2004
Responses to a Saline Load in Gonadotropin-Releasing Hormone Antagonist-Pretreated Premenopausal Women Receiving Progesterone or Estradiol-Progesterone Therapy
Stachenfeld NS, Keefe DL, Taylor HS. Responses to a Saline Load in Gonadotropin-Releasing Hormone Antagonist-Pretreated Premenopausal Women Receiving Progesterone or Estradiol-Progesterone Therapy. The Journal Of Clinical Endocrinology & Metabolism 2004, 90: 386-394. PMID: 15486051, DOI: 10.1210/jc.2004-0941.Peer-Reviewed Original ResearchConceptsSodium regulationOvarian hyperstimulation syndromeEffects of estradiolMin of restImportant clinical implicationsHyperstimulation syndromeSodium excretionGnRH antagonistRenal diseaseSodium loadIsotonic salineClinical implicationsSyndromeReproductive syndromeSubjectsPreeclampsiaGnRHGroupEstradiolProgesteroneAntagonistExcretionDiseaseAdministrationSaline
2003
Oestrogen effects on urine concentrating response in young women
Stachenfeld NS, Taylor HS, Leone CA, Keefe DL. Oestrogen effects on urine concentrating response in young women. The Journal Of Physiology 2003, 552: 869-880. PMID: 12923212, PMCID: PMC2343447, DOI: 10.1113/jphysiol.2003.046920.Peer-Reviewed Original ResearchConceptsAVP infusionRenal sensitivityHormone treatmentDistal tubular sodium reabsorptionRenal free water clearanceRenal fluid retentionTubular sodium reabsorptionFree water clearancePlasma AVP concentrationArginine vasopressin releaseRate of clearancePhysiological rangeOE2 treatmentSodium excretionGnRHa administrationSodium reabsorptionEstrogen effectsEstrogen treatmentFluid retentionLeuprolide acetateWater clearanceRenal waterAVP concentrationVasopressin releaseUrine osmolality
2002
Estrogen effects on osmotic regulation of AVP and fluid balance
Stachenfeld NS, Keefe DL. Estrogen effects on osmotic regulation of AVP and fluid balance. AJP Endocrinology And Metabolism 2002, 283: e711-e721. PMID: 12217888, DOI: 10.1152/ajpendo.00192.2002.Peer-Reviewed Original ResearchConceptsHormone treatmentEstrogen effectsPlasma renin activityFree water clearanceEnd of recoveryIntrarenal effectsRenal sensitivityRenin activitySodium excretionFractional excretionAVP increaseSodium retentionFluid retentionLeuprolide acetateWater clearanceEndogenous estrogensAldosterone stimulationFluid balanceGnRHaNaCl infusionPg/EstrogenAVPProgesteroneExcretion
1998
Estrogen influences osmotic secretion of AVP and body water balance in postmenopausal women
Stachenfeld N, Dipietro L, Palter S, Nadel E. Estrogen influences osmotic secretion of AVP and body water balance in postmenopausal women. American Journal Of Physiology 1998, 274: r187-r195. PMID: 9458917, DOI: 10.1152/ajpregu.1998.274.1.r187.Peer-Reviewed Original ResearchConceptsMin of drinkingPg/Body water balanceHypertonic salineFractional sodium excretionPlasma aldosterone concentrationRenal sodium reabsorptionFree water clearancePlasma estradiol concentrationsHypertonic saline infusionHigh E2 statesWater ad libitumMosmol/kgH2OAldosterone concentrationPostmenopausal womenSodium excretionPlacebo administrationUrine outputAVP secretionSodium reabsorptionFluid retentionE2 treatmentEstradiol concentrationsWater clearanceSaline infusion
1997
Mechanism of attenuated thirst in aging: role of central volume receptors
Stachenfeld N, DiPietro L, Nadel E, Mack G. Mechanism of attenuated thirst in aging: role of central volume receptors. American Journal Of Physiology 1997, 272: r148-r157. PMID: 9039003, DOI: 10.1152/ajpregu.1997.272.1.r148.Peer-Reviewed Original ResearchConceptsCentral blood volume expansionBlood volume expansionYoung subjectsOlder subjectsPlasma volumePlasma atrial natriuretic peptide concentrationAtrial natriuretic peptide concentrationsThirst ratingsOlder peopleFractional sodium excretionPlasma renin activityArterial blood pressureNatriuretic peptide concentrationsCentral volume expansionMin of headWater perfusion suitAd libitum water intakeAldosterone concentrationRenin activitySodium excretionArterial baroreceptorsArterial pressureBlood pressureRenal responseVolume receptors
1996
Fluid balance and renal response following dehydrating exercise in well-trained men and women
Stachenfeld N, Gleim G, Zabetakis P, Nicholas J. Fluid balance and renal response following dehydrating exercise in well-trained men and women. European Journal Of Applied Physiology 1996, 72: 468-477. PMID: 8925818, DOI: 10.1007/bf00242277.Peer-Reviewed Original ResearchConceptsPlasma renin activityEnd of exerciseSodium handlingMin postexerciseEarly recoveryFluid balanceLow plasma renin activityRenal free water clearancePlasma volumeFractional sodium excretionPlasma osmolalityFree water clearanceOverall fluid balanceMin of recoveryFluid-regulating hormonesRenin activitySodium excretionSerum aldosteroneNorepinephrine concentrationsRenal responseWater clearanceRenal waterAnaerobic thresholdWater reabsorptionWomen