2024
Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling
Ohashi Y, Protack C, Aoyagi Y, Gonzalez L, Thaxton C, Zhang W, Kano M, Bai H, Yatsula B, Alves R, Hoshina K, Schneider E, Long X, Perry R, Dardik A. Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling. Scientific Reports 2024, 14: 13287. PMID: 38858395, PMCID: PMC11164895, DOI: 10.1038/s41598-024-64075-8.Peer-Reviewed Original ResearchConceptsGene expression patternsArteriovenous fistula groupArteriovenous fistulaExpression patternsHeterogeneous gene expressionGene expression changesOutcomes of arteriovenous fistulaVenous remodelingArteriovenous fistula maturationPostoperative day 7Reduce patient morbidityRNA sequencingUpregulation of metabolismBioinformatics analysisGene expressionDownregulation of metabolismMetabolic pathwaysExpression changesGenesAVF maturationAVF remodelingFistula creationC57BL/6 miceClinical outcomesPatient morbidityDisturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia
Bai H, Varsanik M, Thaxton C, Ohashi Y, Gonzalez L, Zhang W, Aoyagi Y, Kano M, Yatsula B, Li Z, Pocivavsek L, Dardik A. Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia. AJP Heart And Circulatory Physiology 2024, 326: h1446-h1461. PMID: 38578237, DOI: 10.1152/ajpheart.00054.2024.Peer-Reviewed Original ResearchConceptsEndothelial cell lossOutflow veinChronic kidney diseaseJuxta-anastomotic areaMouse AVF modelNeointimal hyperplasiaThrombus formationAcute thrombus formationCell lossHuman AVF maturationGene OntologyAVF maturationAVF patencyEarly thrombus formationArteriovenous fistulaC57BL/6 miceClinical failureWistar ratsEndothelial lossKidney diseaseImmune responseEndothelial cellsHyperplasiaMiceAVF
2023
Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model
Satam K, Ohashi Y, Thaxton C, Gonzalez L, Setia O, Bai H, Aoyagi Y, Xie Y, Zhang W, Yatsula B, Martin K, Cai Y, Dardik A. Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model. AJP Heart And Circulatory Physiology 2023, 325: h77-h88. PMID: 37145957, PMCID: PMC10243550, DOI: 10.1152/ajpheart.00049.2023.Peer-Reviewed Original ResearchConceptsIntact female miceAVF maturationSex hormonesT cellsFemale miceArteriovenous fistulaMale miceMouse modelHigher IL-10Arteriovenous fistula creationImmune cell recruitmentSex-specific therapiesHormone receptor signalingSex differencesHuman AVF maturationAVF surgeryMale patientsClinical outcomesFemale patientsFistula maturationIL-10C57BL/6 miceInferior outcomesVenous adaptationFistula creation
2022
Sex differences in arterial identity correlate with neointimal hyperplasia after balloon injury
Gao M, Gao X, Taniguchi R, Brahmandam A, Matsubara Y, Liu J, Liu H, Zhang W, Dardik A. Sex differences in arterial identity correlate with neointimal hyperplasia after balloon injury. Molecular Biology Reports 2022, 49: 8301-8315. PMID: 35715609, PMCID: PMC9463237, DOI: 10.1007/s11033-022-07644-2.Peer-Reviewed Original ResearchConceptsBalloon injuryFemale ratsArterial remodelingNeointimal proliferationCarotid arteryNeointimal thicknessSex differencesLeft common carotid arteryAtherosclerotic arterial diseaseSmooth muscle cell proliferationRight carotid arteryCarotid balloon injuryMale Sprague-DawleyCommon carotid arteryBaseline sex differencesMuscle cell proliferationErythropoietin-producing hepatocellular (Eph) receptorsBackgroundEndovascular treatmentArterial diseaseArterial injuryClinical outcomesSex hormonesUninjured controlsArterial identitySprague-Dawley
2019
Contrast-Induced Kidney Nephropathy in Thoracic Endovascular Aortic Repair: A 2-Year Retrospective Study in 470 Patients
Li X, Zhang W, Liu J, Gonzalez L, Liu D, Zhang L, Dardik A, Shu C. Contrast-Induced Kidney Nephropathy in Thoracic Endovascular Aortic Repair: A 2-Year Retrospective Study in 470 Patients. Angiology 2019, 71: 242-248. PMID: 31829038, DOI: 10.1177/0003319719893578.Peer-Reviewed Original ResearchConceptsThoracic endovascular aortic repairContrast-induced nephropathyEndovascular aortic repairContrast volumeRenal functionAortic dissectionAortic repairRenal arteryRisk factorsRenal artery involvementRenal failure rateKaplan-Meier curvesSerum urea nitrogenArtery involvementRenal comorbiditiesInjury groupSerum creatinineConsecutive patientsKidney functionRetrospective studyKidney nephropathyRenal pathologyUrea nitrogenSurvival rateLogistic regressionMidterm Outcomes of Endovascular Repair for Stanford Type B Aortic Dissection with Aberrant Right Subclavian Artery
Zhang W, Li X, Cai W, Li M, Qiu J, Shu C. Midterm Outcomes of Endovascular Repair for Stanford Type B Aortic Dissection with Aberrant Right Subclavian Artery. Journal Of Vascular And Interventional Radiology 2019, 30: 1378-1385. PMID: 31133449, DOI: 10.1016/j.jvir.2019.02.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAortic AneurysmAortic DissectionBlood Vessel ProsthesisBlood Vessel Prosthesis ImplantationCardiovascular AbnormalitiesEndovascular ProceduresFemaleHumansMaleMiddle AgedOperative TimePostoperative ComplicationsProsthesis DesignRetrospective StudiesRisk FactorsStentsSubclavian ArteryTime FactorsTreatment OutcomeConceptsAberrant right subclavian arteryType B aortic dissectionStanford type B aortic dissectionThoracic endovascular aortic repairRight subclavian arteryB aortic dissectionEndovascular repairKommerell's diverticulumMidterm outcomesChimney techniqueAortic dissectionSubclavian arteryImmediate type Ia endoleakRight upper extremity weaknessDouble chimney techniqueMean preoperative diameterPreoperative imaging examinationUpper extremity weaknessType Ia endoleakDominant vertebral arterySpinal cord ischemiaEndovascular aortic repairMean procedural timeCerebral blood flowTotal endovascular repair