2024
Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia
Bai H, Varsanik M, Thaxton C, Ohashi Y, Gonzalez L, Zhang W, Aoyagi Y, Kano M, Yatsula B, Li Z, Pocivavsek L, Dardik A. Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia. AJP Heart And Circulatory Physiology 2024, 326: h1446-h1461. PMID: 38578237, DOI: 10.1152/ajpheart.00054.2024.Peer-Reviewed Original ResearchConceptsEndothelial cell lossOutflow veinChronic kidney diseaseJuxta-anastomotic areaMouse AVF modelNeointimal hyperplasiaThrombus formationAcute thrombus formationCell lossHuman AVF maturationGene OntologyAVF maturationAVF patencyEarly thrombus formationArteriovenous fistulaC57BL/6 miceClinical failureWistar ratsEndothelial lossKidney diseaseImmune responseEndothelial cellsHyperplasiaMiceAVF
2018
Atorvastatin regulates pericardial patch healing via the microRNA140-ADAM10-ephrinB2 pathway.
Li X, Dardik A, Guo R, Zhang W, Xiang Y, Li S, Liu D, Shu C. Atorvastatin regulates pericardial patch healing via the microRNA140-ADAM10-ephrinB2 pathway. American Journal Of Translational Research 2018, 10: 4054-4064. PMID: 30662650, PMCID: PMC6325491.Peer-Reviewed Original ResearchPericardial patch angioplastyDose-dependent mannerPatch angioplastyPericardial patchMRNA expressionMiR-140 expressionADAM10 protein expressionDaily doseCardiovascular injuryVascular proceduresVascular surgeryEndothelium repairWistar ratsNeointimal formationNeointimal growthControl animalsEarly healingAtorvastatinCardiovascular systemStatin drugsWestern blotEphrinB2 expressionEphrinB2 mRNAProtein expressionAngioplasty