2020
The actin polymerization factor Diaphanous and the actin severing protein Flightless I collaborate to regulate sarcomere size
Deng S, Silimon R, Balakrishnan M, Bothe I, Juros D, Soffar D, Baylies M. The actin polymerization factor Diaphanous and the actin severing protein Flightless I collaborate to regulate sarcomere size. Developmental Biology 2020, 469: 12-25. PMID: 32980309, PMCID: PMC8279456, DOI: 10.1016/j.ydbio.2020.09.014.Peer-Reviewed Original ResearchConceptsActin thin filamentsFlightless IRegulate thin filament lengthContractile unit of muscleControl actin dynamicsActin polymerization factorsThin filamentsDrosophila flight muscleMyosin thick filamentsThin filament lengthSarcomere sizeActin regulatorsActin dynamicsFlight musclesThick filamentsActinMuscle developmentFilament lengthContractile unitsPolymerization factorsFunction of muscle fibersFilamentsSarcomereRegulationFormin
2015
The Formin Diaphanous Regulates Myoblast Fusion through Actin Polymerization and Arp2/3 Regulation
Deng S, Bothe I, Baylies M. The Formin Diaphanous Regulates Myoblast Fusion through Actin Polymerization and Arp2/3 Regulation. PLOS Genetics 2015, 11: e1005381. PMID: 26295716, PMCID: PMC4546610, DOI: 10.1371/journal.pgen.1005381.Peer-Reviewed Original ResearchConceptsF-actin fociF-actinActin polymerizationCell-cell fusionPodosome formationMyoblast fusionFusion siteElongation of actin filamentsRegulation of actin polymerizationLoss-of-function conditionsActin turnover rateBranched actin regulatorsDrosophila myoblast fusionBranched actin polymerizationPodosome-like structuresF-actin polymerizationF-actin distributionFormation of multinucleated muscle cellsArp2/3 regulatorsBranched actinActin regulatorsActin structuresDynamic filopodiaActin filamentsMutant alleles