Using human statistical genetics and genomics, and experimental biology to understand hematopoietic function in complex traits and diseases. Our primary disease focus is type 1 diabetes and its associated clinical phenotypes, including cardiovascular disease and neurofunction.
Human Genetics, Novel Technologies and CV imaging
Affiliated Faculty
We study tissue homeostasis through the lens of systems biology. Our work lies at the intersection of machine learning, single-cell and spatial technologies, and computational modeling.
Dr. Jennifer Kwan is a physician-scientist in cardiovascular medicine at Yale, where her translational research lab focuses on mechanisms of cardiotoxicity from cancer therapies and the role of clonal hematopoiesis/somatic variants in heart failure and cardio-oncology. She integrates large datasets leveraging AI, radiomics, and multi-omics approaches to predict cardiovascular outcomes and uncover novel therapeutic targets.
My lab investigates the molecular genetics and epigenetic mechanisms underlying cardiovascular disease, with a focus on metabolic syndrome, atherosclerosis, and aortic aneurysms.
Our research focuses on the development and clinical translation of novel molecular imaging approaches for tissue remodeling, fibrosis, and inflammation, as well as studying related molecular mechanisms in vascular and aortic valve biology.
Sinusas lab is directed at development, validation, and application of non-invasive cardiovascular imaging approaches for the assessment of cardiovascular pathophysiology, including the targeted molecular assessment of myocardial ischemic injury, post-infarction atrial and ventricular remodeling, peripheral artery disease, and cardiopulmonary disease. This research involves ex vivo and in vivo imaging in small and large animal models of cardiovascular disease with translation to humans.