Abstract 3092: Smooth Muscle Cell Tgf-β Receptor Knockout Improves Arteriovenous Fistula Maturation Via Attenuation Of Autophagy
Zhang W, Bai H, Gonzalez L, Li Z, Ohashi Y, Thaxton C, aoyagi Y, Yatsula B, Kano M, Xie Y, Cai Y, Chang S, Dardik A. Abstract 3092: Smooth Muscle Cell Tgf-β Receptor Knockout Improves Arteriovenous Fistula Maturation Via Attenuation Of Autophagy. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44 DOI: 10.1161/atvb.44.suppl_1.3092.Peer-Reviewed Original ResearchChronic kidney diseaseSmooth muscle cellsEnd-stage renal diseaseArteriovenous fistulaHuman arteriovenous fistulaeControl miceC57BL/6J miceCKD showRate of primary failureBasilic vein transpositionTGF-bModel of arteriovenous fistulaTGF-b1 expressionArteriovenous fistula failureArteriovenous fistula maturationWild type miceControl C57BL/6J miceIncreased markers of autophagyTGF-b signalingVein transpositionAortocaval fistulaAVF maturationReceptor knockoutMT/mG miceSham nephrectomyDisturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia
Bai H, Varsanik M, Thaxton C, Ohashi Y, Gonzalez L, Zhang W, Aoyagi Y, Kano M, Yatsula B, Li Z, Pocivavsek L, Dardik A. Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia. AJP Heart And Circulatory Physiology 2024, 326: h1446-h1461. PMID: 38578237, DOI: 10.1152/ajpheart.00054.2024.Peer-Reviewed Original ResearchConceptsEndothelial cell lossOutflow veinChronic kidney diseaseJuxta-anastomotic areaMouse AVF modelNeointimal hyperplasiaThrombus formationAcute thrombus formationCell lossHuman AVF maturationGene OntologyAVF maturationAVF patencyEarly thrombus formationArteriovenous fistulaC57BL/6 miceClinical failureWistar ratsEndothelial lossKidney diseaseImmune responseEndothelial cellsHyperplasiaMiceAVF