TRITON3: An international, randomized, open-label, phase III study of the PARP inhibitor rucaparib vs. physician’s choice of therapy for patients with metastatic castration-resistant prostate cancer (mCRPC) associated with homologous recombination deficiency (HRD).
Ryan C, Abida W, Bryce A, Balar A, Dumbadze I, Given R, Morris D, Petrylak D, Redfern C, Scher H, Watkins S, Simmons A, Passler L, Golsorkhi T, Chowdhury S. TRITON3: An international, randomized, open-label, phase III study of the PARP inhibitor rucaparib vs. physician’s choice of therapy for patients with metastatic castration-resistant prostate cancer (mCRPC) associated with homologous recombination deficiency (HRD). Journal Of Clinical Oncology 2018, 36: tps389-tps389. DOI: 10.1200/jco.2018.36.6_suppl.tps389.Peer-Reviewed Original ResearchMetastatic castration-resistant prostate cancerHomologous recombination deficiencyIndependent radiology reviewHomologous recombination (HR) DNA repair genesPhysician's choiceRadiology reviewDeleterious germlineProstate cancerRadiographic progression-free survivalCastration-resistant prostate cancerDNA repair genesObjective response rateProgression-free survivalPretreatment blood samplesAdvanced prostate cancerDuration of responsePatient-reported outcomesRepair genesMCRPC settingSecondary endpointsPrimary endpointRadiographic progressionOverall survivalComparator treatmentSomatic BRCA1