The association of humoral antigen spread (AgS) with cytotoxic T lymphocyte (CTL) activity after sipuleucel-T (sip-T) treatment in two phase II clinical studies: STAMP and STRIDE.
Petrylak D, Antonarakis E, Kandadi H, Fong L, Lance R, Vu T, Sheikh N, Shore N, Drake C. The association of humoral antigen spread (AgS) with cytotoxic T lymphocyte (CTL) activity after sipuleucel-T (sip-T) treatment in two phase II clinical studies: STAMP and STRIDE. Journal Of Clinical Oncology 2020, 38: 112-112. DOI: 10.1200/jco.2020.38.6_suppl.112.Peer-Reviewed Original ResearchCTL activityAntibody responseAntigen spreadMetastatic castration-resistant prostate cancerCytotoxic T lymphocyte activityCastration-resistant prostate cancerPhase II clinical studyAg responseImproved overall survivalSipuleucel-T treatmentSpecific CTL activityTumor immunity cycleT lymphocyte activityII clinical studySecondary antibody responseRank testSpearman rank testCD107a expressionSpecific CD8Immunity cycleOverall survivalLymphocyte activityAntigen responseMultiple time pointsProstate cancer