2021
Grappling with the tick microbiome
Narasimhan S, Swei A, Abouneameh S, Pal U, Pedra JHF, Fikrig E. Grappling with the tick microbiome. Trends In Parasitology 2021, 37: 722-733. PMID: 33962878, PMCID: PMC8282638, DOI: 10.1016/j.pt.2021.04.004.Peer-Reviewed Original ResearchConceptsTick microbiomeRelated tick speciesMultiple human pathogensHost preferenceSequencing technologiesTick biologyHuman pathogensMicrobiomeMechanistic insightsTick speciesLife cycleIxodes pacificusIxodes scapularisIxodid ticksCausative agentNorth AmericaBorrelia burgdorferiPredominant vectorBiological variablesHabitatsPacificusBiologySpeciesPathogens
2000
SALP16, a gene induced in Ixodes scapularis salivary glands during tick feeding.
Das S, Marcantonio N, Deponte K, Telford SR, Anderson JF, Kantor FS, Fikrig E. SALP16, a gene induced in Ixodes scapularis salivary glands during tick feeding. American Journal Of Tropical Medicine And Hygiene 2000, 62: 99-105. PMID: 10761732, DOI: 10.4269/ajtmh.2000.62.99.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsBase SequenceBlotting, WesternEnzyme-Linked Immunosorbent AssayFeeding BehaviorFemaleGene Expression RegulationGene LibraryGuinea PigsIxodesMiceMice, Inbred C3HMolecular Sequence DataPolymerase Chain ReactionRandom Amplified Polymorphic DNA TechniqueRecombinant ProteinsRNASalivary GlandsSalivary Proteins and PeptidesSequence Analysis, DNATick Infestations
1995
Selection of variant Borrelia burgdorferi isolates from mice immunized with outer surface protein A or B
Fikrig E, Tao H, Barthold SW, Flavell RA. Selection of variant Borrelia burgdorferi isolates from mice immunized with outer surface protein A or B. Infection And Immunity 1995, 63: 1658-1662. PMID: 7729870, PMCID: PMC173206, DOI: 10.1128/iai.63.5.1658-1662.1995.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, BacterialAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferi GroupCloning, MolecularFemaleGenes, BacterialGenetic VariationImmunoblottingLipoproteinsLyme DiseaseMiceMice, Inbred C3HRecombinant ProteinsSelection, GeneticSequence Analysis, DNAVaccinationConceptsSurface protein AOuter surface protein AProtective immunityProtective antibodiesIncomplete efficacyMiceMonoclonal antibodiesProtein ABorrelia burgdorferiB. burgdorferiAntigenic diversityOspBOspAVivo selective pressureImmunityAntibodiesB. burgdorferi isolatesBurgdorferiChallenge inoculationPoint mutationsMolecular basisVaccineInfection