The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizing FAK
Amin E, Liu Y, Deng S, Tan K, Chudgar N, Mayo M, Sanchez-Vega F, Adusumilli P, Schultz N, Jones D. The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizing FAK. Science Signaling 2017, 10 PMID: 28928239, PMCID: PMC5771642, DOI: 10.1126/scisignal.aah3941.Peer-Reviewed Original ResearchConceptsFocal adhesion kinaseRNA editing enzyme ADARPresence of ADARsAnalysis of gene expression patternsGenome-wide studiesLung adenocarcinoma cellsRNA-binding proteinsCell migration pathwaysGene expression patternsStabilized transcriptsIntron sitesADARProtein abundanceBinding proteinIncreased abundanceExpression patternsMolecular analysisStage I LUAD patientsPharmacological inhibitionProteinMesenchymal propertiesPotential therapeutic applicationsProtein levelsTranscriptionGenes