2023
Personalizing approaches to the management of metastatic hormone sensitive prostate cancer: role of advanced imaging, genetics and therapeutics
Lokeshwar S, Choksi A, Haltstuch D, Rahman S, Press B, Syed J, Hurwitz M, Kim I, Leapman M. Personalizing approaches to the management of metastatic hormone sensitive prostate cancer: role of advanced imaging, genetics and therapeutics. World Journal Of Urology 2023, 41: 2007-2019. PMID: 37160450, DOI: 10.1007/s00345-023-04409-9.Peer-Reviewed Original ResearchConceptsMetastatic hormone-sensitive prostate cancerAndrogen deprivation therapyHormone-sensitive prostate cancerSensitive prostate cancerPositron emission tomographyConventional computerized tomographyDocetaxel chemotherapyClinical trialsProstate cancerCombination of ADTBackbone of treatmentCytoreductive radical prostatectomySequencing of therapyFirst-line treatmentEvaluation of patientsClinical practice guidelinesOngoing clinical trialsAndrogen receptor antagonistPubMed Medline databaseDeprivation therapyInitial managementOverall survivalStaging evaluationBone scanRandomized trials
2018
National trends in the management of patients with positive surgical margins at the time of radical prostatectomy.
Ghabili K, Nguyen K, Hsiang W, Syed J, Suarez-Sarmiento A, Shuch B, Park H, Yu J, Leapman M. National trends in the management of patients with positive surgical margins at the time of radical prostatectomy. Journal Of Clinical Oncology 2018, 36: 111-111. DOI: 10.1200/jco.2018.36.6_suppl.111.Peer-Reviewed Original ResearchAdjuvant radiation therapyAndrogen deprivation therapyPositive surgical marginsNational Cancer DatabaseAdjuvant therapyRadical prostatectomyRadiation therapyProstate cancerPathologic featuresSurgical marginsAddition of ADTAdjuvant androgen deprivation therapyStudy periodPre-treatment PSAPrimary definitive treatmentMajority of patientsManagement of patientsGleason grade groupCourse of managementOptimal management approachNon-academic facilitiesLogistic regression modelsBinary logistic regression modelAnalysis menDeprivation therapy
2016
Relationship of phosphodiesterase type 5 inhibitor to biochemical recurrence after definitive therapy for prostate cancer.
Leapman M, Cowan J, Nguyen H, Porten S, Cooperberg M, Carroll P. Relationship of phosphodiesterase type 5 inhibitor to biochemical recurrence after definitive therapy for prostate cancer. Journal Of Clinical Oncology 2016, 34: 119-119. DOI: 10.1200/jco.2016.34.2_suppl.119.Peer-Reviewed Original ResearchPhosphodiesterase type 5 inhibitorsBiochemical recurrenceType 5 inhibitorsProstate cancerUse of PDE5iMedian age 61 yearsMedian age 69 yearsProstate Strategic Urologic Research EndeavorRisk of BCRCox proportional hazards modelAndrogen deprivation therapyAge 61 yearsAge 69 yearsKaplan-Meier methodSexual function scoresCohort of menProportional hazards modelDeprivation therapyPrescription complianceDefinitive therapyTime-dependent useDefinitive treatmentDisease recurrenceClinical evidenceBaseline useClinical Risk Prediction Tools for Prostate Cancer: TNM to CAPRA—Should Risk Be Redefined?
Leapman M, Cooperberg M. Clinical Risk Prediction Tools for Prostate Cancer: TNM to CAPRA—Should Risk Be Redefined? 2016, 33-52. DOI: 10.1007/978-3-319-21485-6_3.Peer-Reviewed Original ResearchPrimary androgen deprivation therapyClinical risk prediction toolsUCSF-CAPRA scoreAndrogen deprivation therapyRisk stratification toolPretreatment clinical variablesRisk prediction toolsProstate cancer biologyProstate Cancer Risk PredictionCancer risk predictionAdvanced diseaseDeprivation therapyReliable risk estimationClinical characteristicsStratification toolClinical stageClinical variablesGleason scoreOutcomes warrantsRisk groupingPostsurgical settingProstate cancerInternational cohortClinical prognosticationNovel biomarkers
2015
MP87-04 TIMING OF SALVAGE ANDROGEN DEPRIVATION THERAPY FOLLOWING PROSTATE RADIOTHERAPY DOES NOT ADVERSELY AFFECT ALL-CAUSE OR PROSTATE CANCER SPECIFIC SURVIVAL
Sagalovich D, Leapman M, Sfakianos J, Hall S, Stock R, Stone N. MP87-04 TIMING OF SALVAGE ANDROGEN DEPRIVATION THERAPY FOLLOWING PROSTATE RADIOTHERAPY DOES NOT ADVERSELY AFFECT ALL-CAUSE OR PROSTATE CANCER SPECIFIC SURVIVAL. Journal Of Urology 2015, 193: e1085. DOI: 10.1016/j.juro.2015.02.1949.Peer-Reviewed Original Research