Featured Publications
An allelic series of miR-17∼92–mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron
Han Y, Vidigal J, Mu P, Yao E, Singh I, González A, Concepcion C, Bonetti C, Ogrodowski P, Carver B, Selleri L, Betel D, Leslie C, Ventura A. An allelic series of miR-17∼92–mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron. Nature Genetics 2015, 47: 766-775. PMID: 26029871, PMCID: PMC4485521, DOI: 10.1038/ng.3321.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisB-LymphocytesCarcinogenesisCells, CulturedEyelidsGene FrequencyGenes, LethalGenome-Wide Association StudyIntellectual DisabilityLimb Deformities, CongenitalMaleMice, 129 StrainMice, Inbred C57BLMice, TransgenicMicrocephalyMicroRNAsMultigene FamilyMutationTracheoesophageal Fistula
2022
The driver role of JAK‐STAT signalling in cancer stemness capabilities leading to new therapeutic strategies for therapy‐ and castration‐resistant prostate cancer
Lo U, Chen Y, Cen J, Deng S, Luo J, Zhau H, Ho L, Lai C, Mu P, Chung L, Hsieh J. The driver role of JAK‐STAT signalling in cancer stemness capabilities leading to new therapeutic strategies for therapy‐ and castration‐resistant prostate cancer. Clinical And Translational Medicine 2022, 12: e978. PMID: 35908276, PMCID: PMC9339240, DOI: 10.1002/ctm2.978.Peer-Reviewed Original ResearchConceptsCastration-resistant prostate cancerProstate cancerCancer stem cellsActivation of JAKJAK-STAT signalingGene set enrichment analysisJAK-STAT1 pathwaySTAT1 inhibitorAcquisition of stemness propertiesProstate cancer cell linesProstate cancer stemnessAssociated with cancer stem cellsIn vivo anti-tumor activityMetastatic prostate cancerTumor-initiating capabilityJAK-STATProstasphere assayDownstream effectorsIngenuity PathwayGenetic manipulationCSC genesBioinformatics analysisEnrichment analysisJAK-STAT1Signaling pathway
2012
Intact p53-Dependent Responses in miR-34–Deficient Mice
Concepcion C, Han Y, Mu P, Bonetti C, Yao E, D'Andrea A, Vidigal J, Maughan W, Ogrodowski P, Ventura A. Intact p53-Dependent Responses in miR-34–Deficient Mice. PLOS Genetics 2012, 8: e1002797. PMID: 22844244, PMCID: PMC3406012, DOI: 10.1371/journal.pgen.1002797.Peer-Reviewed Original ResearchConceptsMiR-34 familyMiR-34 expressionP53 pathwayP53-induced cell cycle arrestP53-independent functionsP53-dependent responseCell cycle arrestMiR-34Potential tumor suppressorExpression of membersP53-deficient miceP53-independentFamily of miRNAsP53 functionCycle arrestTumor suppressorMicroRNA familyCellular proliferation in vitroHuman cancersProliferation in vitroP53Brains of miceMicroRNAsNormal developmentMice
2010
Widespread regulatory activity of vertebrate microRNA* species
Yang J, Phillips M, Betel D, Mu P, Ventura A, Siepel A, Chen K, Lai E. Widespread regulatory activity of vertebrate microRNA* species. RNA 2010, 17: 312-326. PMID: 21177881, PMCID: PMC3022280, DOI: 10.1261/rna.2537911.Peer-Reviewed Original ResearchConceptsAnalysis of microarray dataVertebrate regulatory networksStudy of miRNA functionMiRNA:miRNARelevant to oncogenesisFraction of miRNAsTranscriptome-wide evidenceRegulatory networksMicroarray dataVertebrate evolutionSilencing complexMiRNA functionMiR-19RNA duplexesExpression constructsBioinformatics analysisMature miRNAsStrand speciesVertebratesSpeciesObligate intermediateSensor assayMutagenesis testsRepressionSeed sites
2009
Genetic dissection of the miR-17∼92 cluster of microRNAs in Myc-induced B-cell lymphomas
Mu P, Han Y, Betel D, Yao E, Squatrito M, Ogrodowski P, de Stanchina E, D'Andrea A, Sander C, Ventura A. Genetic dissection of the miR-17∼92 cluster of microRNAs in Myc-induced B-cell lymphomas. Genes & Development 2009, 23: 2806-2811. PMID: 20008931, PMCID: PMC2800095, DOI: 10.1101/gad.1872909.Peer-Reviewed Original ResearchConceptsMiR-17MiR-17~92 clusterMiR-19Computational target predictionMiR-19aTranscriptional target of c-MycMiR-19bTarget of c-MycMiR-17~92Cluster of microRNAsMyc-driven B-cell lymphomasConditional knockout alleleMouse model of B-cell lymphomaGene expression profilesGenetic dissectionIndividual miRNAsMiRNAsProsurvival activityTranscriptional targetsTarget predictionModel of B-cell lymphomaC-mycSuppressed apoptosisMicroRNAsExpression profiles