2013
BMP-6 in Renal Cell Carcinoma Promotes Tumor Proliferation through IL-10–Dependent M2 Polarization of Tumor-Associated Macrophages
Lee J, Lee G, Woo S, Ha Y, Kwon S, Kim W, Kim I. BMP-6 in Renal Cell Carcinoma Promotes Tumor Proliferation through IL-10–Dependent M2 Polarization of Tumor-Associated Macrophages. Cancer Research 2013, 73: 3604-3614. PMID: 23633487, DOI: 10.1158/0008-5472.can-12-4563.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic Protein 6Carcinoma, Renal CellCell LineCell Line, TumorCell ProliferationClodronic AcidDoxycyclineHumansImmunoblottingInterleukin-10Kaplan-Meier EstimateKidney NeoplasmsMacrophagesMiceMice, Inbred BALB CMice, KnockoutMicroscopy, FluorescenceReverse Transcriptase Polymerase Chain ReactionRNA InterferenceSmad5 ProteinSTAT3 Transcription FactorTumor Burden
2011
Bone morphogenetic protein 6-induced interleukin-1β expression in macrophages requires PU.1/Smad1 interaction
Lee G, Jung Y, Lee J, Kim W, Kim I. Bone morphogenetic protein 6-induced interleukin-1β expression in macrophages requires PU.1/Smad1 interaction. Molecular Immunology 2011, 48: 1540-1547. PMID: 21571370, DOI: 10.1016/j.molimm.2011.04.019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic Protein 6Bone Morphogenetic Protein Receptors, Type IBone Morphogenetic Protein Receptors, Type IICells, CulturedExtracellular Signal-Regulated MAP KinasesFluorescent Antibody TechniqueImmunoblottingImmunoprecipitationInterleukin-1betaJNK Mitogen-Activated Protein KinasesMacrophagesMiceNitric Oxide Synthase Type IIProto-Oncogene ProteinsReverse Transcriptase Polymerase Chain ReactionSignal TransductionSmad1 ProteinTrans-Activators
2003
Decreased expression of bone morphogenetic protein (BMP) receptor type II correlates with insensitivity to BMP-6 in human renal cell carcinoma cells.
Kim I, Lee D, Lee D, Kim B, Kim H, Leach F, Linehan W, Morton R, Kim S. Decreased expression of bone morphogenetic protein (BMP) receptor type II correlates with insensitivity to BMP-6 in human renal cell carcinoma cells. Clinical Cancer Research 2003, 9: 6046-51. PMID: 14676131.Peer-Reviewed Original ResearchBlotting, NorthernBone Morphogenetic Protein 6Bone Morphogenetic Protein Receptors, Type IIBone Morphogenetic ProteinsCarcinoma, Renal CellDown-RegulationHumansImmunoblottingImmunoenzyme TechniquesKidney NeoplasmsProtein Serine-Threonine KinasesReceptors, Cell SurfaceReverse Transcriptase Polymerase Chain ReactionTransforming Growth Factor betaTumor Cells, Cultured