Targeted imaging of urothelium carcinoma in human bladders by an ICG pHLIP peptide ex vivo
Golijanin J, Amin A, Moshnikova A, Brito JM, Tran TY, Adochite RC, Andreev GO, Crawford T, Engelman DM, Andreev OA, Reshetnyak YK, Golijanin D. Targeted imaging of urothelium carcinoma in human bladders by an ICG pHLIP peptide ex vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 11829-11834. PMID: 27688767, PMCID: PMC5081621, DOI: 10.1073/pnas.1610472113.Peer-Reviewed Original ResearchConceptsBladder cancerEx vivoHigh-grade urothelial carcinomaPrevious transurethral resectionStandard pathological analysisNew treatment alternativesBladder preservationNonmuscle invasiveRadical surgeryTransurethral resectionMuscle invasiveBladder lesionsUrothelial carcinomaCystectomy specimensPathological assessmentExpensive cancerEarly diagnosisPathological analysisMalignant lesionsUrothelium carcinomaHuman bladderLow extracellular pHTreatment alternativesNecrotic tissueChances of survival