Featured Publications
An allelic series of miR-17∼92–mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron
Han Y, Vidigal J, Mu P, Yao E, Singh I, González A, Concepcion C, Bonetti C, Ogrodowski P, Carver B, Selleri L, Betel D, Leslie C, Ventura A. An allelic series of miR-17∼92–mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron. Nature Genetics 2015, 47: 766-775. PMID: 26029871, PMCID: PMC4485521, DOI: 10.1038/ng.3321.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisB-LymphocytesCarcinogenesisCells, CulturedEyelidsGene FrequencyGenes, LethalGenome-Wide Association StudyIntellectual DisabilityLimb Deformities, CongenitalMaleMice, 129 StrainMice, Inbred C57BLMice, TransgenicMicrocephalyMicroRNAsMultigene FamilyMutationTracheoesophageal Fistula
2009
Genetic dissection of the miR-17∼92 cluster of microRNAs in Myc-induced B-cell lymphomas
Mu P, Han Y, Betel D, Yao E, Squatrito M, Ogrodowski P, de Stanchina E, D'Andrea A, Sander C, Ventura A. Genetic dissection of the miR-17∼92 cluster of microRNAs in Myc-induced B-cell lymphomas. Genes & Development 2009, 23: 2806-2811. PMID: 20008931, PMCID: PMC2800095, DOI: 10.1101/gad.1872909.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Line, TumorGene DeletionGenes, mycLymphoma, B-CellMiceMice, Inbred C57BLMice, NudeMicroRNAsConceptsMiR-17MiR-17~92 clusterMiR-19Computational target predictionMiR-19aTranscriptional target of c-MycMiR-19bTarget of c-MycMiR-17~92Cluster of microRNAsMyc-driven B-cell lymphomasConditional knockout alleleMouse model of B-cell lymphomaGene expression profilesGenetic dissectionIndividual miRNAsMiRNAsProsurvival activityTranscriptional targetsTarget predictionModel of B-cell lymphomaC-mycSuppressed apoptosisMicroRNAsExpression profiles