Clinical, immunophenotypic, and genomic findings of acute myeloid leukemia with RAM immunophenotype: Comparison with other CD56‐positive acute leukemias
Hamdan H, Liu Y, Wang S, Bledsoe J, Chisholm K, Siddon A, Ohgami R, George T, Kurzer J, Hasserjian R, Arber D, Bagg A, Foucar K, Margolskee E, Laczko D, Chen W, Fuda F, Aggarwal N, Weinberg O. Clinical, immunophenotypic, and genomic findings of acute myeloid leukemia with RAM immunophenotype: Comparison with other CD56‐positive acute leukemias. EJHaem 2024 DOI: 10.1002/jha2.1052.Peer-Reviewed Original ResearchAcute myeloid leukemiaAcute undifferentiated leukemiaExpression of CD56Children's Oncology GroupAcute leukemiaRAM immunophenotypeBlast percentageHLA-DRMyeloid leukemiaT-ALLBone marrowBright expressionFrequency of abnormal karyotypesWeak to absent expressionCharacteristics of acute myeloid leukemiaAcute myeloid leukemia groupAcute myeloid leukemia casesBCL6 co-repressorBM blast percentageWhite blood cell countAcute leukemia casesClinical differential diagnosisControl groupClinical outcome analysisNext-generation sequencing profilingClinical Characteristics and Outcomes of Mixed Phenotype Acute Leukemia (MPAL): A Large Multi-Center Retrospective Study
Cohen-Nowak A, Coltoff A, Patel A, Atallah E, El Kettani M, Wang J, Symes E, Venkataraman G, Siddon A, Giever E, Shallis R, Altman J, Bell-Burdett K, Badar T, Aqil B, Abaza Y. Clinical Characteristics and Outcomes of Mixed Phenotype Acute Leukemia (MPAL): A Large Multi-Center Retrospective Study. Blood 2024, 144: 2801-2801. DOI: 10.1182/blood-2024-199377.Peer-Reviewed Original ResearchALL-directed therapySubtypes of acute leukemiaOverall survivalIntensive chemotherapyAcute lymphoblastic leukemiaAcute myeloid leukemiaAllo-SCTOS ratesAcute leukemiaFLT3-ITDBridge to allogeneic stem cell transplantationBlast populationCNS diseaseMedian duration of responseAllogeneic stem cell transplantationMulti-center retrospective studyResistant to traditional therapiesAML-directed therapyDiagnosis of MPALMedian overall survivalIncomplete count recoveryInduce durable remissionsDuration of responseStem cell transplantationAllo-SCT recipients