Randomized phase II study of docetaxel with or without ramucirumab (IMC-1121B) or icrucumab (IMC-18F1) in patients with urothelial transitional cell carcinoma (TCC) following progression on first-line platinum-based therapy.
Petrylak D, Chi K, Vogelzang N, Sonpavde G, Rutstein M, Schwartz J, Fox F, Wang W, Abad L, Cosaert J, Grebennik D. Randomized phase II study of docetaxel with or without ramucirumab (IMC-1121B) or icrucumab (IMC-18F1) in patients with urothelial transitional cell carcinoma (TCC) following progression on first-line platinum-based therapy. Journal Of Clinical Oncology 2012, 30: tps4675-tps4675. DOI: 10.1200/jco.2012.30.15_suppl.tps4675.Peer-Reviewed Original ResearchProgression-free survivalTransitional cell carcinomaHuman IgG1 monoclonal antibodyVEGF receptor 2Platinum-based therapyDay 1VEGFR-1IgG1 monoclonal antibodyMonoclonal antibodiesFirst-line platinum-based therapyMedian progression-free survivalPrior platinum-based therapyRandomized phase II studyVascular endothelial growth factor (VEGF) pathwayEndothelial growth factor pathwayPrior antiangiogenic therapyUrothelial transitional cell carcinomaOpen-label treatmentPhase II studySecondary outcome measuresDuration of responseLevels of PlGFPlacental growth factorOne-sided alphaSoluble VEGFR-2