluting stentsAdverse cardiac eventsOutcomes of patientsTarget lesion failureTarget lesion revascularizationLesion revascularizationCardiac eventsPatient characteristicsCardiac deathDES groupProcedural successStent thrombosisSubgroup analysisPatient outcomesNonsignificant trendEnrollment location
2021
Safety and efficacy of dedicated guidewire, microcatheter, and guide catheter extension technologies for chronic total coronary occlusion revascularization: Primary results of the Teleflex Chronic Total Occlusion Study
Kandzari DE, Alaswad K, Jaffer FA, Brilakis E, Croce K, Kearney K, Spaedy A, Yeh R, Thompson C, Nicholson W, Wyman RM, Riley R, Lansky A, Buller C, Karmpaliotis D. Safety and efficacy of dedicated guidewire, microcatheter, and guide catheter extension technologies for chronic total coronary occlusion revascularization: Primary results of the Teleflex Chronic Total Occlusion Study. Catheterization And Cardiovascular Interventions 2021, 99: 263-270. PMID: 34582080, DOI: 10.1002/ccd.29962.Peer-Reviewed Original ResearchConceptsMyocardial infarctionGuidewire recanalizationProcedural successCatheter extensionChronic total coronary occlusion revascularizationChronic total occlusion (CTO) percutaneous revascularizationFavorable procedural successGuide catheter extensionHigher lesion complexityHospital cardiac deathProspective registration studyTotal Occlusion StudyTarget lesion revascularizationPrevalence of diabetesPrior myocardial infarctionSingle-arm studyTIMI grade 2Femoral arterial accessJ-CTO scorePrevious bypass surgeryNon-CTO PCIHospital MACELesion revascularizationCTO revascularizationHemodynamic instability
2018
A prospective, multi‐center study of the chocolate balloon in femoropopliteal peripheral artery disease: The Chocolate BAR registry
Mustapha JA, Lansky A, Shishehbor M, McClure J, Johnson S, Davis T, Makam P, Crowder W, Konstantino E, Attaran RR, Investigators T. A prospective, multi‐center study of the chocolate balloon in femoropopliteal peripheral artery disease: The Chocolate BAR registry. Catheterization And Cardiovascular Interventions 2018, 91: 1144-1148. PMID: 29513389, DOI: 10.1002/ccd.27565.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, BalloonEquipment DesignFemaleFemoral ArteryHumansMaleMiddle AgedPeripheral Arterial DiseasePopliteal ArteryProduct Surveillance, PostmarketingProspective StudiesRegistriesRisk FactorsStentsTime FactorsTreatment OutcomeUnited StatesVascular Access DevicesVascular PatencyConceptsTarget lesion revascularizationPrimary endpointFemoropopliteal peripheral artery diseaseSymptomatic peripheral arterial diseaseExcellent procedural outcomesLower dissection ratePeripheral arterial diseasePeripheral artery diseaseAcute procedural successLong-term outcomesPost-market registryMulti-center studyAngioplasty balloon catheterPercutaneous transluminal angioplasty balloon catheterRutherford classCause mortalityLesion revascularizationMajor amputationArtery diseaseArterial diseaseProcedural successUnplanned amputationBalloon catheterProcedural outcomesProcedure success
2004
Magnitude and impact of treatment delays on weeknights and weekends in patients undergoing primary angioplasty for acute myocardial infarction (the cadillac trial)
Sadeghi HM, Grines CL, Chandra HR, Mehran R, Fahy M, Cox DA, Garcia E, Tcheng JE, Griffin JJ, Stuckey TD, Lansky AJ, O'Neill WW, Stone GW. Magnitude and impact of treatment delays on weeknights and weekends in patients undergoing primary angioplasty for acute myocardial infarction (the cadillac trial). The American Journal Of Cardiology 2004, 94: 637-640. PMID: 15342297, DOI: 10.1016/j.amjcard.2004.05.030.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAcute myocardial infarctionMyocardial infarctionOutcomes of patientsCADILLAC trialPrimary angioplastyCoronary interventionProcedural successTreatment delayMyocardial recoveryPatientsModest delayInfarctionWeeknightsHoursTreatment timeAngioplastyWeekendsTrialsFavorable effect of γ‐radiation for in‐stent restenosis: Effect of diabetes on angiographic and clinical outcomes
Iakovou I, Mehran R, Dangas G, Lansky AJ, Stone GW, Mintz GS, Aymong E, Ashby DT, Pichard AD, Satler LF, Kent K, Leon MB, Waksman R. Favorable effect of γ‐radiation for in‐stent restenosis: Effect of diabetes on angiographic and clinical outcomes. Catheterization And Cardiovascular Interventions 2004, 62: 303-307. PMID: 15224295, DOI: 10.1002/ccd.20070.Peer-Reviewed Original ResearchConceptsTarget lesion revascularizationDiabetes mellitusStent restenosisMajor adverse cardiac event ratesAdverse cardiac event ratesIn-Stent Restenosis TrialLower target lesion revascularizationMajor adverse cardiac eventsNon-DM patientsAdverse cardiac eventsCardiac event rateTreatment of ISREffect of diabetesSimilar procedural successGamma radiation therapyLesion revascularizationHospital outcomesRestenosis TrialVessel revascularizationCardiac eventsProcedural successClinical outcomesWashington RadiationVascular brachytherapyPatientsShort- and long-term results after multivessel stenting in diabetic patients
Moses J, Mehran R, Dangas G, Kobayashi Y, Lansky A, Mintz G, Aymong E, Fahy M, Stone GW, Leon MB. Short- and long-term results after multivessel stenting in diabetic patients. Journal Of The American College Of Cardiology 2004, 43: 1348-1354. PMID: 15093865, DOI: 10.1016/j.jacc.2003.04.004.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryNon-diabetic patientsHospital coronary artery bypass graft surgeryOne-year survivalDiabetic patientsMultivessel stentingOral agentsRevascularization ratesClinical outcomesProcedural successMyocardial infarctionTarget lesion revascularization rateArtery bypass graft surgeryHigh technical success rateDiabetes mellitus statusExcellent procedural successHospital cardiac deathSubsequent revascularization ratesBypass graft surgeryLesion revascularization rateNative coronary lesionsOne-year mortalityTechnical success rateConventional balloon angioplastyAcceptable clinical outcomesImpact of Symptomatic Peripheral Arterial Disease on 1-Year Mortality in Patients Undergoing Percutaneous Coronary Interventions
Nikolsky E, Mehran R, Mintz GS, Dangas GD, Lansky AJ, Aymong ED, Negoita M, Fahy M, Moussa I, Roubin GS, Moses JW, Stone GW, Leon MB. Impact of Symptomatic Peripheral Arterial Disease on 1-Year Mortality in Patients Undergoing Percutaneous Coronary Interventions. Journal Of Endovascular Therapy 2004, 11: 60-70. PMID: 14748627, DOI: 10.1177/152660280401100108.Peer-Reviewed Original ResearchConceptsSymptomatic peripheral arterial diseasePeripheral arterial diseasePercutaneous coronary interventionCoronary interventionArterial diseaseProcedural successTarget lesionsPresence of PADUrgent coronary artery bypassSmaller body surface areaMore target lesionsAtherosclerotic risk factorsChronic renal insufficiencyCoronary artery bypassFifth of patientsTransient ischemic attackHigh rateBody surface areaHigh mortality rateLower ratesFemoral hematomaHospital complicationsIschemic attackRe-PCIArtery bypassImpact of Symptomatic Peripheral Arterial Disease on 1-Year Mortality in Patients Undergoing Percutaneous Coronary Interventions
Nikolsky E, Mehran R, Mintz G, Dangas G, Lansky A, Aymong E, Negoita M, Fahy M, Moussa I, Roubin G, Moses J, Stone G, Leon M. Impact of Symptomatic Peripheral Arterial Disease on 1-Year Mortality in Patients Undergoing Percutaneous Coronary Interventions. Journal Of Endovascular Therapy 2004, 11: 60-70. DOI: 10.1583/1545-1550(2004)011<0060:iospad>2.0.co;2.Peer-Reviewed Original ResearchSymptomatic peripheral arterial diseasePeripheral arterial diseasePercutaneous coronary interventionCoronary interventionArterial diseaseProcedural successTarget lesionsPresence of PADUrgent coronary artery bypassSmaller body surface areaMore target lesionsAtherosclerotic risk factorsChronic renal insufficiencyCoronary artery bypassFifth of patientsTransient ischemic attackHigh rateBody surface areaHigh mortality rateLower ratesFemoral hematomaHospital complicationsIschemic attackRe-PCIArtery bypass
2003
Safety of an Aspirin-Alone Regimen After Intracoronary Stenting With a Heparin-Coated Stent
Mehran R, Aymong ED, Ashby DT, Fischell T, Whitworth H, Siegel R, Thomas W, Wong SC, Narasimaiah R, Lansky AJ, Leon MB. Safety of an Aspirin-Alone Regimen After Intracoronary Stenting With a Heparin-Coated Stent. Circulation 2003, 108: 1078-1083. PMID: 12925457, DOI: 10.1161/01.cir.0000086347.31341.f9.Peer-Reviewed Original ResearchConceptsStent thrombosisIntracoronary stentingNon-Q-wave myocardial infarctionMajor adverse cardiac eventsNative coronary artery lesionsAdverse cardiac eventsBlunt chest traumaPrimary end pointCoronary artery lesionsNative coronary arteriesDevastating clinical consequencesBalloon-expandable stentsAspirin monotherapyAnticoagulation therapyArtery lesionsCardiac eventsChest traumaInfrequent complicationSelect patientsProcedural successRestenotic lesionsCoronary arteryOptimal stentingMyocardial infarctionClinical consequences
2002
Long-Term Outcome of Patients Treated With Repeat Percutaneous Coronary Intervention After Failure of γ-Brachytherapy for the Treatment of In-Stent Restenosis
Prpic R, Teirstein PS, Reilly JP, Moses JW, Tripuraneni P, Lansky AJ, Giorgianni JA, Jani S, Wong SC, Fish RD, Ellis S, Holmes DR, Kereiakas D, Kuntz RE, Leon MB. Long-Term Outcome of Patients Treated With Repeat Percutaneous Coronary Intervention After Failure of γ-Brachytherapy for the Treatment of In-Stent Restenosis. Circulation 2002, 106: 2340-2345. PMID: 12403664, DOI: 10.1161/01.cir.0000036366.62288.74.Peer-Reviewed Original ResearchConceptsTarget lesion revascularizationIndex treatmentIntracoronary brachytherapyPercutaneous interventionStent restenosisAcceptable long-term resultsMajor adverse event rateRepeat percutaneous coronary interventionRepeat target vessel revascularizationSubsequent target lesion revascularizationTarget vessel revascularizationAcute procedural successAdverse event ratesPercutaneous coronary interventionIntracoronary radiation therapyLong-term outcomesLong-term resultsIn-Stent RestenosisLesion revascularizationPlacebo groupCoronary interventionFailure patientsProcedural successAngioplasty/Term outcomesComparison of clinical outcomes using stents versus no stents after percutaneous coronary intervention for proximal left anterior descending versus proximal right and left circumflex coronary arteries
Ashby DT, Dangas G, Mehran R, Lansky AJ, Narasimaiah R, Iakovou I, Polena S, Satler LF, Pichard AD, Kent KM, Stone GW, Leon MB. Comparison of clinical outcomes using stents versus no stents after percutaneous coronary intervention for proximal left anterior descending versus proximal right and left circumflex coronary arteries. The American Journal Of Cardiology 2002, 89: 1162-1166. PMID: 12008168, DOI: 10.1016/s0002-9149(02)02297-x.Peer-Reviewed Original ResearchMeSH KeywordsAgedArteriesBlood Vessel Prosthesis ImplantationCohort StudiesCoronary Artery DiseaseCoronary RestenosisCoronary VesselsDistrict of ColumbiaFemaleFollow-Up StudiesHumansMaleMiddle AgedPostoperative ComplicationsRadiographyStentsStroke VolumeSurvival AnalysisTime FactorsTreatment OutcomeConceptsPercutaneous coronary interventionTarget lesion revascularizationProximal LAD arteryProximal rightClinical restenosisCoronary interventionCircumflex arteryProcedural successLAD arteryProximal coronary artery stenosisSingle-vessel coronary diseaseAnterior descending (LAD) stenosisHigh rateCircumflex coronary arteryLower procedural successCoronary artery stenosisSignificant differencesDifferent lesion locationsCoronary artery stentsLesion revascularizationProximal LADCoronary diseaseArtery stenosisClinical outcomesHospital eventsUse of localised intracoronary β radiation in treatment of in-stent restenosis: the INHIBIT randomised controlled trial
Waksman R, Raizner AE, Yeung AC, Lansky AJ, Vandertie L, investigators I. Use of localised intracoronary β radiation in treatment of in-stent restenosis: the INHIBIT randomised controlled trial. The Lancet 2002, 359: 551-557. PMID: 11867107, DOI: 10.1016/s0140-6736(02)07741-3.Peer-Reviewed Original ResearchConceptsBinary angiographic restenosis ratePrimary safety endpointAngiographic restenosis rateTarget lesion revascularisationStent restenosisPlacebo groupSafety endpointRestenosis rateRadiated groupMyocardial infarctionMajor adverse cardiac eventsIntracoronary beta radiationIntracoronary β-radiationSuccessful coronary interventionAdverse cardiac eventsPrimary efficacy endpointRecurrence of restenosisBeta-radiation treatmentEfficacy endpointAngiographic outcomesCardiac eventsCoronary interventionIntracoronary stentingProcedural successVascular brachytherapy
2001
Clinical outcomes of compromised side branch (stent jail) after coronary stenting with the NIR stent
Bhargava B, Waksman R, Lansky A, Kornowski R, Mehran R, Leon M. Clinical outcomes of compromised side branch (stent jail) after coronary stenting with the NIR stent. Catheterization And Cardiovascular Interventions 2001, 54: 295-300. PMID: 11747152, DOI: 10.1002/ccd.1287.Peer-Reviewed Original ResearchConceptsMyocardial infarctionSB occlusionSide branch compromiseCoronary stentingClinical outcomesStent implantationNon-Q-wave myocardial infarctionLate major adverse eventsLong-term clinical outcomesSB compromiseLate target lesion revascularizationHospital ischemic complicationsMore myocardial infarctionsNIR stent implantationMajor adverse eventsTarget lesion revascularizationSide branch occlusionSB patencyBaseline patientIschemic complicationsLesion revascularizationRepeat revascularizationAdverse eventsConsecutive patientsProcedural successAre we making progress with percutaneous saphenous vein graft treatment? A comparison of 1990 to 1994 and 1995 to 1998 results
Hong M, Mehran R, Dangas G, Mintz G, Lansky A, Kent K, Pichard A, Satler L, Stone G, Leon M. Are we making progress with percutaneous saphenous vein graft treatment? A comparison of 1990 to 1994 and 1995 to 1998 results. Journal Of The American College Of Cardiology 2001, 38: 150-154. PMID: 11451265, DOI: 10.1016/s0735-1097(01)01324-9.Peer-Reviewed Original ResearchConceptsLate cardiac eventsSVG lesionsCardiac eventsDistal embolizationStent useSaphenous vein graft angioplastyUnfavorable lesion characteristicsVein graft angioplastyOne-year outcomesProcedural success rateHigh procedural successHigh-risk lesionsGraft angioplastySVG angioplastyLate mortalityRepeat revascularizationBaseline characteristicsProcedural successRisk lesionsFavorable outcomeLesion characteristicsGraft treatmentMultivariate analysisAngioplastyLesionsEffectiveness of excimer laser coronary angioplasty in acute myocardial infarction or in unstable angina pectoris
Topaz O, Bernardo N, Shah R, McQueen R, Desai P, Janin Y, Lansky A, Carr M. Effectiveness of excimer laser coronary angioplasty in acute myocardial infarction or in unstable angina pectoris. The American Journal Of Cardiology 2001, 87: 849-855. PMID: 11274939, DOI: 10.1016/s0002-9149(00)01525-3.Peer-Reviewed Original ResearchConceptsExcimer laser coronary angioplastyUnstable angina pectorisAcute myocardial infarctionPercutaneous excimer laser coronary angioplastyAcute coronary syndromeUAP groupLaser coronary angioplastyAMI groupLaser successCoronary syndromeAngina pectorisCoronary angioplastyProcedural successMyocardial infarctionGlycoprotein IIb/IIIa receptor antagonistsIIb/IIIa receptor antagonistsAdjunct balloon dilationMyocardial infarction (TIMI) flowEmergency bypass surgeryIndependent core laboratoryMinimal luminal diameterCreatine kinase levelsFinal stenosisBurden areasBypass surgeryIntracoronary radiation with gamma wire inhibits recurrent in-stent restenosis
Waksman R, Bhargava B, Chan R, Sherman W, Pisch J, Mintz G, Lansky A, Ahmed J, Ricci N, Liprie S. Intracoronary radiation with gamma wire inhibits recurrent in-stent restenosis. Cardiovascular Revascularization Medicine 2001, 2: 63-68. PMID: 11340009, DOI: 10.1016/s1522-1865(00)00086-x.Peer-Reviewed Original ResearchConceptsIntracoronary gamma radiationTarget lesion revascularizationStent restenosisMyocardial infractionBaseline lesion lengthUnderwent bypass surgeryBinary restenosis rateEvent-free survivalNeointimal tissue proliferationInitial clinical trialsStent restenosis resultsSource wireLesion revascularizationRepeat PTCAAngiographic restenosisPrimary endpointRepeat revascularizationSecondary endpointsBypass surgeryRestenosis rateIntracoronary radiationProcedural successTherapeutic challengeClinical trialsNeointimal hyperplasiaInfluence of gender on early and one-year clinical outcomes after saphenous vein graft stenting
Ahmed J, Dangas G, Lansky A, Mehran R, Hong M, Mintz G, Pichard A, Satler L, Kent K, Stone G, Leon M. Influence of gender on early and one-year clinical outcomes after saphenous vein graft stenting. The American Journal Of Cardiology 2001, 87: 401-405. PMID: 11179522, DOI: 10.1016/s0002-9149(00)01391-6.Peer-Reviewed Original ResearchConceptsAcute renal failureClinical outcomesSVG lesionsHospital mortalityVascular complicationsRenal failureProcedural successStent implantationFemale genderOne-year clinical outcomesSaphenous vein graft stentingLate clinical outcomesOverall procedural successSaphenous vein graftsVentricular ejection fractionInfluence of genderMultivariate regression analysisGraft stentingLesion revascularizationCoronary revascularizationConsecutive patientsDiabetes mellitusEjection fractionHospital eventsVein graftsClinical and angiographic outcome in the laser angioplasty for restenotic stents (LARS) multicenter registry
Giri S, Ito S, Lansky A, Mehran R, Margolis J, Gilmore P, Garratt K, Cummins F, Moses J, Rentrop P, Oesterle S, Power J, Kent K, Satler L, Pichard A, Wu H, Greenberg A, Bucher T, Kerker W, Abizaid A, Saucedo J, Leon M, Popma J. Clinical and angiographic outcome in the laser angioplasty for restenotic stents (LARS) multicenter registry. Catheterization And Cardiovascular Interventions 2001, 52: 24-34. PMID: 11146517, DOI: 10.1002/1522-726x(200101)52:1<24::aid-ccd1007>3.0.co;2-y.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryAngioplasty, LaserChi-Square DistributionCoronary AngiographyCoronary DiseaseFemaleFollow-Up StudiesGraft Occlusion, VascularHumansMaleMiddle AgedMulticenter Studies as TopicProbabilityRandomized Controlled Trials as TopicRecurrenceRegistriesStentsSurvival RateTreatment OutcomeConceptsMulticenter case-control studyCase-control studyAngiographic recurrence rateUnstable anginaCoronary angioplastyAntegrade flowClinical outcomesProcedural successBalloon angioplastyRecurrence rateLate outcomesStent restenosisControl studyPatientsConsecutive proceduresNeointimal tissuePTCASuch treatmentAngioplastySimilar ratesOutcomesAnginaRestenosisLesionsISR
2000
Intracoronary γ-Radiation Therapy After Angioplasty Inhibits Recurrence in Patients With In-Stent Restenosis
Waksman R, White R, Chan R, Bass B, Geirlach L, Mintz G, Satler L, Mehran R, Serruys P, Lansky A, Fitzgerald P, Bhargava B, Kent K, Pichard A, Leon M. Intracoronary γ-Radiation Therapy After Angioplasty Inhibits Recurrence in Patients With In-Stent Restenosis. Circulation 2000, 101: 2165-2171. PMID: 10801757, DOI: 10.1161/01.cir.101.18.2165.Peer-Reviewed Original ResearchConceptsStent restenosisIntracoronary gamma radiation therapyLess target lesion revascularizationBinary angiographic restenosisSuccessful coronary interventionTarget lesion revascularizationMajor cardiac eventsIndependent core laboratoryIntracoronary stent implantationInitial clinical trialsGamma radiation therapyLesion revascularizationAngiographic restenosisVessel revascularizationAngiographic outcomesCardiac eventsClinical restenosisCoronary interventionAdjunct therapyProcedural successStent implantationClinical trialsTreatment protocolNeointimal formationRadiation group