2023
Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome
Stone T, Yanes Cardozo L, Oluwatade T, Leone C, Burgos M, Okifo F, Pal L, Reckelhoff J, Stachenfeld N. Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome. AJP Heart And Circulatory Physiology 2023, 325: h232-h243. PMID: 37327000, PMCID: PMC10393337, DOI: 10.1152/ajpheart.00164.2023.Peer-Reviewed Original ResearchConceptsSympathetic nervous system activityBlood pressure dysregulationPolycystic ovary syndromeBody mass indexBaroreflex gainOvary syndromeBlood pressureObese insulin-resistant womenPolycystic ovary syndrome phenotypesRenin-angiotensin system activationSerum angiotensin-converting enzymeGonadotropin-releasing hormone antagonistLower sympathetic nervous system activityLower body negative pressureHeightened cardiovascular riskInsulin-resistant womenSystolic blood pressureBody negative pressureNervous system activityAngiotensin-converting enzymeIR womenCardiovascular riskSerum aldosteroneBaroreflex controlDiastolic BPTestosterone effects on autonomic function in women with androgen excess polycystic ovary syndrome
Stone T, Cardozo L, Oluwatade T, Leone C, Okifo F, Reckelhoff J, Pal L, Stachenfeld N. Testosterone effects on autonomic function in women with androgen excess polycystic ovary syndrome. Physiology 2023, 38: 5729543. DOI: 10.1152/physiol.2023.38.s1.5729543.Peer-Reviewed Original ResearchLower body negative pressureBlood pressureHormone interventionSympathetic baroreflexAutonomic functionSimilar systolic blood pressureGonadotropin-releasing hormone antagonistInsulin-resistant womenDiastolic blood pressurePolycystic ovary syndromeSystolic blood pressureCardiovascular autonomic controlBody negative pressureMSNA activitySerum angiotensinOvarian syndromeOvary syndromeResistant womenBaroreflex sensitivityHormone suppressionSerum aldosteroneAutonomic perturbationsT elevationHormone antagonistElevated androgens
2021
Androgen Effects on Baroreflex Sensitivity in Women with AE‐PCOS
Stone T, Chiles M, Leone C, Pal L, Stachenfeld N. Androgen Effects on Baroreflex Sensitivity in Women with AE‐PCOS. The FASEB Journal 2021, 35 DOI: 10.1096/fasebj.2021.35.s1.04149.Peer-Reviewed Original ResearchMuscle sympathetic nerve activityLower body negative pressureSympathetic baroreflex sensitivityPolycystic ovary syndromeBaroreflex sensitivityBR controlDiastolic BPHormone suppressionImpaired blood pressure regulationGonadotropin-releasing hormone antagonistOral glucose tolerance testDays of GnRHSympathetic nerve activityInsulin-resistant womenMean arterial pressureVascular resistance changesReproductive-age womenGlucose tolerance testBody negative pressureBlood pressure regulationSuppression of E2Bursts/100 heartbeatsCardiovascular comorbiditiesPCOS phenotypeResistant women
2014
Dichotomous estradiol and genistein effects on cutaneous endothelium‐dependent vasodilation in women with and without insulin resistance (678.6)
Wenner M, Taylor H, Stachenfeld N. Dichotomous estradiol and genistein effects on cutaneous endothelium‐dependent vasodilation in women with and without insulin resistance (678.6). The FASEB Journal 2014, 28 DOI: 10.1096/fasebj.28.1_supplement.678.6.Peer-Reviewed Original ResearchEndothelial-dependent dilationInsulin-resistant womenCutaneous vascular conductanceL-NMMAHealthy womenGenistein effectsEndothelium-dependent vasodilationLaser Doppler flowmetryResistant womenVascular conductanceE2 effectsInsulin resistanceMicrodialysis infusionDependent dilationDoppler flowmetryGEN effectsWomenE2National InstituteGrant funding sourcesC heatingCVCmaxVasodilationCardioprotectionFlowmetry