2021
Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: a systematic review and meta-analysis
Navarese EP, Lansky AJ, Kereiakes DJ, Kubica J, Gurbel PA, Gorog DA, Valgimigli M, Curzen N, Kandzari DE, Bonaca MP, Brouwer M, Umińska J, Jaguszewski MJ, Raggi P, Waksman R, Leon MB, Wijns W, Andreotti F. Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: a systematic review and meta-analysis. European Heart Journal 2021, 42: 4638-4651. PMID: 34002203, PMCID: PMC8669551, DOI: 10.1093/eurheartj/ehab246.Peer-Reviewed Original ResearchConceptsSpontaneous myocardial infarctionStable coronary artery disease patientsCoronary artery disease patientsElective coronary revascularisationMedical therapyCardiac mortalityMyocardial infarctionCoronary revascularisationCause mortalityDisease patientsPre-specified primary endpointCoronary artery diseaseRate ratioDeath risk reductionRandom-effects modelMultivessel diseaseMortality findingsPrimary endpointSecondary endpointsStable patientsStroke riskSurvival benefitArtery diseaseCardiac deathRevascularisation
2013
Prognostic Utility of the SYNTAX Score in Patients With Single Versus Multivessel Disease Undergoing Percutaneous Coronary Intervention (from the Acute Catheterization and Urgent Intervention Triage StrategY [ACUITY] Trial)
Caixeta A, Généreux P, Palmerini T, Lansky AJ, Mehran R, Dangas GD, Xu K, Brener SJ, Stone GW. Prognostic Utility of the SYNTAX Score in Patients With Single Versus Multivessel Disease Undergoing Percutaneous Coronary Intervention (from the Acute Catheterization and Urgent Intervention Triage StrategY [ACUITY] Trial). The American Journal Of Cardiology 2013, 113: 203-210. PMID: 24176063, DOI: 10.1016/j.amjcard.2013.08.035.Peer-Reviewed Original ResearchConceptsMultivessel coronary artery diseaseMajor adverse cardiac eventsSingle-vessel diseasePercutaneous coronary interventionSurgery scoreCoronary interventionClinical outcomesMyocardial infarctionRate of MACETaxus drug-eluting stentsCardiac Surgery (SYNTAX) scoreOverall study cohortAdverse cardiac eventsCoronary artery diseaseDrug-eluting stentsACUITY trialMultivessel diseaseSS tertilesAngiographic predictorsSYNTAX scoreCardiac eventsThird tertileArtery diseaseCardiac deathIndependent predictors
2011
Prognostic Impact of Staged Versus “One-Time” Multivessel Percutaneous Intervention in Acute Myocardial Infarction Analysis From the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trial
Kornowski R, Mehran R, Dangas G, Nikolsky E, Assali A, Claessen BE, Gersh BJ, Wong SC, Witzenbichler B, Guagliumi G, Dudek D, Fahy M, Lansky AJ, Stone GW, Investigators H. Prognostic Impact of Staged Versus “One-Time” Multivessel Percutaneous Intervention in Acute Myocardial Infarction Analysis From the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trial. Journal Of The American College Of Cardiology 2011, 58: 704-711. PMID: 21816305, DOI: 10.1016/j.jacc.2011.02.071.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionST-segment elevation myocardial infarctionMultivessel primary percutaneous coronary interventionMajor adverse cardiovascular eventsHORIZONS-AMI trialAdverse cardiovascular eventsMultivessel diseaseNonculprit lesionsCardiovascular eventsStent thrombosisPCI strategyPrimary PCIAcute Myocardial Infarction AnalysisProbable stent thrombosisTarget vessel revascularizationElevation myocardial infarctionPercutaneous coronary interventionSubgroup of patientsPrimary PCI proceduresMultivessel percutaneous interventionNonculprit vesselsCardiac mortalityCause mortalityCulprit lesionSTEMI patients
2010
Comparison of Everolimus-Eluting and Paclitaxel-Eluting Coronary Stents in Patients Undergoing Multilesion and Multivessel Intervention The SPIRIT III (A Clinical Evaluation of the Investigational Device XIENCE V Everolimus Eluting Coronary Stent System [EECSS] in the Treatment of Subjects With De Novo Native Coronary Artery Lesions) and SPIRIT IV (Clinical Evaluation of the XIENCE V Everolimus Eluting Coronary Stent System in the Treatment of Subjects With De Novo Native Coronary Artery Lesions) Randomized Trials
Kereiakes DJ, Sudhir K, Hermiller JB, Gordon PC, Ferguson J, Yaqub M, Sood P, Su X, Yakubov S, Lansky AJ, Stone GW. Comparison of Everolimus-Eluting and Paclitaxel-Eluting Coronary Stents in Patients Undergoing Multilesion and Multivessel Intervention The SPIRIT III (A Clinical Evaluation of the Investigational Device XIENCE V Everolimus Eluting Coronary Stent System [EECSS] in the Treatment of Subjects With De Novo Native Coronary Artery Lesions) and SPIRIT IV (Clinical Evaluation of the XIENCE V Everolimus Eluting Coronary Stent System in the Treatment of Subjects With De Novo Native Coronary Artery Lesions) Randomized Trials. JACC Cardiovascular Interventions 2010, 3: 1229-1239. PMID: 21232716, DOI: 10.1016/j.jcin.2010.09.014.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryAntineoplastic Agents, PhytogenicCoronary Artery BypassCoronary Artery DiseaseDrug-Eluting StentsEverolimusFemaleHumansImmunosuppressive AgentsKaplan-Meier EstimateMaleMiddle AgedPaclitaxelRandomized Controlled Trials as TopicSirolimusTime FactorsUnited StatesConceptsPaclitaxel-eluting stentsIschemia-driven target lesion revascularizationTarget vessel myocardial infarctionSPIRIT IV trialTarget lesion revascularizationVessel myocardial infarctionLesion revascularizationMultivessel diseaseMultivessel interventionAbsolute benefitMyocardial infarctionOptimal revascularization strategySingle-vessel interventionDe novo lesionsReference vessel diameterEverolimus-ElutingMultilesion interventionEfficacy outcomesNovo lesionsRevascularization strategyCoronary diseaseClinical outcomesCoronary arteryClinical safetySingle lesionSurgical Versus Percutaneous Revascularization for Multivessel Disease in Patients With Acute Coronary Syndromes Analysis From the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) Trial
Ben-Gal Y, Moses JW, Mehran R, Lansky AJ, Weisz G, Nikolsky E, Argenziano M, Williams MR, Colombo A, Aylward PE, Stone GW. Surgical Versus Percutaneous Revascularization for Multivessel Disease in Patients With Acute Coronary Syndromes Analysis From the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) Trial. JACC Cardiovascular Interventions 2010, 3: 1059-1067. PMID: 20965465, DOI: 10.1016/j.jcin.2010.06.017.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAcute Kidney InjuryAgedAngioplasty, Balloon, CoronaryBlood TransfusionCoronary AngiographyCoronary Artery BypassFemaleHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPropensity ScoreRecurrenceRisk AssessmentRisk FactorsStrokeTime FactorsTreatment OutcomeConceptsPercutaneous coronary interventionAcute coronary syndromeHigh-risk patientsMultivessel diseaseACUITY trialRenal injuryMyocardial infarctionHigh-risk acute coronary syndromesAcute Coronary Syndromes AnalysisHigh-risk ACS patientsMultivessel coronary artery diseasePeri-procedural strokePreferred revascularization strategyPropensity-matched comparisonPropensity-matched patientsAcute renal injuryCoronary artery bypassOutcomes of patientsMore blood transfusionsCoronary artery diseaseRepeat revascularization proceduresACS patientsMajor bleedingPCI groupUnplanned revascularization
2009
Treatment of left main and multivessel disease in the drug-eluting stent era.
Ng VG, Lansky AJ. Treatment of left main and multivessel disease in the drug-eluting stent era. Reviews In Cardiovascular Medicine 2009, 10 Suppl 2: s24-33. PMID: 19898278, DOI: 10.3909/ricm10s20004.Peer-Reviewed Original ResearchConceptsDrug-eluting stentsBypass surgeryMultivessel coronary artery diseaseCoronary artery bypass surgeryDrug-eluting stent eraArtery bypass surgeryHigh-risk patientsPercutaneous coronary interventionCoronary artery diseaseSignificant survival advantageAlternative treatment modalityStandard of careBare metal stentsMultivessel diseaseRepeat revascularizationCoronary interventionArtery diseaseMedical managementStent eraBalloon angioplastyNonrandomized studyLabel useTreatment modalitiesInvasive strategyClinical trials
2007
Impact of multivessel disease on reperfusion success and clinical outcomes in patients undergoing primary percutaneous coronary intervention for acute myocardial infarction
Sorajja P, Gersh BJ, Cox DA, McLaughlin MG, Zimetbaum P, Costantini C, Stuckey T, Tcheng JE, Mehran R, Lansky AJ, Grines CL, Stone GW. Impact of multivessel disease on reperfusion success and clinical outcomes in patients undergoing primary percutaneous coronary intervention for acute myocardial infarction. European Heart Journal 2007, 28: 1709-1716. PMID: 17556348, DOI: 10.1093/eurheartj/ehm184.Peer-Reviewed Original ResearchConceptsPrimary PCIPrimary percutaneous coronary interventionMajor adverse cardiac eventsAcute myocardial infarctionCoronary artery diseaseTriple vessel diseasePercutaneous coronary interventionMultivessel diseaseST-segment recoveryReperfusion successCoronary interventionClinical outcomesMyocardial blushMyocardial infarctionPost-procedural TIMI 3 flowExtent of CADExtensive coronary artery diseaseMultivessel coronary artery diseaseAdverse cardiac eventsTIMI 3 flowInfarct-related arterySingle-vessel diseaseCADILLAC trialPost-PCIInfarct vessel
2000
Current perspectives on interventional treatment strategies in diabetic patients with coronary artery disease
Kornowski R, Lansky A. Current perspectives on interventional treatment strategies in diabetic patients with coronary artery disease. Catheterization And Cardiovascular Interventions 2000, 50: 245-254. PMID: 10842400, DOI: 10.1002/(sici)1522-726x(200006)50:2<245::aid-ccd22>3.0.co;2-p.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseCoronary interventionBypass surgeryArtery diseaseDiabetes mellitusDiabetic patientsClinical outcomesCoronary artery bypass surgeryDiffuse coronary artery diseaseCatheter-based coronary interventionsArtery bypass surgeryCoronary bypass surgeryInterventional treatment strategiesPercutaneous coronary interventionUse of antiplateletAtherosclerosis lesion progressionTarget vessel sizeAdjunctive pharmacologyMore restenosisMultivessel diseaseAtherosclerosis burdenCoronary atherosclerosisCoronary proceduresCoronary sitesAdjunctive pharmacotherapyImportance of lesion length on new device angioplasty of native coronary arteries
Saucedo J, Kennard E, Popma J, Talley D, Lansky A, Leon M, Baim D. Importance of lesion length on new device angioplasty of native coronary arteries. Catheterization And Cardiovascular Interventions 2000, 50: 19-25. PMID: 10816274, DOI: 10.1002/(sici)1522-726x(200005)50:1<19::aid-ccd4>3.0.co;2-h.Peer-Reviewed Original ResearchConceptsTarget lesion revascularizationNew device angioplastyMore target lesion revascularizationLesion revascularizationLong lesionsLesion lengthRight coronary artery diseaseSmaller minimal lumen diameterLong lesion groupMore multivessel diseaseNative coronary arteriesCoronary artery diseaseCoronary Intervention RegistryEarly clinical eventsMinimal lumen diameterLonger lesion lengthMultivessel diseaseAngiographic outcomesIntervention RegistryArtery diseaseClinical outcomesHospital eventsTotal occlusionClinical eventsCoronary arteryRelation of coronary artery size to one-year clinical events after new device angioplasty of native coronary arteries (a New Approach to Coronary Intervention [NACI] Registry report)
Saucedo J, Popma J, Kennard E, Talley J, Lansky A, Leon M, Baim D, Investigators F. Relation of coronary artery size to one-year clinical events after new device angioplasty of native coronary arteries (a New Approach to Coronary Intervention [NACI] Registry report). The American Journal Of Cardiology 2000, 85: 166-171. PMID: 10955371, DOI: 10.1016/s0002-9149(99)00649-9.Peer-Reviewed Original ResearchConceptsReference vessel diameterNew device angioplastyNative coronary arteriesMinimal lumen diameterClinical eventsAngiographic outcomesCoronary arteryFinal minimal lumen diameterFinal percent diameter stenosisMajor adverse clinical eventsOne-year clinical eventsSmaller reference vessel diameterBaseline lesion characteristicsRisk of TLRCombined end pointAdverse clinical eventsCoronary artery diseaseCoronary Intervention RegistryEarly clinical eventsIncidence of deathSmall vesselsCoronary artery sizePercent diameter stenosisLesion revascularizationMultivessel disease