2015
The Formin Diaphanous Regulates Myoblast Fusion through Actin Polymerization and Arp2/3 Regulation
Deng S, Bothe I, Baylies M. The Formin Diaphanous Regulates Myoblast Fusion through Actin Polymerization and Arp2/3 Regulation. PLOS Genetics 2015, 11: e1005381. PMID: 26295716, PMCID: PMC4546610, DOI: 10.1371/journal.pgen.1005381.Peer-Reviewed Original ResearchConceptsF-actin fociF-actinActin polymerizationCell-cell fusionPodosome formationMyoblast fusionFusion siteElongation of actin filamentsRegulation of actin polymerizationLoss-of-function conditionsActin turnover rateBranched actin regulatorsDrosophila myoblast fusionBranched actin polymerizationPodosome-like structuresF-actin polymerizationF-actin distributionFormation of multinucleated muscle cellsArp2/3 regulatorsBranched actinActin regulatorsActin structuresDynamic filopodiaActin filamentsMutant alleles
2014
PI(4,5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site
Bothe I, Deng S, Baylies M. PI(4,5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site. Development 2014, 141: 2289-2301. PMID: 24821989, PMCID: PMC4034421, DOI: 10.1242/dev.100743.Peer-Reviewed Original ResearchMeSH KeywordsActin-Related Protein 2-3 ComplexActinsAnimalsCell CommunicationCell MembraneCytoskeletonDrosophila melanogasterGene Expression Regulation, DevelopmentalGenotypeMuscle Fibers, SkeletalMutationMyoblastsPhosphatidylinositol 4,5-DiphosphatePhospholipidsRac GTP-Binding ProteinsSignal TransductionConceptsF-actinRegulation of F-actin dynamicsActivator of actin polymerizationFusion siteF-actin fociMyoblast fusionF-actin dynamicsRegulation of actinCell-cell fusionActin regulatorsActin fociActin remodelingActin polymerizationPhosphoinositide PI(4,5)P2Regulates localizationCytoskeleton signalingOpposing membranesPI(4,5)P2ActinImpaired fusionArp2/3Receptor engagementCytoskeletonRegulationEnrichment