Intact p53-Dependent Responses in miR-34–Deficient Mice
Concepcion C, Han Y, Mu P, Bonetti C, Yao E, D'Andrea A, Vidigal J, Maughan W, Ogrodowski P, Ventura A. Intact p53-Dependent Responses in miR-34–Deficient Mice. PLOS Genetics 2012, 8: e1002797. PMID: 22844244, PMCID: PMC3406012, DOI: 10.1371/journal.pgen.1002797.Peer-Reviewed Original ResearchConceptsMiR-34 familyMiR-34 expressionP53 pathwayP53-induced cell cycle arrestP53-independent functionsP53-dependent responseCell cycle arrestMiR-34Potential tumor suppressorExpression of membersP53-deficient miceP53-independentFamily of miRNAsP53 functionCycle arrestTumor suppressorMicroRNA familyCellular proliferation in vitroHuman cancersProliferation in vitroP53Brains of miceMicroRNAsNormal developmentMice