Mismatch Repair Genes May Be Key to Immunotherapy Response
A new study by Yale School of Medicine researchers has identified a possible explanation for why some cancers don’t respond to immunotherapy. In an analysis of a Phase II trial investigating the immunotherapy drug pembrolizumab in 24 patients with endometrial cancer, the team found faulty DNA repair in tumors was a key factor in determining patient outcomes. The study was published in Cancer Discovery.Source: Inside Precision Medicine
COVID-19 Virus Increases Risk for Other Infections by Disrupting Normal Mix of Gut Bacteria
Infection with the pandemic virus, SARS-CoV-2, can reduce the number of bacterial species in a patient’s gut, with the lesser diversity creating space for dangerous microbes to thrive, a new study finds.Source: NYU Langone Health
Will Long COVID Research Provide Answers for Poorly Understood Diseases Like ME/CFS?
ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) is a highly disabling, severe condition that has been largely overlooked and even questioned as an illness by physicians and biomedical researchers for decades. But now, scientists including Yale's Akiko Iwasaki and Harlan Krumholz are finding parallels between post-infection long COVID and ME/CFS.
‘Prime and Spike’ Nasal Vaccine Strategy Helps Combat COVID
The new “prime” and “spike” approach may help prevent breakthrough infections of vaccinated individuals by bolstering immune response within the mucosal lining of the respiratory tract, which are the first cells attacked by COVID-19.Source: YaleNews
Why Immunotherapy Works Well For Some Cancer Patients, But Not Others
Immunotherapy, a biotherapy that boosts the ability of the immune system to recognize and attack mutant tumor cells, has transformed the treatment landscape for patients battling cancer, which emerges from the progressive accumulation of DNA mutations. However, many patients do not respond to immunotherapy. For instance, among highly-mutated colorectal and endometrial cancers, research has shown that only half will show a response to immunotherapy.Source: Yale News
Ad Hoc Treatment Team Develops COVID Guidelines
In March 2020, Maricar Malinis, MD, FACP, FIDSA, FAST, and a group of colleagues were called to an emergency meeting. COVID-19 was on the horizon, and no one knew what to expect. The anxiety was palpable. The date itself was inauspicious: Friday the 13th.
Amy Justice awarded 2022 William S. Middleton award, the VA Biomedical Laboratory Research & Development Service’s highest honor for outstanding achievement in biomedical research
First, and on behalf of VHA and the Biomedical Laboratory Research & Development Service (BLR&D) in the Office of Research and Development, Dr. Amy Justice was recently named as a recipient of the 2022 William S. Middleton Award.
What We Learned About COVID-19 and Cold and Flu Season
Day-to-day life changed a lot when COVID-19 hit. To curb the spread of the virus, health experts urged us to social distance, wear a mask, and wash our hands all the time. Then a surprising thing happened. “All the normal respiratory infections we usually get -- from cold and flu viruses -- didn’t happen, which was very dramatic,” says Ellen Foxman, MD, PhD. She’s an immunobiologist at Yale Medicine and an assistant professor of laboratory medicine and immunobiology at Yale School of Medicine.Source: WebMD
Summer Flu, RSV in July, 'Super Colds'?
Richard Martinello, MD, a professor of medicine and pediatric infectious diseases at Yale University, doesn't expect to see a child hospitalized with respiratory syncytial virus (RSV) in the middle of summer. The illness, which can strike infants and older adults especially hard, is known as a "winter virus."Source: WebMD
Key Things To Know About the Monkeypox Vaccine and Prevention
Infectious disease experts in Connecticut are tracking a growing number monkeypox cases in the region and urging people to be on the lookout for signs and symptoms. It is caused by an infection of the monkeypox virus, which is a cousin of smallpox, resulting in a rash that looks like pimples or blisters. Thankfully, many people recover on their own.Source: YNHH