Adam Krysztofiak, PhD
Associate Research Scientist in Therapeutic RadiologyDownloadHi-Res Photo
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Contact Info
Therapeutic Radiology
PO Box 208040
New Haven, CT 06520
United States
Publications Overview
- 15 Publications
- 384 Citations
- 11 Yale Co-Authors
Research Interests
Contact Info
Therapeutic Radiology
PO Box 208040
New Haven, CT 06520
United States
Publications Overview
- 15 Publications
- 384 Citations
- 11 Yale Co-Authors
Research Interests
Contact Info
Therapeutic Radiology
PO Box 208040
New Haven, CT 06520
United States
Publications Overview
- 15 Publications
- 384 Citations
- 11 Yale Co-Authors
Research Interests
About
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Titles
Associate Research Scientist in Therapeutic Radiology
Appointments
Therapeutic Radiology
Associate Research ScientistPrimary
Other Departments & Organizations
- Radiobiology
- Therapeutic Radiology
Education & Training
- Postdoctoral Associate
- Yale School of Medicine
- PhD
- University of Duisburg-Essen, Cancer and Radiation Biology (2019)
- MSc
- Poznan University of Medical Sciences, Pharmacy (2015)
Research
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Overview
Medical Research Interests
Biochemistry; Cell Biology; DNA Breaks; DNA Damage; DNA Repair; Molecular Biology; Proton Therapy; Radiation Oncology; Radiation, Ionizing; Radiobiology; Radiotherapy
Public Health Interests
Cancer; Metabolism; Pharmaceuticals and Medical Devices
ORCID
0000-0001-7813-7806
Research at a Glance
Research Interests
Research topics Adam Krysztofiak is interested in exploring.
Yale Co-Authors
Frequent collaborators of Adam Krysztofiak's published research.
Publications Timeline
A big-picture view of Adam Krysztofiak's research output by year.
DNA Damage
DNA Repair
Faye Rogers, PhD
Daniel Andrés Colón Ríos
Peter M. Glazer, MD, PhD
Yanfeng Liu
Jonathan Dow
Anthony Minnah
15Publications
384Citations
Publications
Featured Publications
Direct targeting of amplified gene loci for proapoptotic anticancer therapy
Kaushik Tiwari M, Colon-Rios DA, Tumu HCR, Liu Y, Quijano E, Krysztofiak A, Chan C, Song E, Braddock DT, Suh HW, Saltzman WM, Rogers FA. Direct targeting of amplified gene loci for proapoptotic anticancer therapy. Nature Biotechnology 2021, 40: 325-334. PMID: 34711990, PMCID: PMC8930417, DOI: 10.1038/s41587-021-01057-5.Peer-Reviewed Original ResearchCitationsAltmetricMetabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdown
Krysztofiak A, Szymonowicz K, Hlouschek J, Xiang K, Waterkamp C, Larafa S, Goetting I, Vega-Rubin-de-Celis S, Theiss C, Matschke V, Hoffmann D, Jendrossek V, Matschke J. Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdown. IScience 2021, 24: 103366. PMID: 34825138, PMCID: PMC8603201, DOI: 10.1016/j.isci.2021.103366.Peer-Reviewed Original ResearchCitationsAltmetricVulnerability of IDH1-Mutant Cancers to Histone Deacetylase Inhibition via Orthogonal Suppression of DNA Repair
Dow J, Krysztofiak A, Liu Y, Colon-Rios DA, Rogers FA, Glazer PM. Vulnerability of IDH1-Mutant Cancers to Histone Deacetylase Inhibition via Orthogonal Suppression of DNA Repair. Molecular Cancer Research 2021, 19: 2057-2067. PMID: 34535560, PMCID: PMC8642278, DOI: 10.1158/1541-7786.mcr-21-0456.Peer-Reviewed Original ResearchCitationsAltmetricProton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining
Szymonowicz K, Krysztofiak A, van der Linden J, Kern A, Deycmar S, Oeck S, Squire A, Koska B, Hlouschek J, Vüllings M, Neander C, Siveke J, Matschke J, Pruschy M, Timmermann B, Jendrossek V. Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining. Cells 2020, 9: 889. PMID: 32260562, PMCID: PMC7226794, DOI: 10.3390/cells9040889.Peer-Reviewed Original ResearchCitationsAltmetricHigh-throughput Evaluation of Protein Migration and Localization after Laser Micro-Irradiation
Oeck S, Malewicz NM, Krysztofiak A, Turchick A, Jendrossek V, Glazer PM. High-throughput Evaluation of Protein Migration and Localization after Laser Micro-Irradiation. Scientific Reports 2019, 9: 3148. PMID: 30816253, PMCID: PMC6395640, DOI: 10.1038/s41598-019-39760-8.Peer-Reviewed Original ResearchCitationsAltmetric
2025
PARP inhibitor resistance in IDH1-mutant cancers due to loss of end protection factors, 53BP1 and REV7
Colón-Ríos D, Dow J, Krysztofiak A, Liu Y, Rogers F, Glazer P. PARP inhibitor resistance in IDH1-mutant cancers due to loss of end protection factors, 53BP1 and REV7. NAR Cancer 2025, 7: zcaf047. PMID: 41357766, PMCID: PMC12675010, DOI: 10.1093/narcan/zcaf047.Peer-Reviewed Original ResearchThis study investigates how IDH1-mutant cancers develop resistance to PARP inhibitors through loss of end protection factors, 53BP1 and REV7, and shows that the drug cediranib can overcome this resistance, highlighting potential therapeutic strategies for improving cancer treatment outcomes.Cell-penetrating antibody enhances nuclear delivery of triplex-forming oligonucleotides targeting HER2-positive cancers
Minnah A, Tubéns N, Krysztofiak A, Liu Y, Glazer P, Rogers F. Cell-penetrating antibody enhances nuclear delivery of triplex-forming oligonucleotides targeting HER2-positive cancers. Molecular Therapy - Nucleic Acids 2025, 36: 102720. PMID: 41127334, PMCID: PMC12538099, DOI: 10.1016/j.omtn.2025.102720.Peer-Reviewed Original ResearchAltmetric
2024
Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition
Rackear M, Quijano E, Ianniello Z, Colón-Ríos D, Krysztofiak A, Abdullah R, Liu Y, Rogers F, Ludwig D, Dwivedi R, Bleichert F, Glazer P. Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition. Oncotarget 2024, 15: 699-713. PMID: 39352803, PMCID: PMC11444335, DOI: 10.18632/oncotarget.28651.Peer-Reviewed Original ResearchCitationsAltmetric
2022
The Pathogenic R3052W BRCA2 Variant Disrupts Homology-Directed Repair by Failing to Localize to the Nucleus
Jimenez-Sainz J, Krysztofiak A, Garbarino J, Rogers F, Jensen RB. The Pathogenic R3052W BRCA2 Variant Disrupts Homology-Directed Repair by Failing to Localize to the Nucleus. Frontiers In Genetics 2022, 13: 884210. PMID: 35711920, PMCID: PMC9197106, DOI: 10.3389/fgene.2022.884210.Peer-Reviewed Original ResearchCitationsAltmetric
2018
Relating Linear Energy Transfer to the Formation and Resolution of DNA Repair Foci After Irradiation with Equal Doses of X-ray Photons, Plateau, or Bragg-Peak Protons
Oeck S, Szymonowicz K, Wiel G, Krysztofiak A, Lambert J, Koska B, Iliakis G, Timmermann B, Jendrossek V. Relating Linear Energy Transfer to the Formation and Resolution of DNA Repair Foci After Irradiation with Equal Doses of X-ray Photons, Plateau, or Bragg-Peak Protons. International Journal Of Molecular Sciences 2018, 19: 3779. PMID: 30486506, PMCID: PMC6320817, DOI: 10.3390/ijms19123779.Peer-Reviewed Original ResearchCitationsAltmetric
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Therapeutic Radiology
PO Box 208040
New Haven, CT 06520
United States
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Hunter Building
15 York Street, Fl 2, Rm 210
New Haven, CT 06510
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203.785.7585