Overcoming oncogene addiction in breast and prostate cancers: a comparative mechanistic overview.
Blatt E, Kopplin N, Kumar S, Mu P, Conzen S, Raj G. Overcoming oncogene addiction in breast and prostate cancers: a comparative mechanistic overview. Endocrine Related Cancer 2021, 28: r31-r46. PMID: 33263560, PMCID: PMC8218927, DOI: 10.1530/erc-20-0272.Peer-Reviewed Original ResearchConceptsProstate cancerHormone-dependent cancersBreast cancerTherapy resistanceAndrogen receptorMechanisms of endocrine therapy resistanceTherapeutic strategiesTherapy-resistant prostate cancerEndocrine therapy resistanceAdvanced prostate cancerTherapy-resistant tumorsNuclear receptorsMechanisms of resistancePotential therapeutic strategyEndocrine therapyMetastatic patientsAntiestrogen resistanceOncogene addictionClinical benefitTumor typesEstrogen receptorFrequent mechanismCancerReceptorsAugmented activity